The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.
Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance
Open accessAbstract
Existing mouse models of lethal Ebola virus infection do not reproduce hallmark symptoms of Ebola hemorrhagic fever, neither delayed blood coagulation and disseminated intravascular coagulation nor death from shock, thus restricting pathogenesis studies to nonhuman primates. Here we show that mice from the Collaborative Cross panel of recombinant inbred mice exhibit distinct disease phenotypes after mouse-adapted Ebola virus infection. Phenotypes range from complete resistance to lethal disease to severe hemorrhagic fever characterized by prolonged coagulation times and 100% mortality. Inflammatory signaling was associated with vascular permeability and endothelial activation, and resistance to lethal infection arose by induction of lymphocyte differentiation and cellular adhesion, probably mediated by the susceptibility allele Tek . These data indicate that genetic background determines susceptibility to Ebola hemorrhagic fever.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Furthermore, reduced Tie2 expression was recently associated with susceptibility to vascular complications induced by haemorrhagic Ebola virus infection in mice50.”
From Endothelial destabilization by angiopoietin-2 via integrin β1 activation (2015) · cites this paper as [50]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
Sato, T. N., Tozawa, Y., Deutsch, U., Wolburg‐Buchholz, K., Fujiwara, Y., Gendron‐Maguire, M., Gridley, T., Wolburg, H., Risau, W., & Qin, Y. (1995) · Nature · doi:10.1038/376070a0 · Cited by 1,821
Emergence of Zaire Ebola Virus Disease in Guinea
Baize, S., Pannetier, D., Oestereich, L., Rieger, T., Koivogui, L., Magassouba, N., Soropogui, B., Sow, M. S., Keïta, S., De Clerck, H., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1404505 · Cited by 1,366
Vascular Dysmorphogenesis Caused by an Activating Mutation in the Receptor Tyrosine Kinase TIE2
Vikkula, M., Boon, L. M., Carraway, K. L., Calvert, J. T., Diamonti, A. J., Goumnerov, B. C., Pasyk, K. A., Marchuk, D. A., Warman, M. L., Cantley, L. C., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81814-0 · Cited by 797
The Genome Architecture of the Collaborative Cross Mouse Genetic Reference Population
Collaborative Cross Consortium (2012) · Genetics · doi:10.1534/genetics.111.132639 · Cited by 480
Subspecific origin and haplotype diversity in the laboratory mouse
Yang, H., Wang, J., Didion, J. P., Buus, R. J., Bell, T. A., Welsh, C. E., Bonhomme, F., Yu, A. H.-T., Nachman, M. W., Piálek, J., et al. (2011) · Nature Genetics · doi:10.1038/ng.847 · Cited by 459
Human asymptomatic Ebola infection and strong inflammatory response
Leroy, E. M., Baize, S., Volchkov, V. E., Fisher‐Hoch, S., Mc, G.-C., Lansoud-Soukate, J., Capron, M., Debré, P., Aj, G., & McCormick, J. B. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02405-3 · Cited by 409
Geisbert, T. W., Young, H. A., Jahrling, P. B., Davis, K. J., Kagan, E., & Hensley, L. E. (2003) · The Journal of Infectious Diseases · doi:10.1086/379724 · Cited by 373
Pathogenesis of Experimental Ebola Virus Infection in Guinea Pigs
Connolly, B., Steele, K. E., Davis, K. J., Geisbert, T. W., Kell, W. M., Jaax, N. K., & Jahrling, P. B. (1999) · The Journal of Infectious Diseases · doi:10.1086/514305 · Cited by 308
Roberts, A., de Villena, F. P., Wang, W., McMillan, L., & Threadgill, D. W. (2007) · Mammalian Genome · doi:10.1007/s00335-007-9045-1 · Cited by 251
Ebola Viral Disease Outbreak—West Africa, 2014
Dixon, M. G., & Schafer, I. J. (2014) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2014.10.010 · Cited by 236
