The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
Abstract
Controlling stem cells and their niches: Adult organs such as the intestines and skin continually renew themselves every few days or weeks. In several mammalian tissues, this renewal relies on Wnt signaling. Clevers et al. review this crucial role in stem cell self renewal. Wnt plays a pivotal role in tissue regeneration even in the earliest animals. Wnt proteins function mainly as short-range signals between adjacent cells. The short-range, spatially-constrained nature of Wnt signals underpins mammalian stem cell niche architecture and tissue self-organization. Science , this issue 10.1126/science.1248012
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Self-citationIdentification of stem cells in small intestine and colon by marker gene Lgr5
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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
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Cited by
Modeling Development and Disease with Organoids
Clevers, H. (2016) · Cell · doi:10.1016/j.cell.2016.05.082 · Cited by 3,196
Self-citationFate decision of mesenchymal stem cells: adipocytes or osteoblasts?
Chen, Q., Shou, P., Zheng, C., Jiang, M., Cao, G., Yang, Q., Cao, J., Xie, N., Velletri, T., Zhang, X., et al. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.168 · Cited by 1,156
Wnt signaling in development and tissue homeostasis
Steinhart, Z., & Angers, S. (2018) · Development · doi:10.1242/dev.146589 · Cited by 821
Reparative inflammation takes charge of tissue regeneration
Karin, M., & Clevers, H. (2016) · Nature · doi:10.1038/nature17039 · Cited by 767
Self-citationTreatment of Inflammatory Bowel Disease: A Comprehensive Review
Cai, Z., Wang, S., & Li, J. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.765474 · Cited by 675
Metadata
- Authors
- Clevers, H., Loh, K. M., & Nusse, R.
- Venue
- Science
- Published
- 2014-10-03
- Volume
- 346
- Issue
- 6205
- Pages
- 1248012-1248012
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1996583924
- Cited by
- 1,364
- References
- 104
- FWCI
- 41.98
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
