Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
Krönke, Jan, Udeshi, Namrata D., Narla, Anupama, Grauman, Peter, Hurst, Slater N., McConkey, Marie, Svinkina, Tanya, Heckl, Dirk, Comer, Eamon, Li, Xiaoyu, Ciarlo, Christie, Hartman, Emily, Munshi, Nikhil, Schenone, Monica, Schreiber, Stuart L., Carr, Steven A., Ebert, Benjamin L.·2014·Science
Cited by (1,006)
Items 301–400 of 1,006
- Ikaros family zinc finger 1 regulates dendritic cell development and function in humansUrszula Cytlak, Anastasia Resteu, Delfien Bogaert, Hye Sun Kuehn, Thomas Altmann, Andrew Richard Gennery, Graham Hunter Jackson, Attila Kumánovics, Karl V. Voelkerding, Seraina Prader et al. · 2018 · Nature Communications
- Mapping the effects of drugs on the immune systemBrian A. Kidd, Aleksandra Wroblewska, Mary Regina Boland, Judith Agudo, Miriam Mérad, Nicholas P. Tatonetti, Brian D. Brown, Joel T. Dudley · 2015 · Nature Biotechnology
- N -Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer CellsEmmanuelle Thinon, Julia Morales‐Sanfrutos, David J. Mann, Edward W. Tate · 2016 · ACS Chemical Biology
- Gain-of-function IKZF1 variants in humans cause immune dysregulation associated with abnormal T/B cell late differentiationAkihiro Hoshino, David Boutboul, Yuan Zhang, Hye Sun Kuehn, Jérôme Hadjadj, Nihal Özdemir, Tiraje Tülin Celkan, Christoph Walz, Capucine Pïcard, Christelle Lenoir et al. · 2022 · Science Immunology
- UBE2G1 governs the destruction of cereblon neomorphic substratesLu, Gang, Weng, Stephanie, Matyskiela, Mary, Zheng, Xinde, Fang, Wei, Wood, Scott, Surka, Christine, Mizukoshi, Reina, Lu, Chin-Chun, Mendy, Derek et al. · 2018 · eLife
- PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 NetworkReichermeier, Kurt M., Straube, Ronny, Reitsma, Justin M., Sweredoski, Michael J., Rose, Christopher M., Moradian, Annie, den Besten, Willem, Hinkle, Trent, Verschueren, Erik, Petzold, Georg et al. · 2020 · Molecular Cell
- The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemiaHubo Li, Brenton G. Mar, Huadi Zhang, Rishi V. Puram, Francisca Vazquez, Barbara A. Weir, William C. Hahn, Benjamin L. Ebert, David S. Pellman · 2016 · Blood
- Recent advances in the molecular mechanism of thalidomide teratogenicityGao, Shaobing, Wang, Shichao, Fan, Ruihua, Hu, Jieying · 2020 · Biomedicine & Pharmacotherapy
- Multiple Myeloma Therapy: Emerging Trends and ChallengesDanai Dima, Dongxu Jiang, Divya Jyoti Singh, Metis Hasipek, Haikoo Shah, Fauzia Ullah, Jack Khouri, Jaroslaw Pawel Maciejewski, Babal Kant Jha · 2022 · Cancers
- Protein Degradation via CRL4CRBN Ubiquitin Ligase: Discovery and Structure–Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1Joshua D. Hansen, Kevin R. Condroski, Matthew Correa, George W. Muller, Hon‐Wah Man, Alexander L. Ruchelman, Weihong Zhang, Fan Vocanson, Tim Crea, Wei Liu et al. · 2017 · Journal of Medicinal Chemistry
- Design, synthesis and biological evaluation of [1,2,4]triazolo[1,5-a]pyrimidines as potent lysine specific demethylase 1 (LSD1/KDM1A) inhibitorsShuai Wang, Li-Jie Zhao, Yi‐Chao Zheng, Dandan Shen, Er-Fei Miao, Xue-Peng Qiao, Lijuan Zhao, Ying Min Liu, Ruilei Huang, Bin Yu et al. · 2016 · European Journal of Medicinal Chemistry
- Molecular mechanisms of cereblon-based drugsTomoko Asatsuma‐Okumura, Takumi Ito, Hiroshi Handa · 2019 · Pharmacology & Therapeutics