Flagged first, then by citations
1 of the 28 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–200 of 301
Anti-angiogenic Targets: Angiopoietin and Angiopoietin Receptors
Kiss, E. A., & Saharinen, P. (2019) · Springer eBooks · doi:10.1007/978-3-319-33673-2_4 · Cited by 28
Diversity Outbred: A New Generation of Mouse Model
Schmidt, C. W. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.123-a64 · Cited by 28
Changing antibiotic resistance: sustainability transformation to a pro-microbial planet
Jørgensen, P. S., Wernli, D., Folke, C., & Carroll, S. P. (2017) · Current Opinion in Environmental Sustainability · doi:10.1016/j.cosust.2017.07.008 · Cited by 29
Host Transcriptional Response to Ebola Virus Infection
Speranza, E. E., & Connor, J. H. (2017) · Vaccines · doi:10.3390/vaccines5030030 · Cited by 28
Graham, J. B., Swarts, J. L., Leist, S. R., Schäfer, A., Menachery, V. D., Gralinski, L. E., Jeng, S., Miller, D. R., Mooney, M. A., McWeeney, S. K., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009287 · Cited by 27
Self-citationAnimal Models of Human Disease
Green, S. (2024) · Cambridge University Press eBooks · doi:10.1017/9781009025836 · Cited by 27
Jiang, C., Zhou, Z., Quan, Y., Zhang, S., Wang, T., Zhao, X., Morrison, C. R., Heise, M. T., He, W., Miller, M. S., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.031 · Cited by 25
Self-citationSingle-Nucleotide Polymorphisms in Human NPC1 Influence Filovirus Entry Into Cells
Kondoh, T., Letko, M. C., Munster, V. J., Manzoor, R., Maruyama, J., Furuyama, W., Miyamoto, H., Shigeno, A., Fujikura, D., Takadate, Y., et al. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy248 · Cited by 25
Self-citationEbola Immunity: Gaining a Winning Position in Lightning Chess
Ploquin, A., Zhou, Y., & Sullivan, N. J. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700827 · Cited by 26
Small animal models of filovirus disease: recent advances and future directions
Cross, R. W., Fenton, K. A., & Geisbert, T. W. (2018) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2018.1527827 · Cited by 25
Pathophysiology of Ebola Virus Infection: Current Challenges and Future Hopes
Rivera, A., & Messaoudi, I. (2015) · ACS Infectious Diseases · doi:10.1021/id5000426 · Cited by 25
Prasad, N., Novak, J. E., & Patel, M. R. (2019) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2019.01.006 · Cited by 25
Targeting Tie2 and the host vascular response in sepsis
Parikh, S. M. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf5537 · Cited by 23
Small Animal Models for Studying Filovirus Pathogenesis
Yamaoka, S., Banadyga, L., Bray, M., & Ebihara, H. (2017) · Current topics in microbiology and immunology · doi:10.1007/82_2017_9 · Cited by 24
Of mice and men: the host response to influenza virus infection
Kollmus, H., Pilzner, C., Leist, S. R., Heise, M. T., Geffers, R., & Schughart, K. (2018) · Mammalian Genome · doi:10.1007/s00335-018-9750-y · Cited by 24
Self-citationModeling pathogenesis of emergent and pre-emergent human coronaviruses in mice
Cockrell, A. S., Leist, S. R., Douglas, M. G., & Baric, R. S. (2018) · Mammalian Genome · doi:10.1007/s00335-018-9760-9 · Cited by 23
Self-citationLorè, N. I., Sipione, B., He, G., Strug, L. J., Atamni, H. J. A., Dorman, A., Mott, R., Iraqi, F. A., & Bragonzi, A. (2020) · mBio · doi:10.1128/mbio.00097-20 · Cited by 23
Jankeel, A., Menicucci, A. R., Woolsey, C. B., Fenton, K. A., Mendoza, N., Versteeg, K. M., Cross, R. W., Geisbert, T. W., & Messaoudi, I. (2020) · Journal of Virology · doi:10.1128/jvi.00250-20 · Cited by 22
Ebola virus VP35 hijacks the PKA-CREB1 pathway for replication and pathogenesis by AKIP1 association
