The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution
Open accessAbstract
Flu Drift Limited: Five antigenic sites in the virus surface hemagglutinin protein, which together comprise 131 amino acid positions, are thought to determine the full scope of antigenic drift of influenza A virus. Koel et al. (p. 976 ) show that major antigenic change can be caused by single amino acid substitutions. These single substitutions substantially skew the way the immune system “sees” the virus. All substitutions of importance are located next to the receptor-binding site in the hemagglutinin. Because there are few positions of importance for antigenic drift, there are strict biophysical limitations to the substitutions at these positions, which restricts the number of new antigenic drift variants at any point in time. Thus, the evolution of influenza virus may be more predictable than previously thought.
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Cites
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Cited by
Zost, S. J., Parkhouse, K., Gumina, M. E., Kim, K., Diaz Perez, S., Wilson, P. C., Treanor, J. J., Sant, A. J., Cobey, S., & Hensley, S. E. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1712377114 · Cited by 563
Skowronski, D. M., Janjua, N. Z., De Serres, G., Sabaiduc, S., Eshaghi, A., Dickinson, J. A., Fonseca, K., Winter, A.-L., Gubbay, J. B., Krajden, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092153 · Cited by 416
Newman, J., Thakur, N., Peacock, T. P., Bialy, D., Elrefaey, A. M. E., Bogaardt, C., Horton, D. L., Ho, S., Kankeyan, T., Carr, C., et al. (2022) · Nature Microbiology · doi:10.1038/s41564-022-01163-3 · Cited by 85
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Metadata
- Authors
- Koel, B. F., Burke, D. F., Bestebroer, T. M., van der Vliet, S., Zondag, G. C. M., Vervaet, G., Skepner, E., Lewis, N. S., Spronken, M. I. J., Russell, C. A., Eropkin, M. Y., Hurt, A. C., Barr, I. G., de Jong, J. C., Rimmelzwaan, G. F., Osterhaus, A. D. M. E., Fouchier, R. A. M., & Smith, D. J.
- Venue
- Science
- Published
- 2013-11-22
- Volume
- 342
- Issue
- 6161
- Pages
- 976-979
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2031843685
- Cited by
- 632
- References
- 26
- FWCI
- 30.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Koel, B. F., Burke, D. F., Bestebroer, T. M., van der Vliet, S., Zondag, G. C. M., Vervaet, G., Skepner, E., Lewis, N. S., Spronken, M. I. J., Russell, C. A., Eropkin, M. Y., Hurt, A. C., Barr, I. G., de Jong, J. C., Rimmelzwaan, G. F., Osterhaus, A. D. M. E., Fouchier, R. A. M., & Smith, D. J. (2013). Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution. Science. https://doi.org/10.1126/science.1244730
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
