Schreiber, Stuart L.

Regulation of Ferroptotic Cancer Cell Death by GPX4

Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell

Ferroptosis and cancer prognosisCell death mechanisms and regulation

Cited by 7,713

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 5,361

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell

Signaling Pathways in DiseaseCalpain Protease Function and Regulation

Cited by 4,116

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles

Subramanian, A., Narayan, R., Corsello, S. M., Peck, D. D., Natoli, T. E., Lu, X., Gould, J., Davis, J. F., Tubelli, A. A., Asiedu, J. K., et al. (2017) · Cell

Gene expression and cancer classificationBioinformatics and Genomic Networks

Cited by 3,515

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 2,820

Printing Proteins as Microarrays for High-Throughput Function Determination

MacBeath, G., & Schreiber, S. L. (2000) · Science

Advanced Biosensing Techniques and ApplicationsAdvanced Proteomics Techniques and Applications

Cited by 2,767

Active Genes Are Tri-Methylated at K4 of Histone H3

Santos-Rosa, H., Schneider, R., Bannister, A. J., Sherriff, J., Bernstein, B. E., Emre, N. C. T., Schreiber, S. L., Mellor, J., & Kouzarides, T. (2002) · Nature

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 2,138

The mechanism of action of cyclosporin A and FK506

Schreiber, S. L., & Crabtree, G. R. (1992) · Immunology Today

Signaling Pathways in DiseaseT-cell and B-cell Immunology

Cited by 2,127

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

Brown, E. J., Albers, M. W., Bum Shin, T., ichikawa, K., Keith, C. T., Lane, W. S., & Schreiber, S. L. (1994) · Nature

PI3K/AKT/mTOR signaling in cancerSignaling Pathways in Disease

Cited by 2,053

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Viswanathan, V. S., Ryan, M. J., Dhruv, H. D., Gill, S., Eichhoff, O. M., Seashore-Ludlow, B., Kaffenberger, S. D., Eaton, J. K., Shimada, K., Aguirre, A. J., et al. (2017) · Nature

Ferroptosis and cancer prognosisCancer, Lipids, and Metabolism

Cited by 2,011

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

Krönke, J., Udeshi, N. D., Narla, A., Grauman, P., Hurst, S. N., McConkey, M., Svinkina, T., Heckl, D., Comer, E., Li, X., et al. (2014) · Science

Protein Degradation and InhibitorsMultiple Myeloma Research and Treatments

Cited by 1,879

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

Taunton, J., Hassig, C. A., & Schreiber, S. L. (1996) · Science

Histone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics

Cited by 1,829

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

Hangauer, M. J., Viswanathan, V. S., Ryan, M. J., Bole, D., Eaton, J. K., Matov, A., Galeas, J., Dhruv, H. D., Berens, M. E., Schreiber, S. L., et al. (2017) · Nature

Ferroptosis and cancer prognosisCancer Cells and Metastasis

Cited by 1,799

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

Fenteany, G., Standaert, R. F., Lane, W. S., Choi, S., Corey, E. J., & Schreiber, S. L. (1995) · Science

Ubiquitin and proteasome pathwaysProtease and Inhibitor Mechanisms

Cited by 1,583

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

Schreiber, S. L. (1991) · Science

Signaling Pathways in DiseaseS100 Proteins and Annexins

Cited by 1,494

Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase

Nagy, L., Kao, H.-Y., Chakravarti, D., Lin, R. J., Hassig, C. A., Ayer, D. E., Schreiber, S. L., & Evans, R. M. (1997) · Cell

Genomics and Chromatin DynamicsHistone Deacetylase Inhibitors Research

Cited by 1,230

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

Haggarty, S. J., Koeller, K. M., Wong, J. C., Grozinger, C. M., & Schreiber, S. L. (2003) · Proceedings of the National Academy of Sciences

Histone Deacetylase Inhibitors ResearchMicrotubule and mitosis dynamics

Cited by 1,066

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

Zou, Y., Palte, M. J., Deik, A. A., Li, H., Eaton, J. K., Wang, W., Tseng, Y.-Y., Deasy, R., Kost-Alimova, M., Dančík, V., et al. (2019) · Nature Communications

Ferroptosis and cancer prognosisCancer, Hypoxia, and Metabolism

Cited by 887

The promise and peril of chemical probes

Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., Bountra, C., Brennan, P. E., Brown, P. J., Bunnage, M. E., et al. (2015) · Nature Chemical Biology

Click Chemistry and ApplicationsComputational Drug Discovery Methods

Cited by 839

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset

Seashore-Ludlow, B., Rees, M. G., Cheah, J. H., Cokol, M., Price, E. V., Coletti, M. E., Jones, V., Bodycombe, N. E., Soule, C. K., Gould, J., et al. (2015) · Cancer Discovery

Computational Drug Discovery MethodsCancer Genomics and Diagnostics

Cited by 813

Three proteins define a class of human histone deacetylases related to yeast Hda1p

Grozinger, C. M., Hassig, C. A., & Schreiber, S. L. (1999) · Proceedings of the National Academy of Sciences

Histone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics

Cited by 770

Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex

Tong, J. K., Hassig, C. A., Schnitzler, G. R., Kingston, R. E., & Schreiber, S. L. (1998) · Nature

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 692

The Rise of Molecular Glues

Schreiber, S. L. (2021) · Cell

Protein Degradation and InhibitorsSignaling Pathways in Disease

Cited by 598

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.

Chen, J., Zheng, X. F., Brown, E. J., & Schreiber, S. L. (1995) · Proceedings of the National Academy of Sciences

PI3K/AKT/mTOR signaling in cancerSignaling Pathways in Disease

Cited by 556