- A Chemical Biology View of Bioactive Small Molecules and a Binder‐Based Approach to Connect Biology to Precision MedicinesStuart L. Schreiber · 2018 · Israel Journal of Chemistry
- Plant ubiquitin ligases as signaling hubsNitzan Shabek, Ning Zheng · 2014 · Nature Structural & Molecular Biology
- Preclinical activity of CPI-0610, a novel small-molecule bromodomain and extra-terminal protein inhibitor in the therapy of multiple myelomaKa Tat Siu, Janani Ramachandran, Andrew Jenho Yee, Homare Eda, Loredana Santo, Cristina Panaroni, Jennifer A. Mertz, Robert J. Sims, Michael Robert Cooper, Noopur S Raje · 2016 · Leukemia
- Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tetherTorres, Sandra Elizabeth, Gallagher, Ciara M, Plate, Lars, Gupta, Meghna, Liem, Christina R, Guo, Xiaoyan, Tian, Ruilin, Stroud, Robert M, Kampmann, Martin, Weissman, Jonathan S et al. · 2019 · eLife
- IRF4 in multiple myeloma—Biology, disease and therapeutic targetAlessandro Agnarelli, Timothy J. T. Chevassut, Erika J. Mancini · 2018 · Leukemia Research
- A Metabolomics Approach to Pharmacotherapy PersonalizationElena E. Balashova, Dmitry L. Maslov, Petr G. Lokhov · 2018 · Journal of Personalized Medicine
- Ubiquitin ligases in cancer: Functions and clinical potentialsShanshan Duan, Michele Pagano · 2021 · Cell chemical biology
- CRISPR Screen Reveals BRD2/4 Molecular Glue-like Degrader via Recruitment of DCAF16Andrea G. Shergalis, Violeta L. Marin, David Y. Rhee, Sameera Senaweera, Rebecca L. McCloud, Judith A. Ronau, Charles W. Hutchins, Shaun M. McLoughlin, Kevin R. Woller, Scott E. Warder et al. · 2023 · ACS Chemical Biology
- Hypoxia-inducible KDM3A addiction in multiple myelomaSho Ikeda, Akihiro Kitadate, Fumito Abe, Naoto Takahashi, Hiroyuki Tagawa · 2018 · Blood Advances
- Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171Subramaniam, Agatheeswaran, Žemaitis, Kristijonas, Talkhoncheh, Mehrnaz Safaee, Yudovich, David, Bäckström, Alexandra, Debnath, Shubhranshu, Chen, Jun, Jain, Mayur Vilas, Galeev, Roman, Gaetani, Massimiliano et al. · 2020 · Blood
- Discovery of ARD-2051 as a Potent and Orally Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor for the Treatment of Advanced Prostate CancerXin Han, Lijie Zhao, Weiguo Xiang, Bukeyan Miao, Chong Qin, Mi Wang, Tianfeng Xu, Donna McEachern, Jianfeng Lü, Yu Wang et al. · 2023 · Journal of Medicinal Chemistry
- Clec16a, Nrdp1, and USP8 Form a Ubiquitin-Dependent Tripartite Complex That Regulates β-Cell MitophagyGemma L. Pearson, Biaoxin Chai, Tracy D. Vozheiko, Xueying Liu, Malathi Kandarpa, Robert C. Piper, Scott A. Soleimanpour · 2017 · Diabetes
- Hi-JAK-ing the ubiquitin system: The design and physicochemical optimisation of JAK PROTACsRishi R. Shah, Joanna M. Redmond, Andrei Mihut, Malini R. Menon, John P. Evans, John Anthony Murphy, Michelle A. Bartholomew, Diane M. Coe · 2020 · Bioorganic & Medicinal Chemistry
- Marrow-Infiltrating Regulatory T Cells Correlate with the Presence of Dysfunctional CD4+PD-1+ Cells and Inferior Survival in Patients with Newly Diagnosed Multiple MyelomaNouf Alrasheed, Lydia S.H. Lee, Ehsan Ghorani, Jake Y. Henry, Lucía Conde, Melody Chin, Daria Galas‐Filipowicz, Andrew J.S. Furness, Selina J Chavda, Huw Richards et al. · 2020 · Clinical Cancer Research
