SARM1 activation triggers axon degeneration locally via NAD + destruction

Gerdts, Josiah, Brace, E.J., Sasaki, Yo, DiAntonio, Aaron, Milbrandt, Jeffrey·2015·Science

DOI 10.1126/science.1258366

Cited by (594)

Items 101–200 of 594

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Fang Fang, Pei Zhuang, Xue Feng, Pingting Liu, Dong Liu, Haoliang Huang, Liang Li, Wei Chen, Liang Liu, Yang Sun et al. · 2022 · Molecular Therapy
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Andrea Loreto, Carlo Angeletti, Weixi Gu, Andrew Osborne, Bart Nieuwenhuis, Jonathan Gilley, Peter Arthur‐Farraj, Elisa Merlini, Adolfo Amici, Zhenyao Luo et al. · 2021 · eLife
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Alexander J. Davies, Simon Rinaldi, Michael Costigan, Seog Bae Oh · 2020 · Frontiers in Neuroscience
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Nicholas Peterson, Janneke D. Icso, J. Elizabeth Salisbury, Tomás Rodríguez, Paul R. Thompson, Read Pukkila-Worley · 2022 · eLife
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Jeffrey D. Nanson, Boštjan Kobe, Thomas Ve · 2018 · Journal of Leukocyte Biology
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Yao Hong, Minghui Liu, Leibo Wang, Yumeng Zu, Chou Wu, Chenyu Li, Ruoxi Zhang, Haigen Lu, Feifei Li, Shuang Xi et al. · 2022 · Cell Research
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Le Tao, Guangyue Yang, Tiantian Sun, Jie Tao, Chan Zhu, Huimin Yu, Yalan Cheng, Zongguo Yang, Mingyi Xu, Yuefeng Jiang et al. · 2023 · Journal of Hepatology
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Emil Carlsson, Jeak Ling Ding, Bernadette Byrne · 2015 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
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Xin Wang, Zi-Feng Zhang, Gui‐Hong Zheng, Aimin Wang, Chunhui Sun, Suping Qin, Juan Zhuang, Jun Lan Lu, Daifu Ma, Yuan‐Lin Zheng · 2017 · Molecules
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Hollie B. S. Griffiths, Courtney Williams, Sarah J. King, Simon J. Allison · 2020 · Biochemical Society Transactions
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Irene Llorente‐Folch, Carlos B. Rueda, Irene Pérez-Liébana, Jorgina Satrústegui, Beatriz Pardo · 2016 · Journal of Neuroscience
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Vered Shacham-Silverberg, Hadas Sar Shalom, Ron Goldner, Yarden Golan-Vaishenker, Neta Gurwicz, Irena Gokhman, Avraham Yaron · 2018 · Cell Death and Disease
An Atypical SCF-like Ubiquitin Ligase Complex Promotes Wallerian Degeneration through Regulation of Axonal Nmnat2
Yuya Yamagishi, Marc Tessier‐Lavigne · 2016 · Cell Reports
Enzymatic Functions for Toll/Interleukin-1 Receptor Domain Proteins in the Plant Immune System
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Identification of the first noncompetitive SARM1 inhibitors
Heather S. Loring, Sangram S. Parelkar, Santanu Mondal, Paul R. Thompson · 2020 · Bioorganic & Medicinal Chemistry
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Sofie Lautrup, Yujun Hou, Evandro Fei Fang, Vilhelm A. Bohr · 2023 · Cold Spring Harbor Perspectives in Medicine
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Jonathan E. Farley, Thomas C. Burdett, Romina Barría, Lukas Jakob Neukomm, Kevin Patrick Kenna, John E. Landers, Marc R. Freeman · 2018 · Proceedings of the National Academy of Sciences
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Borut Poljšak, Vito Kovač, Raja Gošnak Dahmane, Tina Levec, Andrej Starc · 2019 · Oxidative Medicine and Cellular Longevity
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Qiuzhen Lin, Wanyun Zuo, Yaozhong Liu, Keke Wu, Qiming Liu · 2021 · Clinica Chimica Acta
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Yutong Liu, Ailian Wang, Chen Chen, Qian Zhang, Qin Shen, Dan Zhang, Xueqi Xiao, Shasha Chen, Lili Lian, Zhenmin Le et al. · 2024 · Proceedings of the National Academy of Sciences
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Vassilis E. Koliatsos, Athanasios S. Alexandris · 2019 · Current Opinion in Neurology
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Keqiang Yan, Lifang Hou, Tiantian Liu, Wei Jiao, Qian Ma, Zhiqing Fang, Shimin Zhang, Daoqing Song, Jikai Liu, Xinghua Gao et al. · 2020 · Aging
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Lynn‐Jee Kim, Timothy J. Chalmers, Romanthi J. Madawala, Greg C. Smith, Catherine Li, Abhirup Das, Eric Wing Keung Poon, Jun Wang, Simon P. Tucker, David A. Sinclair et al. · 2023 · FEBS Letters
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Dziugas Sabonis, Carmel Avraham, Renee B. Chang, Allen Lu, Ehud Herbst, Arūnas Šilanskas, Deividas Vilutis, Azita Leavitt, Erez Yirmiya, Hunter C. Toyoda et al. · 2025 · Nature
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