Zhu, L., Gao, T., Huang, Y. P., Jin, J., Wang, D., Zhang, L., Jin, Y., Li, P., Hu, Y., Wu, Y. L., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29948-4 · Cited by 23
Oreper, D., Cai, Y., Tarantino, L. M., de Villena, F. P., & Valdar, W. S. J. (2017) · G3 Genes Genomes Genetics · doi:10.1534/g3.117.041491 · Cited by 20
A Multitrait Locus Regulates Sarbecovirus Pathogenesis
Schäfer, A., Leist, S. R., Gralinski, L. E., Martinez, D. R., Winkler, E. S., Okuda, K., Hawkins, P., Gully, K. L., Graham, R. L., Scobey, D. T., et al. (2022) · mBio · doi:10.1128/mbio.01454-22 · Cited by 22
Self-citationGenomic Signatures of Emerging Viruses: A New Era of Systems Epidemiology
Rasmussen, A. L., & Katze, M. G. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.04.016 · Cited by 22
Self-citationManf/ewsr1/anxa6 pathway might as the bridge between hypolipidemia and major depressive disorder
Xu, K., Zheng, P., Zhao, S., Wang, M., Tu, D., Wei, Q., Feng, J., Wang, H., Chen, J., & Xie, P. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02287-0 · Cited by 22
The source of individual heterogeneity shapes infectious disease outbreaks
Elie, B., Selinger, C., & Alizon, S. (2022) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2022.0232 · Cited by 19
Network-based analysis of the sphingolipid metabolism in hypertension
Fenger, M., Linneberg, A. R., & Jeppesen, J. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00084 · Cited by 21
Small Animal Models for Evaluating Filovirus Countermeasures
Banadyga, L., Wong, G., & Qiu, X. (2018) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.7b00266 · Cited by 21
Genetic control of alphavirus pathogenesis
Baxter, V. K., & Heise, M. T. (2018) · Mammalian Genome · doi:10.1007/s00335-018-9776-1 · Cited by 21
Self-citationDiverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross
Martin, M. D., Sompallae, R., Winborn, C. S., Harty, J. T., & Badovinac, V. P. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.072 · Cited by 21
Inter-individual variation in health and disease associated with pulmonary infectious agents
Verhein, K. C., Vellers, H. L., & Kleeberger, S. R. (2018) · Mammalian Genome · doi:10.1007/s00335-018-9733-z · Cited by 24
Ebola and Marburg Virus Infection in Bats Induces a Systemic Response
Jayaprakash, A. D., Ronk, A. J., Prasad, A. N., Covington, M. F., Stein, K. R., Schwarz, T. M., Hekmaty, S., Fenton, K. A., Geisbert, T. W., Basler, C. F., et al. (2020) · Viruses · doi:10.3390/v15020350 · Cited by 18
Suwanmanee, T., Ferris, M. T., Hu, P., Gui, T., Montgomery, S. A., de Villena, F. P., & Kafri, T. (2017) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2017.03.009 · Cited by 18
Self-citationScoggin, K., Lynch, R., Gupta, J., Nagarajan, A., Sheffield, M., Elsaadi, A. M., Bowden, C., Aminian, M., Peterson, A., Adams, L. G., et al. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010075 · Cited by 18
Wherry, E. J., & Masopust, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800964-2.00005-7 · Cited by 25
Generation and Characterization of a Mouse-Adapted Makona Variant of Ebola Virus
Chan, M., Leung, A., Griffin, B. D., Vendramelli, R., Tailor, N., Tierney, K. J., Audet, J., & Kobasa, D. (2019) · Viruses · doi:10.3390/v11110987 · Cited by 19
Genetic Mapping of Behavioral Traits Using the Collaborative Cross Resource
Wei, X., Zhang, L., Zhang, Y., Sun, X., Wang, J., Li, X., Zhang, L., Wang, X., Morahan, G., & Qin, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010682 · Cited by 18
Host Factors in Ebola Infection
Rasmussen, A. L. (2016) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-083115-022446 · Cited by 18