- The immunomodulatory drugs lenalidomide and pomalidomide enhance the potency of AMG 701 in multiple myeloma preclinical modelsShih‐Feng Cho, Liang Lin, Lijie Xing, Yuyin Li, Kenneth Wen, Tengteng Yu, Phillip A. Hsieh, Nikhil C. Munshi, Joachim Wahl, Katja Matthes et al. · 2020 · Blood Advances
- De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide DerivativesChristopher Heim, Dimanthi Pliatsika, Farnoush Mousavizadeh, Kerstin Bär, Birte Hernandez Alvarez, Athanassios Giannis, Marcus D. Hartmann · 2019 · Journal of Medicinal Chemistry
- A novel cereblon modulator for targeted protein degradationKim, Sung Ah, Go, Ara, Jo, Seung-Hyun, Park, Sun Jun, Jeon, Young Uk, Kim, Ji Eun, Lee, Heung Kyoung, Park, Chi Hoon, Lee, Chong-Ock, Park, Sung Goo et al. · 2019 · European Journal of Medicinal Chemistry
- A suite of mathematical solutions to describe ternary complex formation and their application to targeted protein degradation by heterobifunctional ligandsBomie Han · 2020 · Journal of Biological Chemistry
- Definition of a small core transcriptional circuit regulated by AML1-ETOKristy R. Stengel, Jacob D. Ellis, Clare Spielman, Monica L. Bomber, Scott W. Hiebert · 2020 · Molecular Cell
- Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistenceYulong Wei, Timothy C. Davenport, Jack A. Collora, Haocong Katherine Ma, Delia Pinto-Santini, Javier R. Lama, Ricardo Alfaro, Ann C. Duerr, Ya‐Chi Ho · 2023 · Immunity
- Inducing protein-protein interactions with molecular gluesYe Che, Adam M. Gilbert, Veerabahu Shanmugasundaram, Mark C. Noe · 2018 · Bioorganic & Medicinal Chemistry Letters
- Therapeutic Targeting of Signaling Pathways Related to Cancer StemnessAsunción Espinosa-Sánchez, Elisa Suárez-Martínez, Laura Sánchez-Díaz, Amancio Carnero · 2020 · Frontiers in Oncology
- RNA-binding protein 39: a promising therapeutic target for cancerCaipeng Xu, Xiaohua Chen, Xuetian Zhang, Dapeng Zhao, Zhihui Dou, Xiaodong Xie, Hongyan Li, Hongying Yang, Qiang Li, Hong Zhang et al. · 2021 · Cell Death Discovery
- Influence of Linker Attachment Points on the Stability and Neosubstrate Degradation of Cereblon LigandsAleša Bricelj, Yuen Lam Dora Ng, Dominic Ferber, Robert D. Kuchta, Sina Müller, Marius Monschke, Karl Gerhard Wagner, Jan Krönke, Izidor Sosič, Michael Gütschow et al. · 2021 · ACS Medicinal Chemistry Letters
- The Tao of myelomaLawrence Boise, Jonathan L. Kaufman, Nizar Jacques Bahlis, Sagar Lonial, Kelvin P. Lee · 2014 · Blood
- RNA Polymerase I Inhibition with CX‐5461 as a Novel Therapeutic Strategy to Target MYC in Multiple MyelomaHans Chulhee Lee, Hua Wang, Veerabhadran Baladandayuthapani, Heather Yan Lin, Jin He, Richard Julian Jones, Isere Kuiatse, Dongmin Gu, Zhiqiang Wang, Wencai Ma et al. · 2017 · British Journal of Haematology
- Chemical Ligand Space of CereblonIuliia Boichenko, Kerstin Bär, Silvia Deiss, Christopher Heim, Reinhard Albrecht, Andrei N. Lupas, Birte Hernandez Alvarez, Marcus D. Hartmann · 2018 · ACS Omega
- Hydrophobic tag-based protein degradation: Development, opportunity and challengeQindi He, Xiaofei Zhao, Donglin Wu, Siming Jia, Canlin Liu, Zitian Cheng, Fei Huang, Yadong Chen, Tao Lu, Shuai Lü · 2023 · European Journal of Medicinal Chemistry
