The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration
Open accessAbstract
Problems making proteins kills nerve cells: Neurodegeneration is associated with a variety of different diseases, but its cellular roots are often obscure. Ishimura et al. find that mutant mice whose brain cells start to die rapidly soon after birth have lost the function of two vital cellular components (see the Perspective by Darnell). The first is a protein that releases stalled ribosomes stuck on messenger RNA (mRNA); the second is a transfer RNA (tRNA), which reads the code for arginine in the mRNA. This tRNA is expressed predominantly in the central nervous system. The lack of the tRNA leads to increased ribosomal stalling at arginine codons, which, when left uncorrected, blocks protein synthesis and proves fatal. Science , this issue p. 455 ; see also p. 378
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“The C57BL6/J (B6J)-nmf205 mouse model has mutations in both the translation GTPase GTPBP2 and the neuronal tRNAArgUCU genes that cause neurodegeneration through ribosomal stalling (Ishimura et al., 2014, 2016).”
From Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models (2020) · cites this paper as Ishimura et al., 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890
Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
Ingolia, N. T., Ghaemmaghami, S., Newman, J. R. S., & Weissman, J. S. (2009) · Science · doi:10.1126/science.1168978 · Cited by 3,853
Ingolia, N. T., Lareau, L. F., & Weissman, J. S. (2011) · Cell · doi:10.1016/j.cell.2011.10.002 · Cited by 2,187
Ingolia, N. T., Brar, G. A., Rouskin, S., McGeachy, A. M., & Weissman, J. S. (2012) · Nature Protocols · doi:10.1038/nprot.2012.086 · Cited by 1,280
The Elongation, Termination, and Recycling Phases of Translation in EukaryotesPreprint
Dever, T. E., & Green, R. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a013706 · Cited by 561
A Novel ES Cell Line, TT2, with High Germline-Differentiating Potency
Yagi, T., Tokunaga, T., Furuta, Y., Nada, S., Yoshida, M., Tsukada, T., Saga, Y., Takeda, N., Ikawa, Y., & Aizawa, S. (1993) · Analytical Biochemistry · doi:10.1006/abio.1993.1458 · Cited by 465
Dom34 Rescues Ribosomes in 3′ Untranslated Regions
Guydosh, N. R., & Green, R. (2014) · Cell · doi:10.1016/j.cell.2014.02.006 · Cited by 370
Translational Pausing Ensures Membrane Targeting and Cytoplasmic Splicing of XBP1u mRNA
Yanagitani, K., Kimata, Y., Kadokura, H., & Kohno, K. (2011) · Science · doi:10.1126/science.1197142 · Cited by 362
Widespread Regulation of Translation by Elongation Pausing in Heat Shock
Shalgi, R., Hurt, J. A., Krykbaeva, I., Taipale, M., Lindquist, S. L., & Burge, C. B. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.11.028 · Cited by 346
Dom34:Hbs1 Promotes Subunit Dissociation and Peptidyl-tRNA Drop-Off to Initiate No-Go Decay
Shoemaker, C. J., Eyler, D. E., & Green, R. (2010) · Science · doi:10.1126/science.1192430 · Cited by 335
Gerashchenko, M. V., Lobanov, A. V., & Gladyshev, V. N. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120799109 · Cited by 302
Pisareva, V. P., Skabkin, M. A., Hellen, C. U. T., Pestova, T. V., & Pisarev, A. V. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.93 · Cited by 299
Diversity of tRNA genes in eukaryotes
Goodenbour, J. M., & Pan, T. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl725 · Cited by 240
Zhao, L., Longo-Guess, C. M., Harris, B. S., Lee, J.-W., & Ackerman, S. L. (2005) · Nature Genetics · doi:10.1038/ng1620 · Cited by 214
Self-citationRibosome rescue: tmRNA tagging activity and capacity in Escherichia coli
Moore, S. D., & Sauer, R. T. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04832.x · Cited by 128
Halting a cellular production line: responses to ribosomal pausing during translation
Buchan, J. R., & Stansfield, I. (2007) · Biology of the Cell · doi:10.1042/bc20070037 · Cited by 119
Ribosome profiling reveals features of normal and disease-associated mitochondrial translation
Rooijers, K., Loayza‐Puch, F., Nijtmans, L. G. J., & Agami, R. (2013) · Nature Communications · doi:10.1038/ncomms3886 · Cited by 101
Goldowitz, D., Frankel, W. N., Takahashi, J. S., Vitaterna, M. H., Bult, C. J., Kibbe, W. A., Snoddy, J. R., Li, Y., Pretel, S., Yates, J., et al. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.09.016 · Cited by 72
Sequence and Structure Requirements for Drosophila tRNA 5′- and 3′-End Processing
Levinger, L., Vasisht, V., Greene, V., Bourne, R., Birk, A. V., & Kolla, S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.32.18903 · Cited by 37
Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase.