Self-citationIdentifying genes for neurobehavioural traits in rodents: progress and pitfalls
Baud, A., & Flint, J. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.027789 · Cited by 18
Mechanisms of Immunity in Post-Exposure Vaccination against Ebola Virus Infection
Bradfute, S. B., Anthony, S. M., Stuthman, K. S., Ayithan, N., Tailor, P. B., Shaia, C., Bray, M., Ozato, K., & Bavari, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118434 · Cited by 17
Sterken, M. G., van Sluijs, L., Wang, Y. A., Ritmahan, W., Gultom, M. L., Riksen, J. A. G., Volkers, R. J. M., Snoek, B. L., Pijlman, G. P., & Kammenga, J. E. (2021) · Journal of Virology · doi:10.1128/jvi.02430-20 · Cited by 15
Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice
Brown, A. J., Won, J. J., Wolfisberg, R., Fahnøe, U., Catanzaro, N., West, A., Moreira, F. R., Batista, M. N., Ferris, M. T., Linnertz, C. L., et al. (2023) · Hepatology · doi:10.1097/hep.0000000000000547 · Cited by 16
Self-citationEmerging Concepts and Technologies for the Discovery of Microorganisms Involved in Human Disease
Bullman, S., Meyerson, M. M., & Kostic, A. D. (2016) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012615-044305 · Cited by 16
Humanized Mice in Translational Immunology
Brehm, M. A., Bortell, R., Verma, M. K., Shultz, L. D., & Greiner, D. L. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801577-3.00012-5 · Cited by 18
Host Factors Involved in Ebola Virus Replication
Rasmussen, A. L. (2017) · Current topics in microbiology and immunology · doi:10.1007/82_2017_27 · Cited by 15
Self-citationDobbins, G. C., Patki, A., Chen, D., Tiwari, H. K., Hendrickson, R. C., Britt, W. J., Fowler, K. B., Chen, J. Y., Boppana, S. B., & Ross, S. A. (2019) · BMC Infectious Diseases · doi:10.1186/s12879-019-4681-0 · Cited by 16
Green, R. R., Wilkins, C. R., Thomas, S., Sekine, A., Ireton, R. C., Ferris, M. T., Hendrick, D., Voss, K., de Villena, F. P., Baric, R. S., et al. (2016) · Genomics Data · doi:10.1016/j.gdata.2016.10.006 · Cited by 15
Self-citationSaharinen, P., Jeltsch, M., Santoyo, M. M., Leppänen, V., & Alitalo, K. K. (2015) · Springer eBooks · doi:10.1007/978-3-319-11888-8_16 · Cited by 18
(2019) · Springer eBooks · doi:10.1007/978-3-319-33673-2 · Cited by 15
Human reconstructed kidney models
Kishi, S., Matsumoto, T., Ichimura, T., & Brooks, C. R. (2021) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-021-00548-8 · Cited by 14
Shorter, J. R., Maurizio, P. L., Bell, T. A., Shaw, G. D., Miller, D. R., Gooch, T. J., Spence, J. S., McMillan, L., Valdar, W. S. J., & de Villena, F. P. (2019) · G3 Genes Genomes Genetics · doi:10.1534/g3.118.200847 · Cited by 14
Self-citationZohud, O., Lone, I. M., Nashef, A., & Iraqi, F. A. (2023) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12367 · Cited by 13
Enfermedad por virus ebola: actualización
Calle, F., Arsuaga-Vicente, M., Mora-Rillo, M., Arnalich, F., & Arribas, J. R. (2016) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1016/j.eimc.2015.11.013 · Cited by 12
The role of Sp140 revealed in IgE and mast cell responses in Collaborative Cross mice
Matsushita, K., Li, X., Nakamura, Y., Dong, D., Mukai, K., Tsai, M. M., Montgomery, S. B., & Galli, S. J. (2021) · JCI Insight · doi:10.1172/jci.insight.146572 · Cited by 13
Konganti, K., Ehrlich, A., Rusyn, I., & Threadgill, D. W. (2018) · G3 Genes Genomes Genetics · doi:10.1534/g3.118.200230 · Cited by 13
Role of Type I Interferons on Filovirus Pathogenesis
Escudero-Pérez, B., & Muñoz‐Fontela, C. (2019) · Vaccines · doi:10.3390/vaccines7010022 · Cited by 13
Ebola-Associated Genes in the Human Genome: Implications for Novel Targets
