The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System
Abstract
The mechanism of tumor necrosis factor (TNF)-α signaling is unknown. TNF-α signaling may involve sphingomyelin hydrolysis to ceramide by a sphingomyelinase and stimulation of a ceramide-activated protein kinase. In a cell-free system, TNF-α induced a rapid reduction in membrane sphingomyelin content and a quantitative elevation in ceramide concentrations. Ceramide-activated protein kinase activity also increased. Kinase activation was mimicked by addition of sphingomyelinase but not by phospholipases A 2 , C, or D. Reconstitution of this cascade in a cell-free system demonstrates tight coupling to the receptor, suggesting this is a signal transduction pathway for TNF-α.
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Cites
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An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control
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Cited by
The stress-activated protein kinase subfamily of c-Jun kinases
Kyriakis, J. M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruch, J., & Woodgett, J. R. (1994) · Nature · doi:10.1038/369156a0 · Cited by 2,596
Tumor necrosis factor signaling
Wajant, H., Pfizenmaier, K., & Scheurich, P. (2003) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401189 · Cited by 2,359
Jung, U., & Choi, M.-S. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15046184 · Cited by 1,880
Functions of Ceramide in Coordinating Cellular Responses to Stress
Hannun, Y. A. (1996) · Science · doi:10.1126/science.274.5294.1855 · Cited by 1,617
The sphingomyelin cycle and the second messenger function of ceramide.
Hannun, Y. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41834-5 · Cited by 1,235
Metadata
- Authors
- Dressler, K. A., Mathias, S., & Kolesnick, R. N.
- Venue
- Science
- Published
- 1992-03-27
- Volume
- 255
- Issue
- 5052
- Pages
- 1715-1718
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2091536410
- Cited by
- 440
- References
- 36
- FWCI
- 15.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dressler, K. A., Mathias, S., & Kolesnick, R. N. (1992). Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System. Science. https://doi.org/10.1126/science.1313189
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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