The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
A pause sequence enriched at translation start sites drives transcription dynamics in vivo
Open accessAbstract
Transcription takes a pause to consider: A short sequence in DNA causes RNA polymerase (RNAP) to pause at thousands of previously undocumented locations in the genome. Larson et al. mapped these pause sites at single-nucleotide resolution in vivo in actively growing bacteria. Transcriptional pausing can be critical for the regulation of gene expression, by allowing RNA folding events and in the recruitment of other transcription factors. Science , this issue p. 1042
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849
WebLogo: A Sequence Logo Generator: Figure 1
Crooks, G. E., Hon, G., Chandonia, J.-M., & Brenner, S. E. (2004) · Genome Research · doi:10.1101/gr.849004 · Cited by 12,386
Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection
Baba, T., Ara, T., Hasegawa, M., Takai, Y., Okumura, Y., Baba, M., Datsenko, K. A., Tomita, M., Wanner, B. L., & Mori, H. (2006) · Molecular Systems Biology · doi:10.1038/msb4100050 · Cited by 7,858
The Complete Genome Sequence of Escherichia coli K-12
Blattner, F. R., Plunkett, G., Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., et al. (1997) · Science · doi:10.1126/science.277.5331.1453 · Cited by 7,452
Higuchi, R., Krummel, B., & Saiki, R. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.15.7351 · Cited by 2,387
Coding-Sequence Determinants of Gene Expression in Escherichia coli
Kudla, G., Murray, A. W., Tollervey, D., & Plotkin, J. B. (2009) · Science · doi:10.1126/science.1170160 · Cited by 1,458
Direct observation of base-pair stepping by RNA polymerase
Abbondanzieri, E. A., Greenleaf, W. J., Shaevitz, J. W., Landick, R., & Block, S. M. (2005) · Nature · doi:10.1038/nature04268 · Cited by 855
Self-citationNascent transcript sequencing visualizes transcription at nucleotide resolution
Churchman, L. S., & Weissman, J. S. (2011) · Nature · doi:10.1038/nature09652 · Cited by 823
Self-citationRecombineering: a homologous recombination-based method of genetic engineering
Sharan, S. K., Thomason, L. C., Kuznetsov, S. G., & Court, D. L. (2009) · Nature Protocols · doi:10.1038/nprot.2008.227 · Cited by 785
Causes and effects of N-terminal codon bias in bacterial genes
Goodman, D. B., Church, G. M., & Kosuri, S. (2013) · Science · doi:10.1126/science.1241934 · Cited by 573
Research works printed but not linked: 8
- 10.1073/pnas.84.6.1507 · doi:10.1073/pnas.84.6.1507
- 10.1016/S0022-2836(05)80123-8 · doi:10.1016/s0022-2836(05)80123-8
- 10.1021/bi00046a046 · doi:10.1021/bi00046a046
- Aivazashvili V. A., Bibilashvili R. Sh., , Vartikian R. M., , Kutateladze T. A., Effect of the primary structure of RNA on the pulse character of RNA elongation in vitro by Escherichia coli RNA polymerase: A model Mol. Biol. (Mosk.) 15, 915–929 (1981). [Article in Russian] [Medline6168904
- 10.1093/nar/13.23.8425 · doi:10.1093/nar/13.23.8425
- 10.1093/nar/19.7.1671 · doi:10.1093/nar/19.7.1671
- 10.1016/S0021-9258(18)89659-4 · doi:10.1016/s0021-9258(18)89659-4
- 10.2307/2437147 · DOI
Cited by
Structure of activated transcription complex Pol II–DSIF–PAF–SPT6
Vos, S. M., Farnung, L., Boehning, M., Wigge, C., Linden, A., Urlaub, H., & Cramer, P. (2018) · Nature · doi:10.1038/s41586-018-0440-4 · Cited by 432
Mayer, A., di Iulio, J., Maleri, S., Eser, U., Vierstra, J., Reynolds, A., Sandstrom, R., Stamatoyannopoulos, J. A., & Churchman, L. S. (2015) · Cell · doi:10.1016/j.cell.2015.03.010 · Cited by 367
Coupling of RNA Polymerase II Transcription Elongation with Pre-mRNA Splicing
Saldi, T., Cortazar, M. A., Sheridan, R. M., & Bentley, D. L. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.04.017 · Cited by 258
Pause & go: from the discovery of RNA polymerase pausing to its functional implications
Mayer, A., Landry, H. M., & Churchman, L. S. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.03.002 · Cited by 125
Oswald, J., Njenga, R., Natriashvili, A., Sarmah, P., & Koch, H.-G. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.664241 · Cited by 88
Metadata
- Authors
- Larson, M. H., Mooney, R. A., Peters, J. M., Windgassen, T., Nayak, D., Gross, C. A., Block, S. M., Greenleaf, W. J., Landick, R., & Weissman, J. S.
- Venue
- Science
- Published
- 2014-05-30
- Volume
- 344
- Issue
- 6187
- Pages
- 1042-1047
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2042070371
- Cited by
- 317
- References
- 50
- FWCI
- 18.43
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A pause sequence enriched at translation start sites drives transcription dynamics in vivo. https://app.cochat.ai/papers/10.1126/science.1251871
- The paper
- Larson, M. H., Mooney, R. A., Peters, J. M., Windgassen, T., Nayak, D., Gross, C. A., Block, S. M., Greenleaf, W. J., Landick, R., & Weissman, J. S. (2014). A pause sequence enriched at translation start sites drives transcription dynamics in vivo. Science. https://doi.org/10.1126/science.1251871
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
