The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Photoredox activation of carbon dioxide for amino acid synthesis in continuous flow
Open accessAbstract
Although carbon dioxide (CO2) is highly abundant, its low reactivity has limited its use in chemical synthesis. In particular, methods for carbon–carbon bond formation generally rely on two-electron mechanisms for CO2 activation and require highly activated reaction partners. Alternatively, radical pathways accessed via photoredox catalysis could provide new reactivity under milder conditions. Here we demonstrate the direct coupling of CO2 and amines via the single-electron reduction of CO2 for the photoredox-catalysed continuous flow synthesis of α-amino acids. By leveraging the advantages of utilizing gases and photochemistry in flow, a commercially available organic photoredox catalyst effects the selective α-carboxylation of amines that bear various functional groups and heterocycles. The preliminary mechanistic studies support CO2 activation and carbon–carbon bond formation via single-electron pathways, and we expect that this strategy will inspire new perspectives on using this feedstock chemical in organic synthesis. Although the synthetic chemistry of carbon dioxide has generally been limited to two-electron pathways, single-electron mechanisms would open avenues to new reactivity. Now, the coupling of carbon dioxide and amines to produce α-amino acids can be achieved by an organic photoredox catalyst in continuous flow.
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Metadata
- Authors
- Seo, H., Katcher, M. H., & Jamison, T. F.
- Venue
- Nature Chemistry
- Published
- 2016-12-26
- Volume
- 9
- Issue
- 5
- Pages
- 453-456
- ISSN
- 1755-4330 (ISSN-L)
- 1755-4349
- OpenAlex
- W2566710433
- Cited by
- 474
- References
- 23
- FWCI
- 22.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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