- The next-generation KRAS inhibitors…What comes after sotorasib and adagrasib?Yuko Oya, Kazuyoshi Imaizumi, Tetsuya Mitsudomi · 2024 · Lung Cancer
- Monomeric Targeted Protein DegradersHanan, Emily J., Liang, Jun, Wang, Xiaojing, Blake, Robert A., Blaquiere, Nicole, Staben, Steven T. · 2020 · Journal of Medicinal Chemistry
- Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradationYamanaka, Satoshi, Furihata, Hirotake, Yanagihara, Yuta, Taya, Akihito, Nagasaka, Takato, Usui, Mai, Nagaoka, Koya, Shoya, Yuki, Nishino, Kohei, Yoshida, Shuhei et al. · 2023 · Nature Communications
- Opportunities and challenges of protein-based targeted protein degradationFangfang Shen, Laura M. K. Dassama · 2023 · Chemical Science
- Computer-Aided Drug Discovery for Undruggable TargetsQi Sun, Hanping Wang, Juan Xie, Liying Wang, Junxi Mu, Junren Li, Yuhao Ren, Luhua Lai · 2025 · Chemical Reviews
- The emerging role for Cullin 4 family of E3 ligases in tumorigenesisJi Cheng, Jianping Guo, Brian J. North, Kaixiong Tao, Pengbo Zhou, Wenyi Wei · 2018 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Relapsed/Refractory Multiple Myeloma in 2020/2021 and BeyondKlaus Podar, Xavier P Leleu · 2021 · Cancers
- Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myelomaYuen Lam Dora Ng, Evelyn Ramberger, Stephan Bohl, Anna Dolnik, Christian Steinebach, Theresia Conrad, Sina Müller, Oliver Popp, Miriam Kull, Mohamed Haji et al. · 2022 · Nature Communications
- Induced protein degradation for therapeutics: past, present, and futureHojong Yoon, Justine C. Rutter, Yen-Der Li, Benjamin L. Ebert · 2024 · Journal of Clinical Investigation
- Malignant causes of fever of unknown originVanessa Foggo, Jamie D. Cavenagh · 2015 · Clinical Medicine
- Linking predation risk, ungulate antipredator responses, and patterns of vegetation in the high AndesEmiliano Donadío, Steven W. Buskirk · 2016 · Journal of Mammalogy
- IKZF1/3 and CRL4CRBN E3 ubiquitin ligase mutations and resistance to immunomodulatory drugs in multiple myelomaBarrio, Santiago, Munawar, Umair, Zhu, Yuan Xiao, Giesen, Nicola, Shi, Chang-Xin, Viá, Matteo Da, Sanchez, Ricardo, Bruins, Laura, Demler, Theresa, Müller, Nicole et al. · 2020 · Haematologica
- Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruptionPhoebe K. Mondala, Ashni A. Vora, Tianyuan Zhou, Elisa Lazzari, Luisa Ladel, Xiaolin Luo, Youngsoo Kim, Caitlin L. Costello, A. Robert MacLeod, Catriona H. M. Jamieson et al. · 2021 · Cell stem cell
- The rise of degrader drugsMingxing Teng, Nathanael S. Gray · 2023 · Cell chemical biology
- Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunityKenji Ichiyama, Jia Long, Yusuke Kobayashi, Yuji Horita, Takeshi Kinoshita, Yamami Nakamura, Chizuko Kominami, Katia Georgopoulos, Shimon Sakaguchi · 2024 · Immunity
- The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude miceZubin Zhang, Jiefei Tong, Xiaowen Tang, Jiaxiang Juan, Biyin Cao, Rose Hurren, Guodong Chen, Paul P. Taylor, Xin Xu, Chang-Xin Shi et al. · 2016 · Blood
- The Ubiquitin System in Immune RegulationYoon Park, Hyung‐seung Jin, Daisuke Aki, Jeeho Lee, Yun‐Cai Liu · 2014 · Advances in immunology
- An Ex Vivo Platform for the Prediction of Clinical Response in Multiple MyelomaAriosto Silva, Maria Cláudia Silva, Praneeth Reddy Sudalagunta, Allison I. Graeter, Timothy Jacobson, Aunshka Collins, Tuan Nguyen, Jinming Song, Dung‐Tsa Chen, Lu Chen et al. · 2017 · Cancer Research