Narayanan, R. (2014) · MOJ Proteomics & Bioinformatics · doi:10.15406/mojpb.2014.01.00032 · Cited by 12
Mapping of susceptibility loci for Ebola virus pathogenesis in mice
Schäfer, A., Marzi, A., Furuyama, W., Catanzaro, N., Nguyen, C., Haddock, E., Feldmann, F., Meade-White, K. D., Thomas, T., Hubbard, M. L., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114127 · Cited by 11
Self-citationNagarajan, A., Scoggin, K., Gupta, J., Aminian, M., Adams, L. G., Kirby, M. J. L., Threadgill, D. W., & Andrews‐Polymenis, H. L. (2024) · PLoS Genetics · doi:10.1371/journal.pgen.1011229 · Cited by 12
Molecular determinants of cross-species transmission in emerging viral infections
Wickenhagen, A., van Tol, S., & Munster, V. J. (2024) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00001-23 · Cited by 12
Ogbaini-Emovon, E., Akpede, G. O., Okogbenin, S. A., Osagiede, E. F., Tobin, E. A., Asogun, D., Okokhere, P. O., Okonofua, M. O., Akpede, N., Akhideno, P. E., et al. (2024) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofae575 · Cited by 12
Animal Model Alternatives in Filovirus and Bornavirus Research
Widerspick, L., Steffen, J. F., Tappe, D., & Muñoz‐Fontela, C. (2023) · Viruses · doi:10.3390/v15010158 · Cited by 12
Gabriel, G., Feldmann, F., Reimer, R., Thiele, S., Fischer, M., Hartmann, E., Bäder, M., Ebihara, H., Hoenen, T., & Feldmann, H. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv240 · Cited by 12
Self-citationQi, F., Chen, X., Wang, J., Niu, X., Li, S., Huang, S., & Ran, X. (2024) · Virulence · doi:10.1080/21505594.2024.2382762 · Cited by 11
Green, R. R., Wilkins, C. R., Thomas, S., Sekine, A., Ireton, R. C., Ferris, M. T., Hendrick, D., Voss, K., de Villena, F. P., Baric, R. S., et al. (2016) · Genomics Data · doi:10.1016/j.gdata.2016.10.005 · Cited by 11
Self-citationEbola Therapeutic Study and Future Directions
Lu, D.-Y., Wu, H., Yarla, N. S., Lu, T.-R., Xu, B., & Jian-Ding (2018) · Infectious Disorders - Drug Targets · doi:10.2174/1871526518666180813160348 · Cited by 11
Modulation of immune response in Ebola virus disease
Banerjee, G., Shokeen, K., Chakraborty, N., Agarwal, S., Mitra, A., Kumar, S., & Banerjee, P. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.07.004 · Cited by 11
Translational research on influenza virus infection using a nonhuman primate model
Itoh, Y. (2016) · Pathology International · doi:10.1111/pin.12385 · Cited by 12
Immune predictors of mortality following RNA virus infection
Graham, J. B., Swarts, J. L., Menachery, V. D., Gralinski, L. E., Schäfer, A., Plante, K. S., Morrison, C. R., Voss, K., Green, R. R., Choonoo, G., et al. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiz531 · Cited by 12
Self-citationComparison of tissue tropism and host response to enteric and respiratory enteroviruses
Filipe, I. C., Tee, H. K., Prados, J., Piuz, I., Constant, S., Huang, S., & Tapparel, C. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010632 · Cited by 10
CC002/Unc females are mouse models of exercise-induced paradoxical fat response
McMullan, R., Ferris, M. T., Bell, T. A., Menachery, V. D., Baric, R. S., Hua, K., Pomp, D., Smith‐Ryan, A. E., & de Villena, F. P. (2018) · Physiological Reports · doi:10.14814/phy2.13716 · Cited by 10
Self-citationHost genetic control of natural killer cell diversity revealed in the Collaborative Cross
Dupont, M. S. J., Guillemot, V., Campagne, P., Serafini, N., Marie, S., Montagutelli, X., Santo, J. P. D., & Vosshenrich, C. A. J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2018834118 · Cited by 10
Scoggin, K., Gupta, J., Lynch, R., Nagarajan, A., Aminian, M., Peterson, A., Adams, L. G., Kirby, M., Threadgill, D. W., & Andrews‐Polymenis, H. L. (2022) · mBio · doi:10.1128/mbio.01120-22 · Cited by 9
