Drosophila mushroom bodies integrate hunger and satiety signals to control innate food-seeking behavior
Open accessAbstract
The fruit fly can evaluate its energy state and decide whether to pursue food-related cues. Here, we reveal that the mushroom body (MB) integrates hunger and satiety signals to control food-seeking behavior. We have discovered five pathways in the MB essential for hungry flies to locate and approach food. Blocking the MB-intrinsic Kenyon cells (KCs) and the MB output neurons (MBONs) in these pathways impairs food-seeking behavior. Starvation bi-directionally modulates MBON responses to a food odor, suggesting that hunger and satiety controls occur at the KC-to-MBON synapses. These controls are mediated by six types of dopaminergic neurons (DANs). By manipulating these DANs, we could inhibit food-seeking behavior in hungry flies or promote food seeking in fed flies. Finally, we show that the DANs potentially receive multiple inputs of hunger and satiety signals. This work demonstrates an information-rich central circuit in the fly brain that controls hunger-driven food-seeking behavior.
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Other aminergic systems associated with the mushroom bodies modify the neural output of the mushroom body such that food-associated stimuli are only attractive if an insect is food-deprived.
“For example, other aminergic systems associated with the mushroom bodies modify the neural output of the mushroom such that food-associated stimuli are only attractive if an insect is food-deprived [74].”
From Phenomenal interface theory: a model for basal consciousness (2025) · cites this paper as [74]
The Results sections on dopaminergic neurons and mushroom-body output neurons report that hunger-related dopamine signaling regulates flies’ food-seeking behavior and that starvation changes output-neuron responses to yeast odor. The paper also says hungry flies, rather than fed flies, approach yeast food. Its experiments concern fruit flies and yeast odor, so the claim’s broader wording about insects and food-associated stimuli is not established. (LLM, conf=0.84)
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Tastekin, I., Khandelwal, A., Tadres, D., Fessner, N. D., Truman, J. W., Zlatic, M., Cardona, A., & Louis, M. (2018) · eLife · doi:10.7554/elife.38740 · Cited by 78 · see citing works
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Phenomenal interface theory: a model for basal consciousness
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“For example, other aminergic systems associated with the mushroom bodies modify the neural output of the mushroom such that food-associated stimuli are only attractive if an insect is food-deprived [74].”
- Authors
- Tsao, C.-H., Chen, C.-C., Lin, C.-H., Yang, H.-Y., & Lin, S.
- Affiliations
- Institute of Molecular Biology, Academia Sinica (TW)
- Corresponding author
- Lin, Suewei
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2018-03-16
- Volume
- 7
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC5910021
- OpenAlex
- W2790008006
- Cited by
- 214
- References
- 131
- Citations by year
- 2026: 26 · 2025: 28 · 2024: 36 · 2023: 33 · 2022: 22 · 2021: 26 · 2020: 20 · 2019: 16 · 2018: 7
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Science and Technology, Taiwan (105-2628-B-001-005-MY3)
- Academia Sinica
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- mushroom body, hunger, satiety, food-seeking behavior, Kenyon cells, mushroom body output neurons, dopaminergic neurons, starvation, food odor, energy state, Drosophila, neural circuits
- MeSH terms
- Animals, Appetitive Behavior, Brain, Drosophila melanogaster, Feeding Behavior, Food, Hunger, Instinct, Satiety Response, Starvation, Gene Expression, Mushroom Bodies, Drosophila Proteins, Dopaminergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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