TERT promoter mutations and telomerase reactivation in urothelial cancer
Open accessAbstract
The downstream effects of false promotion: Special DNA sequences at the ends of chromosomes, called telomeres, are replenished by a dedicated enzyme called telomerase. A subset of human tumors harbors mutations in the promoter region of the TERT gene, which codes for a subunit of telomerase. Borah et al. explored the downstream effects of TERT promoter mutations in cells derived from urothelial (urinary tract) cancers. The mutations were associated with aberrantly high levels of TERT mRNA, TERT protein and telomerase activity, and longer telomeres. A small study of clinical samples suggested that high levels of TERT mRNA may be a marker of more aggressive urothelial cancers. Science , this issue p. 1006
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In urothelial cancers, TERT promoter mutations correlate with higher TERT mRNA and protein levels, enzymatic activity, and greater telomere length.
“An analysis of these mutations in urothelial cancers showed that they are correlated with higher levels of TERT mRNA and protein levels and enzymatic activity and with greater telomere length159.”
From Telomeres in cancer: tumour suppression and genome instability (2017) · cites this paper as [159]
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- Authors
- Borah, S., Xi, L., Zaug, A. J., Powell, N. M., Dancik, G. M., Cohen, S. B., Costello, J. C., Theodorescu, D., & Cech, T. R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Eastern Connecticut State University (US)
- The University of Sydney (AU)
- University of Colorado Cancer Center (US)
- Corresponding author
- Borah, Sumit
- Xi, Linghe
- Zaug, Arthur J.
- Cech, Thomas R.
- ORCID
- Venue
- Science
- Published
- 2015-02-27
- Volume
- 347
- Issue
- 6225
- Pages
- 1006-1010
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4640672
- OpenAlex
- W1975905059
- Cited by
- 292
- References
- 38
- Citations by year
- 2026: 4 · 2025: 19 · 2024: 21 · 2023: 18 · 2022: 19 · 2021: 26 · 2020: 27 · 2019: 24 · 2018: 30 · 2017: 38 · 2016: 46 · 2015: 20
- FWCI
- 32.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (CA075115, CA104106, R01 GM099705, T32 GM08759)
- Howard Hughes Medical Institute
- Cancer Council NSW
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Surgery › Bladder and Urothelial Cancer Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- TERT promoter mutation, telomerase reactivation, urothelial carcinoma, telomerase reverse transcriptase, telomere length, disease-specific survival, prognostic factors, cancer cell immortality
- MeSH terms
- Urinary Bladder Neoplasms, Enzyme Activation, Humans, Promoter Regions, Genetic, RNA, Messenger, Biomarkers, Tumor, Point Mutation, Telomerase, Urothelium, Cell Line, Tumor, Telomere Homeostasis
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