The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Biosynthesis of Human Papillomavirus from a Continuous Cell Line Upon Epithelial Differentiation
Abstract
The study of the human pathogen papillomaviruses (HPVs) has been hampered by the inability to propagate the virus in tissue culture. The addition of 12- O -tetradecanoyl phorbol-13-acetate to the media of organotypic (raft) cultures increased expression of physiological markers of keratinocyte differentiation and concomitantly induced production of virions. Capsid production was detected in differentiated suprabasal cells. Virions approximately 54 nanometers in size were observed by electron microscopy in raft tissue cross sections in the suprabasal layers. Virions purified through isopycnic gradients were found to contain type 31b DNA and exhibited an icosahedral shape similar to that of papillomaviruses found in clinical samples.
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Citations
Cites
Human Epidermis Reconstructed by Culture: Is It “Normal”?
Asselineau, D., Bernard, B. A., Bailly, C., Darmon, M., & Pruniéras, M. (1986) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12284237 · Cited by 192
Cited by
Human papillomavirus and cervical cancer
Burd, E. M. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.1.1-17.2003 · Cited by 2,420
Condom Use and the Risk of Genital Human Papillomavirus Infection in Young Women
Winer, R. L., Hughes, J. P., Feng, Q., O'Reilly, S., Kiviat, N. B., Holmes, K. K., & Koutsky, L. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa053284 · Cited by 694
Pathogenesis of Human Papillomaviruses in Differentiating Epithelia
Longworth, M. S., & Laimins, L. A. (2004) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.68.2.362-372.2004 · Cited by 677
Self-citationEstablishment of human papillomavirus infection requires cell cycle progression
Pyeon, D., Pearce, S. M., Lank, S. M., Ahlquist, P., & Lambert, P. F. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000318 · Cited by 348
Current understanding of the mechanism of HPV infection
Schiller, J. T., Day, P. M., & Kines, R. C. (2010) · Gynecologic Oncology · doi:10.1016/j.ygyno.2010.04.004 · Cited by 332
Metadata
- Authors
- Meyers, C., Frattini, M. G., Hudson, J. B., & Laimins, L. A.
- Venue
- Science
- Published
- 1992-08-14
- Volume
- 257
- Issue
- 5072
- Pages
- 971-973
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2011365922
- Cited by
- 455
- References
- 1
- FWCI
- 18.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Meyers, C., Frattini, M. G., Hudson, J. B., & Laimins, L. A. (1992). Biosynthesis of Human Papillomavirus from a Continuous Cell Line Upon Epithelial Differentiation. Science. https://doi.org/10.1126/science.1323879
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