- FOXF1 Defines the Core-Regulatory Circuitry in Gastrointestinal Stromal TumorLeili Ran, Yuedan Chen, Jessica J. Sher, Elissa W.P. Wong, Devan A. Murphy, Jenny Q. Zhang, Dan Li, Kemal Denız, Inna Sirota, Zhen Cao et al. · 2017 · Cancer Discovery
- Bifunctional Small‐Molecule Ligands of K‐Ras Induce Its Association with Immunophilin ProteinsZhang, Ziyang, Shokat, Kevan M. · 2019 · Angewandte Chemie International Edition
- Cereblon loss and up-regulation of c-Myc are associated with lenalidomide resistance in multiple myeloma patientsFranssen, Laurens E., Nijhof, Inger S., Couto, Suzana, Levin, Mark-David, Bos, Gerard M.J., Broijl, Annemiek, Klein, Saskia K., Ren, Yan, Wang, Maria, Koene, Harry R. et al. · 2018 · Haematologica
- Immunotherapy in myeloma: how far have we come?Laurens E. Franssen, Tuna Mutis, Henk M. Lokhorst, Niels W.C.J. van de Donk · 2019 · Therapeutic Advances in Hematology
- Targeted protein posttranslational modifications by chemically induced proximity for cancer therapyYunhua Peng, Jing Liu, Hiroyuki Inuzuka, Wenyi Wei · 2023 · Journal of Biological Chemistry
- Targeted protein degradation in cancers: Orthodox PROTACs and beyondJin Li, Xinxin Chen, Aiping Lü, Chao Liang · 2023 · The Innovation
- Quantitative Lys-ϵ-Gly-Gly (diGly) Proteomics Coupled with Inducible RNAi Reveals Ubiquitin-mediated Proteolysis of DNA Damage-inducible Transcript 4 (DDIT4) by the E3 Ligase HUWE1Joel W. Thompson, Jane Nagel, Sjouke Hoving, Bertran Gerrits, Andreas Bauer, Jason R. Thomas, Marc W. Kirschner, Markus Schirle, Sarah J. Luchansky · 2014 · Journal of Biological Chemistry
- Proteolysis-Targeting Chimeras: Harnessing the Ubiquitin-Proteasome System to Induce Degradation of Specific Target ProteinsKevin G. Coleman, Craig M. Crews · 2017 · Annual Review of Cancer Biology
- A MedChem toolbox for cereblon-directed PROTACsChristian Steinebach, Izidor Sosič, Stefanie Lindner, Aleša Bricelj, Franziska Kohl, Yuen Lam Dora Ng, Marius Monschke, Karl Gerhard Wagner, Jan Krönke, Michael Gütschow · 2019 · MedChemComm
- Soluble SLAMF7 promotes the growth of myeloma cells via homophilic interaction with surface SLAMF7Jiro Kikuchi, Mitsuo Hori, Hidekatsu Iha, Noriko Toyama‐Sorimachi, Shotaro Hagiwara, Yoshiaki Kuroda, Daisuke Koyama, Tohru Izumi, Hiroshi Yasui, Atsushi Suzuki et al. · 2019 · Leukemia
- Development of MDM2 degraders based on ligands derived from Ugi reactions: Lessons and discoveriesWang, Bo, Liu, Jin, Tandon, Ira, Wu, Suzhen, Teng, Peng, Liao, Jianhua, Tang, Weiping · 2021 · European Journal of Medicinal Chemistry
- Rational combination treatment with histone deacetylase inhibitors and immunomodulatory drugs in multiple myelomaTeru Hideshima, Francesca Cottini, Hiroto Ohguchi, Jana Jakubı́ková, Güllü Görgün, Naoya Mimura, YT Tai, Nikhil C. Munshi, Paul Gerard Guy Richardson, Kenneth Carl Anderson · 2015 · Blood Cancer Journal
- Emerging drug development technologies targeting ubiquitination for cancer therapeuticsGianluca Veggiani, María Carla Rosales Gerpe, Sachdev S. Sidhu, Wei Zhang · 2019 · Pharmacology & Therapeutics
