The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
FoxP influences the speed and accuracy of a perceptual decision in Drosophila
Abstract
Decisions take time if information gradually accumulates to a response threshold, but the neural mechanisms of integration and thresholding are unknown. We characterized a decision process in Drosophila that bears the behavioral signature of evidence accumulation. As stimulus contrast in trained odor discriminations decreased, reaction times increased and perceptual accuracy declined, in quantitative agreement with a drift-diffusion model. FoxP mutants took longer than wild-type flies to form decisions of similar or reduced accuracy, especially in difficult, low-contrast tasks. RNA interference with FoxP expression in αβ core Kenyon cells, or the overexpression of a potassium conductance in these neurons, recapitulated the FoxP mutant phenotype. A mushroom body subdomain whose development or function require the transcription factor FoxP thus supports the progression of a decision toward commitment.
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“Flies are capable of a wide array of complex behaviors, including social communication, aggression, spatial navigation, decision-making, and learning 5–9.”
From FlyWire: online community for whole-brain connectomics (2022) · cites this paper as [8]
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The Neural Basis of Decision Making
Gold, J. I., & Shadlen, M. N. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113038 · Cited by 3,764
Roitman, J. D., & Shadlen, M. N. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09475.2002 · Cited by 1,589
Motion perception: seeing and deciding.
Shadlen, M. N., & Newsome, W. T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.628 · Cited by 723
The effect of stimulus strength on the speed and accuracy of a perceptual decision
Palmer, J., Huk, A. C., & Shadlen, M. N. (2005) · Journal of Vision · doi:10.1167/5.5.1 · Cited by 691
Human-specific transcriptional regulation of CNS development genes by FOXP2
Konopka, G., Bomar, J. M., Winden, K., Coppola, G., Jonsson, Z. O., Gao, F., Peng, S., Preuss, T. M., Wohlschlegel, J. A., & Geschwind, D. H. (2009) · Nature · doi:10.1038/nature08549 · Cited by 390
Research works printed but not linked: 28
- 10.1037/0033-295X.111.2.333 · DOI
- 10.1037/0033-295X.113.4.700 · DOI
- R. D. Luce Response Times (Oxford Univ. Press New York 1986).
- 10.1038/nn1142 · DOI
- Abraham N. M., Spors H., Carleton A., Margrie T. W., Kuner T., Schaefer A. T., Maintaining accuracy at the expense of speed: Stimulus similarity defines odor discrimination time in mice. Neuron 44, 865–876 (2004).15572116
- 10.1016/j.cell.2009.08.034 · DOI · Paper page
- 10.1016/0042-6989(79)90136-6 · DOI
- 10.1016/j.neuron.2006.07.013 · DOI
- 10.1242/dev.124.4.761 · DOI
- 10.1002/cne.21692 · DOI · Paper page
- 10.1146/annurev.ne.12.030189.000341 · DOI
- 10.1016/S0896-6273(02)01092-9 · DOI · Paper page
- 10.1126/science.1089035 · DOI
- 10.1126/science.274.5295.2104 · DOI
- 10.1016/j.neuron.2013.07.045 · DOI
- 10.1016/j.cub.2012.02.014 · DOI
- 10.1038/35097076 · DOI
- 10.1093/molbev/msq182 · DOI
- 10.1016/j.cub.2008.01.060 · DOI
- 10.1038/mp.2011.105 · DOI
- 10.1126/science.1245079 · DOI
- 10.1016/j.ajhg.2010.09.017 · DOI · Paper page
- 10.1016/j.neuron.2012.05.034 · DOI
- 10.1371/journal.pbio.0050321 · DOI
- 10.1146/annurev.neuro.27.070203.144247 · DOI · Paper page
- 10.1073/pnas.0803697105 · DOI
- 10.1523/JNEUROSCI.21-05-01523.2001 · DOI
- 10.1038/nature05954 · DOI · Paper page
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FlyWire: online community for whole-brain connectomics
Dorkenwald, S., McKellar, C. E., Macrina, T., Kemnitz, N., Lee, K., Lu, R., Wu, J., Popovych, S., Mitchell, E., Nehoran, B., et al. (2022) · Nature Methods · doi:10.1038/s41592-021-01330-0 · Cited by 289
Tsao, C.-H., Chen, C.-C., Lin, C.-H., Yang, H.-Y., & Lin, S. (2018) · eLife · doi:10.7554/elife.35264 · Cited by 214
Neural circuits for evidence accumulation and decision making in larval zebrafish
Bahl, A., & Engert, F. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0534-9 · Cited by 166
Demir, M., Kadakia, N., Anderson, H. D., Clark, D. A., & Emonet, T. (2020) · eLife · doi:10.7554/elife.57524 · Cited by 103
Tastekin, I., Khandelwal, A., Tadres, D., Fessner, N. D., Truman, J. W., Zlatic, M., Cardona, A., & Louis, M. (2018) · eLife · doi:10.7554/elife.38740 · Cited by 78
Metadata
- Authors
- DasGupta, S., Ferreira, C. H., & Miesenböck, G.
- Affiliations
- Centre for Neural Circuits and Behaviour, University of Oxford, Tinsley Building, Mansfield Road, Oxford, OX1 3SR, UK.
- Venue
- Science
- Published
- 2014-05-23
- Volume
- 344
- Issue
- 6186
- Pages
- 901-904
- ISSN
- 0036-8075
- 1095-9203
- PMC
- PMC4206523
- Cited by
- 104
- References
- 5
- Language
- en
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