Lilue, J., Doran, A., Fiddes, I. T., Abrudan, M. I., Armstrong, J. C., Bennett, R., Chow, W., Collins, J., Collins, S. C., Czechanski, A., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/235838 · Cited by 10
Self-citationSpengler, J. R., Welch, S. R., Ritter, J. M., Harmon, J. R., Coleman-McCray, J. D., Genzer, S. C., Seixas, J. N., Scholte, F. E. M., Davies, K. A., Bradfute, S. B., et al. (2022) · Antiviral Research · doi:10.1016/j.antiviral.2022.105496 · Cited by 9
Alugupalli, K. R., Kothari, S., Cravens, M. P., Walker, J. A., Dougharty, D., Dickinson, G. S., Gatto, L. A., Bäumler, A. J., Wangdi, T., Miller, D. R., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-27400-1 · Cited by 9
Self-citationGenetic diversity drives extreme responses to traumatic brain injury and post-traumatic epilepsy
Shannon, T., Cotter, C., Fitzgerald, J., Houle, S., Levine, N., Shen, Y., Rajjoub, N., Dobres, S., Iyer, S., Xenakis, J. G., et al. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114677 · Cited by 9
Graham, J. B., Swarts, J. L., Leist, S. R., Schäfer, A., Bell, T. A., Hock, P., Farrington, J., Shaw, G. D., Ferris, M. T., de Villena, F. P., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109103 · Cited by 11
Self-citationSystems biology: A tool for charting the antiviral landscape
Bowen, J. R., Ferris, M. T., & Suthar, M. S. (2016) · Virus Research · doi:10.1016/j.virusres.2016.01.005 · Cited by 9
Self-citationGillespie, A., Teoh, J. J., Lee, H. J., Prince, J. L., Stadnisky, M. D., Anderson, M. R., Nash, W., Rival, C. M., Wei, H., Gamache, A., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005419 · Cited by 9
New tools for the visualization of biological pathways
Ghosh, T., Ma, X., & Kirby, M. J. L. (2017) · Methods · doi:10.1016/j.ymeth.2017.09.006 · Cited by 9
Advances in marmoset and mouse models buoy Ebola research
Willyard, C. (2014) · Nature Medicine · doi:10.1038/nm1214-1356 · Cited by 9
Lewis, C. E., Pinette, M. M., Lakin, S. M., Smith, G. A., Fisher, M., Moffat, E., Embury‐Hyatt, C., & Pickering, B. (2024) · Transboundary and Emerging Diseases · doi:10.1155/2024/5350769 · Cited by 8
Warner, B. M. (2021) · Pathogens · doi:10.3390/pathogens10030275 · Cited by 7
Kumar, S., Bhushan, B., Kumar, A., Panigrahi, M., Bharati, J., Kumari, S., Kaisa, K., Banik, S., Karthikeyan, A. S., Chaudhary, R., et al. (2023) · Veterinary Research Communications · doi:10.1007/s11259-023-10262-3 · Cited by 8
History and impact of the mouse-adapted Ebola virus model
Bradfute, S. B. (2022) · Antiviral Research · doi:10.1016/j.antiviral.2022.105493 · Cited by 8
Xu, K., Zheng, P., Zhao, S., Feng, J., Pu, J., Wang, J., Zhao, S., Wang, H., Chen, J., & Xie, P. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.05.044 · Cited by 10
Genetic loci regulate Sarbecovirus pathogenesis: A comparison across mice and humans
Schäfer, A., Gralinski, L. E., Leist, S. R., Hampton, B. K., Mooney, M. A., Jensen, K., Graham, R. L., Agnihothram, S., Jeng, S., Chamberlin, S. R., et al. (2024) · Virus Research · doi:10.1016/j.virusres.2024.199357 · Cited by 8
Self-citationGale, P., Simons, R. R. L., Horigan, V., Snary, E., Fooks, A. R., & Drew, T. W. (2015) · Journal of Applied Microbiology · doi:10.1111/jam.12973 · Cited by 8
Baker, C. N., Duso, D. K., Kothapalli, N. R., Hart, T., Casey, S., Cookenham, T. S., Kummer, L. W., Hvizdos, J., Lanzer, K. G., Vats, P., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-77087-1 · Cited by 7
Exploring adjunctive therapies for cerebral malaria
Bensalel, J., & Gallego‐Delgado, J. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1347486 · Cited by 11
