The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Metabolic Diversification—Independent Assembly of Operon-Like Gene Clusters in Different Plants
Abstract
Operons are clusters of unrelated genes with related functions that are a feature of prokaryotic genomes. Here, we report on an operon-like gene cluster in the plant Arabidopsis thaliana that is required for triterpene synthesis (the thalianol pathway). The clustered genes are coexpressed, as in bacterial operons. However, despite the resemblance to a bacterial operon, this gene cluster has been assembled from plant genes by gene duplication, neofunctionalization, and genome reorganization, rather than by horizontal gene transfer from bacteria. Furthermore, recent assembly of operon-like gene clusters for triterpene synthesis has occurred independently in divergent plant lineages ( Arabidopsis and oat). Thus, selection pressure may act during the formation of certain plant metabolic pathways to drive gene clustering.
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Cluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 16,184
Whole-Genome Analysis of Histone H3 Lysine 27 Trimethylation in Arabidopsis
Zhang, X., Clarenz, O., Cokus, S., Bernatavichute, Y. V., Pellegrini, M., Goodrich, J., & Jacobsen, S. E. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050129 · Cited by 767
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
Liby, K. T., Yore, M. M., & Sporn, M. B. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2129 · Cited by 637
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Huang, S., Li, R., Zhang, Z., Li, L., Gu, X., Fan, W., Lucas, W. J., Wang, X., Xie, B., Ni, P., et al. (2009) · Nature Genetics · doi:10.1038/ng.475 · Cited by 1,490
Enzyme promiscuity: A mechanistic and evolutionary perspective
Tawfik, O. K. A. D. S. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-030409-143718 · Cited by 1,355
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Biosynthesis, regulation, and domestication of bitterness in cucumber
Shang, Y., Ma, Y., Zhou, Y., Zhang, H., Duan, L., Chen, H., Zeng, J., Zhou, Q., Wang, S., Gu, W., et al. (2014) · Science · doi:10.1126/science.1259215 · Cited by 490
Genome-wide analysis of phenylpropanoid defence pathways.
NAOUMKINA, M. A., ZHAO, Q., GALLEGO‐GIRALDO, L., DAI, X., ZHAO, P. X., & DIXON, R. A. (2010) · Molecular Plant Pathology · doi:10.1111/j.1364-3703.2010.00648.x · Cited by 410
Metadata
- Authors
- Field, B., & Osbourn, A. E.
- Venue
- Science
- Published
- 2008-04-25
- Volume
- 320
- Issue
- 5875
- Pages
- 543-547
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012598119
- Cited by
- 424
- References
- 3
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- closed
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