The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hyperalgesia Mediated by Spinal Glutamate or Substance P Receptor Blocked by Spinal Cyclooxygenase Inhibition
Abstract
Inhibition of cyclooxygenase by nonsteroidal anti-inflammatory drugs (NSAIDs) in the periphery is commonly accepted as the primary mechanism by which these agents produce a selective attenuation of pain (analgesia). NSAIDs are now shown to exert a direct spinal action by blocking the excessive sensitivity to pain (hyperalgesia) induced by the activation of spinal glutamate and substance P receptors. These findings demonstrate that the analgesic effects of NSAIDs can be dissociated from their anti-inflammatory actions. Spinal prostanoids are thus critical for the augmented processing of pain information at the spinal level.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
MacDermott, A. B., Mayer, M. L., Westbrook, G. L., Smith, S. J., & Barker, J. L. (1986) · Nature · doi:10.1038/321519a0 · Cited by 1,835
Cited by
Molecular mechanisms of nociception
Julius, D., & Basbaum, A. I. (2001) · Nature · doi:10.1038/35093019 · Cited by 2,685
The induction of pain: an integrative review
Millan, M. J. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00048-3 · Cited by 1,774
Amanzio, M., & Benedetti, F. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00484.1999 · Cited by 899
Altered pain perception and inflammatory response in mice lacking prostacyclin receptor
Murata, T., Ushikubi, F., Matsuoka, T., Hirata, M., Yamasaki, A., Sugimoto, Y., Ichikawa, A., Aze, Y., Tanaka, T., Yoshida, N., et al. (1997) · Nature · doi:10.1038/41780 · Cited by 773
Elevated cerebrospinal fluid levels of substance p in patients with the fibromyalgia syndrome
Russell, I. J., Orr, M. D., Littman, B., Vipraio, G. A., Alboukrek, D., Michalek, J. E., Lopez, Y., & Mackillip, F. (1994) · Arthritis & Rheumatism · doi:10.1002/art.1780371106 · Cited by 679
Graham, G. G., Davies, M. J., Day, R. O., Mohamudally, A., & Scott, K. F. (2013) · Inflammopharmacology · doi:10.1007/s10787-013-0172-x · Cited by 671
Cytokine-to-brain communication: A review & analysis of alternative mechanisms
Watkins, L. R., Maier, S. F., & Goehler, L. E. (1995) · Life Sciences · doi:10.1016/0024-3205(95)02047-m · Cited by 597
Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype
Reinold, H., Ahmadi, S., Depner, U. B., Layh, B., Heindl, C., Hamza, M., Pahl, A., Brune, K., Narumiya, S., Müller, U., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23618 · Cited by 202
Selective activation of microglia facilitates synaptic strength
Clark, A. K., Gruber-Schoffnegger, D., Drdla-Schutting, R., Gerhold, K. J., Malcangio, M., & Sandkühler, J. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2061-14.2015 · Cited by 171
The impact of opioid-induced hyperalgesia for postoperative pain
Koppert, W., & Schmelz, M. (2007) · Best Practice & Research Clinical Anaesthesiology · doi:10.1016/j.bpa.2006.12.004 · Cited by 154
Acetaminophen Inhibits Spinal Prostaglandin E2Release after Peripheral Noxious Stimulation
Muth-Selbach, U. S., Tegeder, I., Brune, K., & Geisslinger, G. (1999) · Anesthesiology · doi:10.1097/00000542-199907000-00032 · Cited by 142
Phenacetin, acetaminophen and dipyrone: analgesic and rewarding effects
Abbott, F. V., & Hellemans, K. G. C. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00179-0 · Cited by 72
Malmberg, A. B., & Yaksh, T. L. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90786-2 · Cited by 55
Self-citationEffect of Aspirin and Acetaminophen on Proinflammatory Cytokine-Induced Pain Behavior in Mice
Kwon, M.-S., Shim, E.-J., Seo, Y.-J., Choi, S.-S., Lee, J.-Y., Lee, H.-K., & Suh, H.-W. (2005) · Pharmacology · doi:10.1159/000084548 · Cited by 31
Non-steroidal Anti-inflammatory Drugs and Pain
Appleton, I. (1997) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-60777-6_3 · Cited by 11
Metadata
- Authors
- Malmberg, A. B., & Yaksh, T. L.
- Venue
- Science
- Published
- 1992-08-28
- Volume
- 257
- Issue
- 5074
- Pages
- 1276-1279
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2052840755
- Cited by
- 710
- References
- 1
- FWCI
- 23.15
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
