SARM1 activation triggers axon degeneration locally via NAD + destruction

Gerdts, Josiah, Brace, E.J., Sasaki, Yo, DiAntonio, Aaron, Milbrandt, Jeffrey·2015·Science
DOI 10.1126/science.1258366

Cited by (594)

Items 501–594 of 594

  1. TIR immune signaling is blocked by phosphorylation to maintain growth in plants and animals
    Jun Li, Sisi Chen, Bo Yu, Qingzhong Li, Ruijia Liu, Zaiqing Wang, Li Wan, Yang Zhao · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  2. Pyruvate kinase activates SARM1 to exacerbate axonal degeneration in diabetic peripheral neuropathy
    Jingxuan Liu, Wenxi Li, Chenyu Li, Yuefeng Jiang, Wenjie Zhu, Zhe Zhang, Yong Juan Zhao, Jinzhong Lin, Wei Yu · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  3. SARM1 is required for macrophage immunophenotype switching that is essential for nerve repair
    Julianna Bennett, Halimah Adesunkanmi, Noah Leever, Grace Bergeron, Josh Small, C. S. Holladay, Grace Saxman, Rachel E. Williamson, Manshi Swain, Gavin Pearson et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  4. NAD+ hydrolase Sarm1 is a key driver of synapse degeneration and memory loss in Alzheimer’s disease
    Fan, Fan, Joshi, Prince, Liu, Xiaojie, Kotturu, Sandeep Kumar, Abiola, Michael, Liu, Qingsong, Lou, Xuelin · 2025
  5. Neurodegeneration takes its TOLL
    Siân Lewis · 2015 · Nature reviews. Neuroscience
  6. Restraint of the Wallenda/DLK MAP Kinase cascade by the Kinesin-3 motor regulates the assembly of synapses
    Jiaxing Li · 2017 · Deep Blue (University of Michigan)
  7. Axon Death Pathways Converge on Axed to Promote Axon Disassembly
    Thomas C. Burdett · 2017 · The Journal of the American Medical Association (JAMA) Network (American Medical Association)
  8. Regulation of Regenerative and Degenerative Responses to Axonal Injury
    Yan Hao · 2017 · Deep Blue (University of Michigan)
  9. Mechanistic Insights into Neurodegenerative Diseases: The Potential for the Development of Novel Therapeutics
    Medhane G. Cumbay, Michael LaFontaine, Sage Arbor · 2018 · Springer eBooks
  10. Consequences of Directed Mitochondrial DNA Damage in Primary Neurons
    Matthew J Geden · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  11. Amyotrophic Lateral Sclerosis (ALS): The Application of Integrative and Functional Medical Nutrition Therapy (IFMNT)
    Coco Newton · 2020 · Springer eBooks
  12. Viral Transduction of DRG Neurons
    Yo Sasaki · 2020 · Methods in molecular biology
  13. Planning and Analysis of Axon Degeneration Screening Experiments
    Lyndah E. Lovell, John C. Bramley, William Buchser · 2020 · Methods in molecular biology
  14. TIR-1/SARM1 Inhibits Axon Regeneration
    Victoria Julian · 2021 · eScholarship@UMassChan
  15. Understanding the Molecular Pathogenesis of Retinal Neurodegeneration
    Jonathan B. Lin · 2020 · Open Scholarship Institutional Repository (Washington University in St. Louis)
  16. Regenerative Therapies for Acquired Axonal Neuropathies
    Matthew Wilcox, Aysel Cetinkaya‐Fisgin, Ahmet Höke · 2020 · Springer eBooks
  17. Mechanism of axonal degeneration: from molecular signaling to the development of therapeutic applications
    Toshiyuki Araki · 2021 · Folia Pharmacologica Japonica
  18. The Development and Application of a Human Stem Cell-Based Model of Chemotherapy-Induced Neuropathy
    Andrew R. Snavely · 2018 · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
  19. A good gut feeling on Sarm1-mediated axon degeneration
    Victoria E. von Saucken, David J. Simon · 2021 · Protein & Cell
  20. ADP-ribose triggers neuronal ferroptosis by rewiring purine and pyrimidine metabolism
    Haoqi Ni, Yingying He, Peng Cui, Hebing Chen, Guoqing Lv, Huiyan Lei, Feng Wang, Qichuan Zhuge, Baodong Chen, Ling Liang et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  21. The Role of NAD+ in Rejuvenating Human Body