Xu, K., Zhao, S., Ren, Y., Zhong, Q., Feng, J., Tu, D., Wu, W., Wang, J., Chen, J., & Xie, P. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02916-w · Cited by 7
Oliveira, T. Y., Merkenschlager, J., Eisenreich, T., Bortolatto, J., Yao, K.-H., Gatti, D. M., Churchill, G. A., Nussenzweig, M. C., & Breton, G. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114296 · Cited by 7
The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases
Maurizio, P. L., & Ferris, M. T. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6427-7_28 · Cited by 7
Self-citationDalaijamts, C., Cichocki, J. A., Luo, Y., Rusyn, I., & Chiu, W. A. (2021) · Toxicological Sciences · doi:10.1093/toxsci/kfab057 · Cited by 7
Jana, A., & Karanth, K. P. (2022) · Conservation Genetics · doi:10.1007/s10592-022-01479-x · Cited by 7
Collaborative cross strain CC011/UncJ as a novel mouse model of T2-high, severe asthma
Donoghue, L. J., McFadden, K. M., Vargas, D., Smith, G. J., Immormino, R. M., Moran, T. P., & Kelada, S. N. P. (2023) · Respiratory Research · doi:10.1186/s12931-023-02453-y · Cited by 7
Bourdon, M., Manet, C., Conquet, L., Parra, C. R., Kornobis, É., Bonnefoy, E., & Montagutelli, X. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011446 · Cited by 7
Western African Ebola virus epidemic
Anis, O. (2019) · WikiJournal of Medicine · doi:10.15347/wjm/2019.001 · Cited by 7
Liver Sinusoidal Endothelial Cells: An Antiviral “Defendothelium”
Klenerman, P., & Ramamurthy, N. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.12.010 · Cited by 7
Building towards a multi-dimensional genetic architecture in Caenorhabditis elegans
Sterken, M. G. (2016) · doi:10.18174/386549 · Cited by 7
Boyce, A. M., & Garibaldi, B. T. (2019) · Health Security · doi:10.1089/hs.2018.0108 · Cited by 6
Metadata
- Authors
- Rasmussen, A. L., Okumura, A., Ferris, M. T., Green, R., Feldmann, F., Kelly, S. M., Scott, D. P., Safronetz, D., Haddock, E., LaCasse, R., Thomas, M. J., Sova, P., Carter, V. S., Weiss, J. M., Miller, D. R., Shaw, G. D., Korth, M. J., Heise, M. T., Baric, R. S., de Villena, F. P.-M., Feldmann, H., & Katze, M. G.
- Affiliations
- University of Washington (US)
- National Institutes of Health (US)
- University of North Carolina at Chapel Hill (US)
- Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
- Corresponding author
- Rasmussen, Angela L.
- Okumura, Atsushi
- Katze, Michael G.
- ORCID
- Venue
- Science
- Published
- 2014-11-21
- Volume
- 346
- Issue
- 6212
- Pages
- 987-991
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4241145
- OpenAlex
- W1986492410
- Cited by
- 290
- References
- 28
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 19 · 2023: 23 · 2022: 22 · 2021: 22 · 2020: 13 · 2019: 27 · 2018: 24 · 2017: 39 · 2016: 44 · 2015: 34 · 2014: 11
- FWCI
- 29.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health (P51OD010425)
- National Institute of Allergy and Infectious Diseases (U54AI081680, U19AI100625, U19AI109761)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- Ebola virus, hemorrhagic fever, host genetic variation, Collaborative Cross mice, recombinant inbred mouse strains, disease susceptibility, disseminated intravascular coagulation, coagulation, shock, lymphocyte differentiation, endothelial activation, vascular permeability, inflammatory signaling
- MeSH terms
- Alleles, Animals, Blood Coagulation, Capillary Permeability, Disease Models, Animal, Endothelium, Vascular, Liver, Lymphocyte Activation, Mice, Inbred C57BL, Neovascularization, Physiologic, Hemorrhagic Fever, Ebola, Genetic Predisposition to Disease, Receptor, TIE-2, Mice, Host-Pathogen Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review