- Drug resistance in multiple myeloma: Soldiers and weapons in the bone marrow nicheSolimando, Antonio Giovanni, Malerba, Eleonora, Leone, Patrizia, Prete, Marcella, Terragna, Carolina, Cavo, Michele, Racanelli, Vito · 2022 · Frontiers in Oncology
- Peptidic degron for IMiD-induced degradation of heterologous proteinsVidyasagar Koduri, Samuel K. McBrayer, Ella Liberzon, Adam C. Wang, Kimberly J. Briggs, Hyejin Cho, William G. Kaelin · 2019 · Proceedings of the National Academy of Sciences
- Small molecule PROTACs: an emerging technology for targeted therapy in drug discoveryHaixiang Pei, Yangrui Peng, Qiuhua Zhao, Yihua Chen · 2019 · RSC Advances
- Protein Engineering in the Ubiquitin System: Tools for Discovery and BeyondBo Zhao, Yien Che Tsai, Bo Jin, Bufan Wang, Yiyang Wang, Han Zhou, Tomaya Carpenter, Allan M. Weissman, Jun Yin · 2020 · Pharmacological Reviews
- Ubiquitin-specific proximity labeling for the identification of E3 ligase substratesHai‐Tsang Huang, Ryan J. Lumpkin, Ryan W. Tsai, Shuyao Su, Xu Zhao, Yuan Xiong, James Chen, Nada Mageed, Katherine A. Donovan, Eric S. Fischer et al. · 2024 · Nature Chemical Biology
- The development of high-content screening (HCS) technology and its importance to drug discoveryIvan Fraietta, Fabio Gasparri · 2016 · Expert Opinion on Drug Discovery
- Cereblon: A Protein Crucial to the Multiple Functions of Immunomodulatory Drugs as well as Cell Metabolism and Disease GenerationQinglin Shi, Lijuan Chen · 2017 · Journal of Immunology Research
- Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogsAdam Samuel Sperling, Michael W. Burgess, Hasmik Keshishian, Jessica A. Gasser, Shruti Bhatt, Max Jan, Mikolaj Michal Slabicki, Rob S. Sellar, Emma C. Fink, Peter Grant Miller et al. · 2019 · Blood
- Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216Teng, Mingxing, Lu, Wenchao, Donovan, Katherine A., Sun, Jialin, Krupnick, Noah M., Nowak, Radosław P., Li, Yen-Der, Sperling, Adam S., Zhang, Tinghu, Ebert, Benjamin L. et al. · 2022 · Journal of Medicinal Chemistry
- High-Risk Multiple Myeloma: Integrated Clinical and Omics Approach Dissects the Neoplastic Clone and the Tumor MicroenvironmentAntonio Giovanni Solimando, Matteo Da Vià, Sebastiano Cicco, Patrizia Leone, Giuseppe Di Lernia, Donato Giannico, Vanessa Desantis, Maria Antonia Frassanito, Arcangelo Morizio, Julia Delgado Tascon et al. · 2019 · Journal of Clinical Medicine
- Discovery of a Napabucasin PROTAC as an Effective Degrader of the E3 Ligase ZFP91Maha Hanafi, Xinde Chen, Nouri Neamati · 2021 · Journal of Medicinal Chemistry
- Stopping the beating heart of cancer: KRAS reviewedLorenz Herdeis, Daniel Gerlach, Darryl B. McConnell, Dirk Kessler · 2021 · Current Opinion in Structural Biology
- Expression of cereblon protein assessed by immunohistochemicalstaining in myeloma cells is associated with superior response of thalidomide- and lenalidomide-based treatment, but not bortezomib-based treatment, in patients with multiple myelomaHuang, Shang-Yi, Lin, Chung-Wu, Lin, Hsiu-Hsia, Yao, Ming, Tang, Jih-Luh, Wu, Shang-Ju, Chen, Yao-Chang, Lu, Hsiao-Yun, Hou, Hsin-An, Chen, Chien-Yuan et al. · 2014 · Annals of Hematology
- Ubiquitin diGLY Proteomics as an Approach to Identify and Quantify the Ubiquitin-Modified ProteomeAmit Fulzele, Eric J. Bennett · 2018 · Methods in molecular biology
