The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Insulin Secretion from Pancreatic B Cells Caused by L-Arginine-Derived Nitrogen Oxides
Abstract
L-Arginine causes insulin release from pancreatic B cells. Data from three model systems support the hypothesis that L-arginine-derived nitrogen oxides (NOs) mediate insulin release stimulated by L-arginine in the presence of D-glucose and by the hypoglycemic drug tolbutamide. The formation of NO in pancreatic B cells was detected both chemically and by the NO-induced accumulation of guanosine 3′,5′-monophosphate. N G -substituted L-arginine analogs inhibited the release of both insulin and NO. Protein immunoblot and histochemical analysis with antiserum to type I NO synthase suggest that the formation of NO in pancreatic B cells is catalyzed by an NADPH- (reduced form of nicotinamide adenine dinucleotide phosphate), Ca 2+ /calmodulin-dependent type I NO synthase of about 150 kilodaltons.
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Citations
Cites
Stimulation of insulin secretion by amino acids.
Floyd, J. C., Fajans, S. S., Conn, J. W., Knopf, R. F., & Rull, J. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105456 · Cited by 727
Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus
Ward, W. K., Bolgiano, D. C., McKnight, B., Halter, J. B., & Porte, D. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111542 · Cited by 483
Cited by
Nitric oxide as a secretory product of mammalian cells
Nathan, C. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.12.1381691 · Cited by 4,350
The nitric oxide and cGMP signal transduction system: regulation and mechanism of action
Schmidt, H. H. H. W., Lohmann, S. M., & Walter, U. (1993) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(93)90006-b · Cited by 746
Self-citationCloned human brain nitric oxide synthase is highly expressed in skeletal muscle
Nakane, M., Schmidt, H. H. H. W., Pollock, J. S., Förstermann, U., & Murad, F. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81210-q · Cited by 546
Self-citationReduction in Pancreatic Transcription Factor PDX-1 Impairs Glucose-stimulated Insulin Secretion
Brissova, M., Shiota, M., Nicholson, W. E., Gannon, M., Knobel, S. M., Piston, D. W., Wright, C. V. E., & Powers, A. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111272200 · Cited by 375
Pieper, G. M. (1998) · Hypertension · doi:10.1161/01.hyp.31.5.1047 · Cited by 355
Metadata
- Authors
- Schmidt, H. H. H. W., Warner, T. D., Ishii, K., Sheng, H., & Murad, F.
- Venue
- Science
- Published
- 1992-02-07
- Volume
- 255
- Issue
- 5045
- Pages
- 721-723
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2066108840
- Cited by
- 420
- References
- 2
- FWCI
- 53.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Insulin Secretion from Pancreatic B Cells Caused by L-Arginine-Derived Nitrogen Oxides. https://app.cochat.ai/papers/10.1126/science.1371193
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- Schmidt, H. H. H. W., Warner, T. D., Ishii, K., Sheng, H., & Murad, F. (1992). Insulin Secretion from Pancreatic B Cells Caused by L-Arginine-Derived Nitrogen Oxides. Science. https://doi.org/10.1126/science.1371193
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