Cited by 292Telomeres, Telomerase, and SenescenceBladder and Urothelial Cancer TreatmentsCancer-related molecular mechanisms research

TERT promoter mutations and telomerase reactivation in urothelial cancer

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Borah, Sumit, Xi, Linghe, Zaug, Arthur J., Powell, Natasha M., Dancik, Garrett M., Cohen, Scott B., Costello, James C., Theodorescu, Dan +1 more·2015·Science

Abstract

The downstream effects of false promotion: Special DNA sequences at the ends of chromosomes, called telomeres, are replenished by a dedicated enzyme called telomerase. A subset of human tumors harbors mutations in the promoter region of the TERT gene, which codes for a subunit of telomerase. Borah et al. explored the downstream effects of TERT promoter mutations in cells derived from urothelial (urinary tract) cancers. The mutations were associated with aberrantly high levels of TERT mRNA, TERT protein and telomerase activity, and longer telomeres. A small study of clinical samples suggested that high levels of TERT mRNA may be a marker of more aggressive urothelial cancers. Science , this issue p. 1006

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  • In urothelial cancers, TERT promoter mutations correlate with higher TERT mRNA and protein levels, enzymatic activity, and greater telomere length.

    “An analysis of these mutations in urothelial cancers showed that they are correlated with higher levels of TERT mRNA and protein levels and enzymatic activity and with greater telomere length159.”

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  1. [2]Gunes C Lichtsteiner S Vasserot AP Englert C Cancer Res 60 2116 2121 2000 10786671
  2. [17]Lin Y Clin Cancer Res 2 929 932 1996 9816252
  3. [21]Kjeldsen E Tordrup D Hubner GM Knudsen BR Andersen FF Anticancer Res 30 3257 3265 2010 20944095
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Authors
Borah, S., Xi, L., Zaug, A. J., Powell, N. M., Dancik, G. M., Cohen, S. B., Costello, J. C., Theodorescu, D., & Cech, T. R.
Affiliations
  • Howard Hughes Medical Institute (US)
  • Eastern Connecticut State University (US)
  • The University of Sydney (AU)
  • University of Colorado Cancer Center (US)
Corresponding author
  • Borah, Sumit
  • Xi, Linghe
  • Zaug, Arthur J.
  • Cech, Thomas R.
Venue
Science
Published
2015-02-27
Volume
347
Issue
6225
Pages
1006-1010
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1975905059
Cited by
292
References
38
Citations by year
2026: 4 · 2025: 19 · 2024: 21 · 2023: 18 · 2022: 19 · 2021: 26 · 2020: 27 · 2019: 24 · 2018: 30 · 2017: 38 · 2016: 46 · 2015: 20
FWCI
32.92
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIH (CA075115, CA104106, R01 GM099705, T32 GM08759)
  • Howard Hughes Medical Institute
  • Cancer Council NSW
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Health Sciences › Medicine › Surgery › Bladder and Urothelial Cancer Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords
TERT promoter mutation, telomerase reactivation, urothelial carcinoma, telomerase reverse transcriptase, telomere length, disease-specific survival, prognostic factors, cancer cell immortality
MeSH terms
Urinary Bladder Neoplasms, Enzyme Activation, Humans, Promoter Regions, Genetic, RNA, Messenger, Biomarkers, Tumor, Point Mutation, Telomerase, Urothelium, Cell Line, Tumor, Telomere Homeostasis

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