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Cited by 430

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling

Open access
Jan, Calvin H., Williams, Christopher C., Weissman, Jonathan S.·2014·Science

Abstract

The wheres and whys of protein translation: Localized protein synthesis is important for a broad range of biological activities, from specifying the animal body plan to coordinating entry into the secretory pathway. Few tools are available that can investigate translation at specific subcellular sites. Jan et al. present a flexible ribosome profiling–based methodology to enable precise characterization of localized protein synthesis (see the Perspective by Shao and Hegde). Proximity-specific ribosome profiling provides a high-precision tool for looking at the mechanism of localized protein targeting and synthesis in living cells. The approach yielded a high-resolution systems-level view of cotranslational translocation at the endoplasmic reticulum. Williams et al. applied the technique to look at localized mRNA translation at the mitochondrial outer membrane. Science , this issue 10.1126/science.1257521 , p. 701 ; see also p. 748

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Metadata

Authors
Jan, C. H., Williams, C. C., & Weissman, J. S.
Venue
Science
Published
2014-11-07
Volume
346
Issue
6210
Pages
1257521-1257521
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2133469761
Cited by
430
References
6
FWCI
11.56
Type
journal article
Language
en
Open access
green

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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