    Biotechnology Kiosk, Shyamasri Biswas · 2020 · Biotechnology Kiosk
  22. A nod and a Wnk to axon branching and destruction
    Owen M. Peters, Gaynor Ann Smith · 2021 · Neuron
  23. Axon maintenance and degeneration
    Fan Wang, Jing Han Yang, Zhigang He · 2020 · Elsevier eBooks
  24. Nutraceuticals for targeting NAD+ to restore mitochondrial function
    Antje Garten, Gareth Geoffrey Lavery · 2022 · Elsevier eBooks
  25. ENZYMATIC AND ENDOGENOUS SYNTHESIS OF NAD(P)‐DERIVED CALCIUM‐MOBILIZING MESSENGERS
    Hon Cheung Lee, Yong Juan Zhao · 2022
  26. The structure of NAD + consuming protein Acinetobacter baumannii TIR domain shows unique kinetics and conformations
    Erik H. Klontz, Juliet O. Obi, Yajing Wang, Gabrielle Glendening, Jahid Carr, Constantine Tsibouris, Sahthi Buddula, Shreeram C. Nallar, Alexei S. Soares, Dorothy Beckett et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  27. eLife Assessment: Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development
    Dion K. Dickman · 2023 · eLife
  28. Reviewer #3 (Public Review): Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development
    2023 · eLife
  29. Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development
    Ellen J. Guss, Yulia Akbergenova, Karen L Cunningham, J. Troy Littleton · 2023 · eLife
  30. Reviewer #1 (Public Review): Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development
    2023 · eLife
  31. Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis
    Rachel C. Clary, Blair A. Jenkins, Ellen A. Lumpkin · 2023
  32. Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis
    Rachel C. Clary, Blair A. Jenkins, Ellen A. Lumpkin · 2023
  33. Reviewer #2 (Public Review): Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis
    Clary Rachel C., Jenkins Blair A., Ellen A. Lumpkin · 2023
  34. Reviewer #1 (Public Review): Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis
    Clary Rachel C., Jenkins Blair A., Ellen A. Lumpkin · 2023
  35. Reviewer #4 (Public Review): Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis
    Rachel C. Clary, Jenkins Blair A., Ellen A. Lumpkin · 2023
  36. Reviewer #3 (Public Review): Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis
    Clary Rachel C., Jenkins Blair A., Ellen A. Lumpkin · 2023
  37. eLife Assessment: Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis
    Oren Schuldiner · 2023
  38. Local translation is engaged to sustain synaptic function in impaired Wallerian degeneration
    Maria Paglione, Leonardo Restivo, Sarah Zakhia, Arnau Llobet Rosell, Marco Terenzio, Lukas Jakob Neukomm · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  39. Lysosomal integrity suppresses TIR-1/SARM1 aggregation to restrain toxic propagation of p38 innate immunity
    Samantha Y. Tse, Read Pukkila-Worley · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  40. Metabolism and Receptor Mechanisms of Niacin Action
    Stanislav E. Boronovskiy, Копылова Вероника Сергеевна, Yaroslav R. Nartsissov · 2023 · Tsitologiya
  41. The Association Between Elevated Intraocular Pressure and Optic Nerve Damage in Glaucoma
    Robert W. Nickells · 2024 · Elsevier eBooks
  42. In vivo Morphological Dynamics of Single Laser-Axotomized Corneal Nerve Fibers in Sarm1-Null Adult Mice
    Almudena Íñigo‐Portugués, Fernando Aleixandre‐Carrera, Salvador Sala, Fernando Borrás, Jose Antonio Gomez-Sanchez, Peter Arthur‐Farraj, M. Carmen Acosta, Carlos Belmonte, Juana Gallar, Víctor Meseguer · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  43. Quantification of SARM1 activity in human peripheral blood mononuclear cells
    Lila F. Dabill, Ivana R. Shen, Jennifer M. Brazill, Alicia Neiner, Yo Sasaki, Erica L. Scheller · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  44. Synthesis and Degradation of NAD+ and Methods for Enhancing Its Levels