- Repurposing old drugs as new inhibitors of the ubiquitin-proteasome pathway for cancer treatmentHuanjie Yang, Xin Chen, Kai Li, Hassan Ali Cheaito, Qianqian Yang, Guojun Wu, Jinbao Liu, Q. Ping Dou · 2019 · Seminars in Cancer Biology
- Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biologyTakumi Ito, Yuki Yamaguchi, Hiroshi Handa · 2021 · Cell chemical biology
- Unveiling the hidden interactome of CRBN molecular gluesKheewoong Baek, Rebecca J. Metivier, Shourya S. Roy Burman, Jonathan W. Bushman, Hojong Yoon, Ryan J. Lumpkin, Julia K. Ryan, Dinah M. Abeja, Megha Lakshminarayan, Hong Yue et al. · 2025 · Nature Communications
- CAR T-Cell Therapy: The Role of Physical Barriers and Immunosuppression in LymphomaGunilla Enblad, Hannah Karlsson, Angelica Loskog · 2015 · Human Gene Therapy
- Immunomodulatory drugs activate NK cells via both Zap-70 and cereblon-dependent pathwaysTeru Hideshima, Daisuke Ogiya, Jiye Liu, Takeshi Harada, Keiji Kurata, Jooeun E. Bae, Walter W. Massefski, Kenneth Carl Anderson · 2020 · Leukemia
- The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride ChannelsChen, Yi-An, Peng, Yi-Jheng, Hu, Meng-Chun, Huang, Jing-Jia, Chien, Yun-Chia, Wu, June-Tai, Chen, Tsung-Yu, Tang, Chih-Yung · 2015 · Scientific Reports
- Lenalidomide in non-Hodgkin lymphoma: biological perspectives and therapeutic opportunitiesAthena Kritharis, Michael Coyle, Jaya Sharma, Andrew M. Evens · 2015 · Blood
- The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myelomaMichael Heider, Ruth Eichner, Jacob Stroh, Volker Morath, Anna Kuisl, Jana Zecha, Jannis Lawatscheck, Kheewoong Baek, Anne-Kathrin Garz, Martina Rudelius et al. · 2021 · Molecular Cell
- Ubiquitin proteasome system in immune regulation and therapeuticsSameer Ahmed Bhat, Zahra Vasi, Ritika Adhikari, Anish Gudur, Asceal Ali, Liping Jiang, Rachel Ferguson, David Liang, Shafi Kuchay · 2022 · Current Opinion in Pharmacology
- Discovery of Exceptionally Potent, Selective, and Efficacious PROTAC Degraders of CBP and p300 ProteinsJunius Eugene Thomas, Mi Wang, Wei Jiang, Meilin Wang, Lu Wang, Bo Wen, Duxin Sun, Shaomeng Wang · 2023 · Journal of Medicinal Chemistry
- How does lenalidomide target the chronic lymphocytic leukemia microenvironment?Arnon Philip Kater, Sanne H. Tonino, Alexander Egle, Alan G. Ramsay · 2014 · Blood
- A phase 2 study of panobinostat with lenalidomide and weekly dexamethasone in myelomaAjai Chari, Hearn Jay Cho, Amishi Dhadwal, Gillian Morgan, Lisa La, Katarzyna Zarychta, Donna Catamero, Erika Florendo, Nadege Stevens, Daniel Verina et al. · 2017 · Blood Advances
- Monitoring tumour burden and therapeutic response through analysis of circulating tumour DNA and extracellular RNA in multiple myeloma patientsSridurga Mithraprabhu, Rachel Morley, Tiffany T. Khong, Anna Kalff, Krystal Bergin, Jay Hocking, Ioanna Savvidou, Kathryn M. Bowen, Malarmathy Ramachandran, Kawa Choi et al. · 2019 · Leukemia
- Molecular glue concept solidifiesKheewoong Baek, Brenda Arlene Schulman · 2019 · Nature Chemical Biology
- RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradationNan Zhou, Álvaro Gutiérrez-Uzquiza, Xiang Yu Zheng, Renxu Chang, Dan T. Vogl, Alfred L. Garfall, Luca L Bernabei, Anita Saraf, Laurence A. Florens, Michael P. Washburn et al. · 2019 · Leukemia