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Merging photoredox with nickel catalysis: Coupling of α-carboxyl sp 3 -carbons with aryl halides
Open accessAbstract
A bright outlook for carbon coupling: In contemporary organic chemistry, it is straightforward to forge bonds between unsaturated carbons (i.e., carbons already engaged in double bonds) using cross-coupling catalysis. The protocol runs into some trouble, however, if one or both starting carbon centers are saturated (purely single-bonded). Tellis et al. and Zuo et al. independently found that combining a second, light-activated catalyst with a nickel cross-coupling catalyst could achieve selective coupling of saturated and unsaturated reagents (see the Perspective by Lloyd-Jones and Ball). Their methods rely on single-electron transfer from the light-activated catalyst to the saturated carbon, thereby enhancing its reactivity more effectively than the twoelectron mechanisms prevailing in traditional protocols. Science , this issue p. 433 , p. 437 ; see also p. 381
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Metadata
- Authors
- Zuo, Z., Ahneman, D. T., Chu, L., Terrett, J. A., Doyle, A. G., & MacMillan, D. W. C.
- Venue
- Science
- Published
- 2014-07-25
- Volume
- 345
- Issue
- 6195
- Pages
- 437-440
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1989292538
- Cited by
- 1,611
- References
- 0
- FWCI
- 61.72
- Type
- journal article
- Language
- en
- Open access
- green
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