    Meiling Sun, Haidong Xu, Zheng‐Hong Qin · 2025 · Springer eBooks
  45. Death receptor 6 does not regulate axon degeneration and Schwann cell injury responses during Wallerian degeneration
    Bogdan Beirowski, Haoran Huang, Elisabetta Babetto · 2026 · eLife
  46. Probing Intracellular Yeast Metabolism With Deuterium Magnetic Resonance Spectroscopy
    Fatima Anum, Charbel D. Assaf, Farhad Haj Mohamad, Mariia Anikeeva, Arne Brahms, Jyotirmoy Dey, Simon Kaltenberger, Eric Beitz, Lina Welz, Victoria Annis et al. · 2025 · NMR in Biomedicine
  47. Non-Autonomous PMK-1/p38 MAPK Signaling Ensures Homeostatic Downregulation of Germline Stem Cell Proliferation in C. Elegans
    Alexandre Clouet, Matthieu Valet, Benjamin Dufour, Janina Rieger, Xavier Lechasseur, Aurelia Condomat Zoumabo, Lloyd Venceslas Fotso Dzuna, Alexane Murray, Jichao Deng, Pier-Olivier Martel et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  48. Death receptor 6 does not regulate axon degeneration and Schwann cell injury responses during Wallerian degeneration
    Bogdan Beirowski, Haoran Huang, Elisabetta Babetto · 2025 · eLife
  49. Death receptor 6 does not regulate axon degeneration and Schwann cell injury responses during Wallerian degeneration
    Bogdan Beirowski, Haoran Huang, Elisabetta Babetto · 2025 · eLife
  50. A redox-dependent switch governing sensory axon degeneration and regeneration
    Chia-Jung Hsieh, Lauryn M. Lee, Sandra Rieger · 2025 · Scientific Reports
  51. References
    2025 · Elsevier eBooks
  52. TIR-domain-containing protein C as modulator of innate immune checkpoints
    Leon Heine, Hannah Griffiths, Huiyun Hu, Isabelle Müller, Svetlana Kuhn, Luca Rudolph, Xaver Rait, Anna Waldhuber, Ying Chen, Thomas Miethke · 2025 · Scientific Reports
  53. APLP1 Interacts with SARM1 and Regulates Axonal Maintenance and Post-Injury Degeneration
    Minjae Kang, Hwigyeong Kim, Yewon Jeon, Yoon Kyung Shin, Hwan Tae Park, Jung Eun Shin · 2025 · Molecular Neurobiology
  54. Inhibition of Wallerian Degeneration Leads to Decreased Functional Recovery 6 Weeks After Delayed Repair of Transected Rat Sciatic Nerve
    Mark A. Feger, Jesse Hu, Tony Y. Lee, Christopher J. Dy, David M. Brogan · 2025 · Hand
  55. Vincristine-induced brain toxicity is reduced with prevention of peripheral axon degeneration in Sarm1 knockout mice
    Jonas Yeung, Prisca Hsu, Jordan Mak, Ali Darbandi, Anne L. Wheeler, Rosanna Weksberg, Sharon Guger, Russell James Schachar, Shinya Ito, Johann K. Hitzler et al. · 2025 · Acta Neuropathologica Communications
  56. Additional file 1 of Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological, radiological, and functional measures
    Donald V. Bradshaw, Andrew K. Knutsen, Alexandru V. Korotcov, Genevieve M. Sullivan, Kryslaine L. Radomski, Bernard J. Dardzinski, Xiaomei Zi, Dennis P. McDaniel, Regina C. Armstrong · 2021 · Figshare
  57. Additional file 1 of Genetic ablation of Sarm1 attenuates expression and mislocalization of phosphorylated TDP-43 after mouse repetitive traumatic brain injury
    Elif O. Dogan, James Bouley, Jianjun Zhong, Ashley L. Harkins, Allison M. Keeler, Daryl A. Bosco, Brown, Robert H., Nils Henninger · 2024 · Figshare
  58. PARP10 condensation inhibits viral infection via targeting NAD + homeostasis
    Xiaoxin Chen, Qi Keng Xu, Yi Liu, Zhenshuo Zhu, Ziqiu Wang, Yun Zhang, Qi Chen, Le Tian, Zhiying Yao, Zhubing Shi et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  59. Histone methyltransferase SET-18/SMYD2-mediated activation of NADase TIR-1d/SARM1 increases mtROS to promote aging
    Dongxue Xue, Xin Su, Aaron Pambu Lelo, Yongjun Zhang, Xueqing Ba, Cheng‐Gang Zou, Aohe Ma, Yao Liu, Xiaoxue Li · 2026 · iScience
  60. Death receptor 6 does not regulate axon degeneration and Schwann cell injury responses during Wallerian degeneration
