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Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance
Open accessAbstract
Existing mouse models of lethal Ebola virus infection do not reproduce hallmark symptoms of Ebola hemorrhagic fever, neither delayed blood coagulation and disseminated intravascular coagulation nor death from shock, thus restricting pathogenesis studies to nonhuman primates. Here we show that mice from the Collaborative Cross panel of recombinant inbred mice exhibit distinct disease phenotypes after mouse-adapted Ebola virus infection. Phenotypes range from complete resistance to lethal disease to severe hemorrhagic fever characterized by prolonged coagulation times and 100% mortality. Inflammatory signaling was associated with vascular permeability and endothelial activation, and resistance to lethal infection arose by induction of lymphocyte differentiation and cellular adhesion, probably mediated by the susceptibility allele Tek . These data indicate that genetic background determines susceptibility to Ebola hemorrhagic fever.
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“Furthermore, reduced Tie2 expression was recently associated with susceptibility to vascular complications induced by haemorrhagic Ebola virus infection in mice50.”
From Endothelial destabilization by angiopoietin-2 via integrin β1 activation (2015) · cites this paper as [50]
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Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
Sato, T. N., Tozawa, Y., Deutsch, U., Wolburg‐Buchholz, K., Fujiwara, Y., Gendron‐Maguire, M., Gridley, T., Wolburg, H., Risau, W., & Qin, Y. (1995) · Nature · doi:10.1038/376070a0 · Cited by 1,821
Emergence of Zaire Ebola Virus Disease in Guinea
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Vascular Dysmorphogenesis Caused by an Activating Mutation in the Receptor Tyrosine Kinase TIE2
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The Genome Architecture of the Collaborative Cross Mouse Genetic Reference Population
Collaborative Cross Consortium (2012) · Genetics · doi:10.1534/genetics.111.132639 · Cited by 480
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Human asymptomatic Ebola infection and strong inflammatory response
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Muñoz-Fontela, C., Dowling, W. E., Funnell, S. G. P., Gsell, P.-S., Riveros-Balta, A. X., Albrecht, R. A., Andersen, H., Baric, R. S., Carroll, M. W., Cavaleri, M., et al. (2020) · Nature · doi:10.1038/s41586-020-2787-6 · Cited by 798
Self-citationTherapeutic targeting of the angiopoietin–TIE pathway
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Self-citationAnimal Models are Essential to Biological Research: Issues and Perspectives
Barré‐Sinoussi, F., & Montagutelli, X. (2015) · Future Science OA · doi:10.4155/fso.15.63 · Cited by 459
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Metadata
- Authors
- Rasmussen, A. L., Okumura, A., Ferris, M. T., Green, R., Feldmann, F., Kelly, S. M., Scott, D. P., Safronetz, D., Haddock, E., LaCasse, R., Thomas, M. J., Sova, P., Carter, V. S., Weiss, J. M., Miller, D. R., Shaw, G. D., Korth, M. J., Heise, M. T., Baric, R. S., de Villena, F. P.-M., Feldmann, H., & Katze, M. G.
- Affiliations
- University of Washington (US)
- National Institutes of Health (US)
- University of North Carolina at Chapel Hill (US)
- Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
- Corresponding author
- Rasmussen, Angela L.
- Okumura, Atsushi
- Katze, Michael G.
- ORCID
- Venue
- Science
- Published
- 2014-11-21
- Volume
- 346
- Issue
- 6212
- Pages
- 987-991
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4241145
- OpenAlex
- W1986492410
- Cited by
- 290
- References
- 28
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 19 · 2023: 23 · 2022: 22 · 2021: 22 · 2020: 13 · 2019: 27 · 2018: 24 · 2017: 39 · 2016: 44 · 2015: 34 · 2014: 11
- FWCI
- 29.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health (P51OD010425)
- National Institute of Allergy and Infectious Diseases (U54AI081680, U19AI100625, U19AI109761)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- Ebola virus, hemorrhagic fever, host genetic variation, Collaborative Cross mice, recombinant inbred mouse strains, disease susceptibility, disseminated intravascular coagulation, coagulation, shock, lymphocyte differentiation, endothelial activation, vascular permeability, inflammatory signaling
- MeSH terms
- Alleles, Animals, Blood Coagulation, Capillary Permeability, Disease Models, Animal, Endothelium, Vascular, Liver, Lymphocyte Activation, Mice, Inbred C57BL, Neovascularization, Physiologic, Hemorrhagic Fever, Ebola, Genetic Predisposition to Disease, Receptor, TIE-2, Mice, Host-Pathogen Interactions
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