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Transcription Factor Loading on the MMTV Promoter: A Bimodal Mechanism for Promoter Activation
Abstract
The mouse mammary tumor virus (MMTV) promoter attains a phased array of six nucleosomes when introduced into rodent cells. This architecture excludes nuclear factor 1/CCAAT transcription factor (NF1/CTF) from the promoter before glucocorticoid treatment and hormone-dependent access of nucleolytic agents to promoter DNA. In contrast, when the promoter was transiently introduced into cells, NF1/CTF was bound constitutively and nucleolytic attack was hormone-independent. Thus, induction at this promoter was a bimodal process involving receptor-dependent remodeling of chromatin that allows NF1/CTF loading and direct receptor-mediated recruitment of additional transcription factors.
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Cited by
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Gu, W., & Roeder, R. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80521-8 · Cited by 2,559
The Aryl Hydrocarbon Receptor Complex
Hankinson, O. (1995) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.001515 · Cited by 1,649
The glucocorticoid receptor: rapid exchange with regulatory sites in living cells
McNally, J. G., Müller, W. G., Walker, D., Wolford, R., & Hager, G. L. (2000) · Science · doi:10.1126/science.287.5456.1262 · Cited by 802
Histone Deacetylases and SAP18, a Novel Polypeptide, Are Components of a Human Sin3 Complex
Zhang, Y., Iratni, R., Erdjument-Bromage, H., Tempst, P., & Reinberg, D. (1997) · Cell · doi:10.1016/s0092-8674(00)80216-0 · Cited by 578
Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex
Fryer, C. J., & Archer, T. K. (1998) · Nature · doi:10.1038/30032 · Cited by 511
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Metadata
- Authors
- Archer, T. K., Lefebvre, P., Wolford, R. G., & Hager, G. L.
- Venue
- Science
- Published
- 1992-03-20
- Volume
- 255
- Issue
- 5051
- Pages
- 1573-1576
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2043888927
- Cited by
- 392
- References
- 0
- FWCI
- 10.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Archer, T. K., Lefebvre, P., Wolford, R. G., & Hager, G. L. (1992). Transcription Factor Loading on the MMTV Promoter: A Bimodal Mechanism for Promoter Activation. Science. https://doi.org/10.1126/science.1347958
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