    Bogdan Beirowski, Haoran Huang, Elisabetta Babetto · 2026 · eLife
  61. Increased synaptic turnover in injured cortical axons: exploring the role of SARM1 ablation
    Ensieh Izadi, William R. Bennett, JM Collins, Aidan David Bindoff, Anna Elizabeth King, Alison Canty · 2026 · Frontiers in Synaptic Neuroscience
  62. An in silico protocol for predicting genetic biomarkers in rare diseases: a case study in sporadic amyotrophic lateral sclerosis
    Ali Aguerd, Badreddine Nouadi, Abdelkarim Ezaouine, Imad Fenjar, Faiza Bennis, Fatima Chegdani · 2026 · Frontiers in Genetics
  63. TCM formula optimization for treating diabetic peripheral neuropathy: Network pharmacology, machine learning, and experimental verification
    Yang Du, Juqin Peng, Fuzhi Zhang, Qingyuan Yu, Xuezhong Zho, Kuo Yang, Junguo Ren · 2026 · Science of Traditional Chinese Medicine
  64. Evaluation de l'effet de molécules candidates dans des modèles murins de neuropathies périphériques induites par la chimiothérapie anticancéreuse
    Hichem Bouchenaki · 2020
  65. Preclinical development of curcumin-based nanoparticles for the treatment of Charcot-Marie-Tooth-1A disease
    Zeina Msheik · 2022
  66. EVT-701 : targeting electron transport chain complex I as therapeutic approach in cancer
    Raquel Luna Yolba · 2021 · theses.fr (ABES)
  67. New regulators in oxytocin and vasopressin release : role of the endolysosomal two-pore channels
    Lora L. Martucci · 2021 · theses.fr (ABES)
  68. Challenges in surface energy modulations for (moto)neurons axonal growth
    Océane Sénépart · 2022
  69. Modulation de la voie des kynurénines au cours de l'insuffisance rénale aiguë : dynamique, marqueurs et contribution à la production de NAD
    Justine Serre · 2024
  70. Study of development and regeneration of corneal innervation in transgenic mice
    Elena Bizzarri · 2024 · theses.fr (ABES)
  71. Functional and Histological Outcomes After Polyethylene Glycol Fusion of Rat Sciatic Nerve Transection
    Tony Y. Lee, Daniel A. Hunter, Ronaldo Perez, Christopher J. Dy, David M. Brogan · 2026 · The Journal Of Hand Surgery
  72. NMNAT2-SARM1 Axis Drives Redox Failure and Disrupts APP Processing in Neurons
    Andrea Enriquez, Sen Yang, Karen Ling, Paymaan Jafar‐Nejad, Hui‐Chen Lu · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  73. Compensatory transporter upregulation facilitates retinal ganglion cell survival in glaucoma after MCT2 elimination
    Kudakwashe P. Murinda, Autumn B. Morgan, Denise M. Inman · 2026 · Frontiers in Cell and Developmental Biology
  74. Eukaryotic domestication of a bacterial immune protein following horizontal transfer
    Edward M. Culbertson, Emily Cruz-Lorenzo, Jocelyn Leon Padilla, Megan Halfmann, James R. Drurey, Jeffrey J. Lange, Yao Li, Neha Garlapati, Harshitha Gompa, Benjamin R. Morehouse et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  75. RNA modifications at the crossroads of inflammation: METTL1-mediated m 7 G methylation of Sarm1 mRNA
    Kathrine S Rallis · 2026 · Epigenomics
  76. Advances in artificial metabzymes for molecular metabolism restoration in aging-related diseases
    Peihua Lin, Xi Hu, Mengyuan Zheng, Guoxin Wu, Yao Wang, Fangyuan Li, Daishun Ling · 2026 · Chemical Communications
  77. Posttraumatic Stress Disorder (PTSD) NAD/Sirtuin Deficiency and SARM1-Mediated Synaptic Vulnerability: Evidence for Accelerated Brain Aging Subtypes
    Ngo Cheung · 2026 · Cureus
  78. Neurodegenerative NMNAT2 Deficiency Promotes APP Processing in a SARM1-Dependent Manner
    Andrea Enriquez, Sen Yang, Karen Ling, Paymaan Jafar‐Nejad, Hui‐Chen Lu · 2026 · Cells
  79. Metabolic reprogramming in polyol pathway contributes to anti-inflammatory effect of glucosamine salts on synovial fibroblasts