Kudo, H., Senju, S., Mitsuya, H., & Nishimura, Y. (2000) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1006/bbrc.2000.2763 · Cited by 24
Self-citationWatanabe, M., Yoshida, K.-I., Hida, M., Kato, H., Uchida, K., Yamaguchi, R., Tateyama, S., & Sugano, S. (2000) · Gene · doi:10.1016/s0378-1119(00)00346-2 · Cited by 18
Levinger, L., & Serjanov, D. (2012) · RNA Biology · doi:10.4161/rna.19025 · Cited by 17
Flagged first, then by citations
Cited by
Sorted by citations
A large-scale binding and functional map of human RNA-binding proteins
Van Nostrand, E. L., Freese, P., Pratt, G. A., Wang, X., Wei, X., Xiao, R., Blue, S. M., Chen, J.-Y., Cody, N. A. L., Dominguez, D., et al. (2020) · Nature · doi:10.1038/s41586-020-2077-3 · Cited by 1,317
GtRNAdb 2.0: an expanded database of transfer RNA genes identified in complete and draft genomes
Chan, P. P., & Lowe, T. M. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1309 · Cited by 1,056
Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity
Nedialkova, D. D., & Leidel, S. A. (2015) · Cell · doi:10.1016/j.cell.2015.05.022 · Cited by 565
Ribosome collisions trigger general stress responses to regulate cell fate
Wu, C. C.-C., Peterson, A. F., Zinshteyn, B., Regot, S., & Green, R. (2020) · Cell · doi:10.1016/j.cell.2020.06.006 · Cited by 503
Emerging roles of tRNA in adaptive translation, signalling dynamics and disease
Kirchner, S., & Ignatova, Z. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3861 · Cited by 545
Metadata
- Authors
- Ishimura, R., Nagy, G., Dotu, I., Zhou, H., Yang, X.-L., Schimmel, P., Senju, S., Nishimura, Y., Chuang, J. H., & Ackerman, S. L.
- Affiliations
- Howard Hughes Medical Institute (US)
- The Jackson Laboratory for Genomic Medicine, 263 Farmington Avenue, Farmington, CT 06030, USA.
- Scripps Research Institute (US)
- Kumamoto University (JP)
- The Jackson Laboratory for Genomic Medicine (US)
- Corresponding author
- Ishimura, Ryuta
- Nagy, Gabor
- Ackerman, Susan L.
- Venue
- Science
- Published
- 2014-07-25
- Volume
- 345
- Issue
- 6195
- Pages
- 455-459
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4281038
- OpenAlex
- W1983859619
- Cited by
- 455
- References
- 22
- Citations by year
- 2026: 29 · 2025: 34 · 2024: 41 · 2023: 47 · 2022: 33 · 2021: 40 · 2020: 44 · 2019: 51 · 2018: 42 · 2017: 30 · 2016: 30 · 2015: 24 · 2014: 9
- FWCI
- 12.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- National Science Foundation
- Howard Hughes Medical Institute
- Natural Environment Research Council
- National Cancer Institute (#CA34196, P30CA034196)
- National Institute of Neurological Disorders and Stroke (R01NS085092)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- ribosome stalling, tRNA mutations, pelota, ribosome recycling, neurodegeneration
- MeSH terms
- Animals, Cell Nucleus, Cerebellum, Endonucleases, Mice, Inbred BALB C, Mice, Inbred C57BL, Microfilament Proteins, Ribosomes, RNA, Transfer, Arg, Protein Biosynthesis, Point Mutation, Cell Cycle Proteins, GTP-Binding Proteins, Neurodegenerative Diseases, RNA Splice Sites, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
