The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Mapping the Epigenetic Basis of Complex Traits
Open accessAbstract
Quantifying the impact of heritable epigenetic variation on complex traits is an emerging challenge in population genetics. Here, we analyze a population of isogenic Arabidopsis lines that segregate experimentally induced DNA methylation changes at hundreds of regions across the genome. We demonstrate that several of these differentially methylated regions (DMRs) act as bona fide epigenetic quantitative trait loci (QTL epi ), accounting for 60 to 90% of the heritability for two complex traits, flowering time and primary root length. These QTL epi are reproducible and can be subjected to artificial selection. Many of the experimentally induced DMRs are also variable in natural populations of this species and may thus provide an epigenetic basis for Darwinian evolution independently of DNA sequence changes.
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Cites
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Self-citationAssessing the Impact of Transgenerational Epigenetic Variation on Complex Traits
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Cited by
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Metadata
- Authors
- Cortijo, S., Wardenaar, R., Colomé-Tatché, M., Gilly, A., Etcheverry, M., Labadie, K., Caillieux, E., Hospital, F., Aury, J.-M., Wincker, P., Roudier, F., Jansen, R. C., Colot, V., & Johannes, F.
- Venue
- Science
- Published
- 2014-03-07
- Volume
- 343
- Issue
- 6175
- Pages
- 1145-1148
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2031225004
- Cited by
- 489
- References
- 26
- FWCI
- 20.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Cortijo, S., Wardenaar, R., Colomé-Tatché, M., Gilly, A., Etcheverry, M., Labadie, K., Caillieux, E., Hospital, F., Aury, J.-M., Wincker, P., Roudier, F., Jansen, R. C., Colot, V., & Johannes, F. (2014). Mapping the Epigenetic Basis of Complex Traits. Science. https://doi.org/10.1126/science.1248127
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