    Junichi Okada, Rei Nakano, Nanako Kitanaka, Taku Kitanaka, Shinichi Namba, Masumi Nakano, Atsuto Naruke, Junichi Nunomura, Yoko Suwabe, Tadayoshi Konno et al. · 2026 · npj Metabolic Health and Disease
  80. hUC ‐ MSCs via β‐ NGF Alleviate Cognitive Impairment After Tibial Fracture Surgery by Regulating the STMN2 / NMNAT2 ‐ SARM1 ‐ NF ‐ κB Signaling Pathway
    Kai Wang, Fangjun Wang, Yuhan Zhang, Wenbo Li, Shuai Li, Ying Zhou, Guangkuo Ma, Ziwei Xia, Xueyan Zhou, Liwei Wang · 2026 · CNS Neuroscience & Therapeutics
  81. MyD88 ‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions
    Seshu Vardhan Pothabathula, Saurabh Mishra, Pugazhendhi Kannan, Annette Bellar, Amy Houghton Attaway, Nicole Welch, Srinivasan Dasarathy · 2026 · Immunology
  82. Regulated cell death in the nervous system: a framework for execution diversity and spatially restricted degeneration
    Laura Lossi, Marco Sbriz, Claudia Castagna, Adalberto Merighi · 2026 · Frontiers in Cell Death
  83. Nicotinamide Mononucleotide Adenylyltransferase 1 and NAD+ Homeostasis in Neuroprotection and Aging
    You Sun, Bowei Li, Zhengjiang Qian · 2026 · Metabolites
  84. Beyond NAD Depletion: SARM1-Induced ATP Collapse Involves Direct ATP Degradation and Mitochondrial Dysfunction and Is Pharmacologically Reversible
    Zhuo Chen, Zhi Ying Zhao, Zimei Zhang, Ruoyu Zhao, Linru Shen, Hon Cheung Lee, Lei Fang, Yong Juan Zhao · 2026 · Biology
  85. Structural mechanisms for ATP-mediated inhibition of human NLRP6 inflammasome
    Zhen Cui, Qingyu Sheng, Minsoo Son, Young Ah Goo, Chen Shen · 2026 · Nature Structural & Molecular Biology
  86. Direct activation of SARM1 by dsDNA is not supported by biochemical and cellular evidence
    Allison H. Kao, Biswa Prasanna Mishra, Mitchell Sorbello, Wenbin Zhang, Qinyi Zhou, Yuefeng Jiang, Veronika Masic, Paige Harten, Weixi Gu, Jian Yuan Yang et al. · 2026 · Proceedings of the National Academy of Sciences
  87. Preclinical Pharmacokinetic and Pharmacological Profiling of B339, a Novel SARM1 Inhibitor for the Treatment of Vincristine-induced Peripheral Neuropathy
    Aaditi Karnik, Girish Siddanagouda Hosmani, Sonam Dolma, Aditi Gangopadhyay, Amit Lalwani, Ramesh Babu Boga, D. Sriram, Punna Rao Ravi, Abhijeet R. Joshi · 2026 · Pharmaceutical Research
  88. Spared corticospinal neurons activate an endogenous plasticity program after partial CNS injury
    Matias Murillo, C. O’Brien, Noa Golan, Emma X Yin, Jessica Mariani, PJ Michael Deans, Novin Balafkan, Kristen Brennand, William B.J. Cafferty · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  89. NAD + depletion by catalytic TIR domains triggers a distinct form of regulated necrosis in mammalian cells
    Nino A. Espinas, Louise Lacante, Ella Hartenian, Vanessa Mack, Zhen‐Xian Niou, Hui‐Chen Lu, Petr Brož · 2026 · Proceedings of the National Academy of Sciences
  90. NAD and NADPH in Neuronal Injury and Degeneration
    Савин Святослав Сергеевич, Denis L. Atroshenko, Tatyana A. Chubar, ANASTASIA A. POMETUN, Dmitry M. Hushpulian, Sergey V. Nikulin, Bobby Thomas, Gabriel M. Kazakov, Abraham M. Brown, Richard J. Zeman et al. · 2026 · Biochemistry (Moscow)
  91. Nucleotide stress in chronic inflammatory memory: Mitochondrial DNA damage and NAD+-dependent PARP1 chromatin dynamics
    Xie Han, Ling Wu, Jiakuo Li, WeiTing Zu, Mei Zhao · 2026 · Free Radical Biology and Medicine
  92. Stacking Up: The Expanding Catalog of Filament-Forming Enzymes
    Nancy C. Horton · 2026 · Biochemistry
  93. Data set of: "The NAD+ precursor NMN activates dSarm to trigger axon degeneration in Drosophila"
    Arnau Llobet Rosell, Lukas Jakob Neukomm · 2024 · Zenodo (CERN European Organization for Nuclear Research)
  94. BindingDB Entry 50012849: Identification of the first noncompetitive SARM1 inhibitors.
    BindingDB · 2022 · UC San Diego