The DOI matches its Crossref record.
Intracranial Self-Stimulation in Man
Abstract
Intracranial self-stimulation techniques, modified for use with neuropsychiatric patients, provide data suggestive of positive and negative reinforcing properties of brief electrical stimulation to various subcortical structures of the human brain.
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“other studies indicating that the LS is part of the brain reward system.”
From Involvement of dopamine, but not norepinephrine, in the sex-specific regulation of juvenile socially rewarding behavior by vasopressin (2018) · cites this paper as [35]
In the citing paper
“the LS is associated with electrical self-stimulation in rats and humans [34,35]”
From Involvement of dopamine, but not norepinephrine, in the sex-specific regulation of juvenile socially rewarding behavior by vasopressin (2018) · cites this paper as [35]
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Research works printed but not linked: 15
- BECKER, H.C., A ROENTGENOGRAPHIC STEREOTAXIC TECHNIQUE FOR IMPLANTING AND MAINTAINING ELECTRODES IN THE BRAIN OF MAN, ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY 9: 533 (1957). · DOI
- Brady, J. V., Electrical Stimulation of the Brain: 425 (1961).
- Delgado, J. M. R., Electrical Studies on the Unanesthetized Brain: 144 (1960).
- HEATH, R.G., COMMON CHARACTERISTICS OF EPILEPSY AND SCHIZOPHRENIA - CLINICAL OBSERVATION AND DEPTH ELECTRODE STUDIES, AMERICAN JOURNAL OF PSYCHIATRY 118: 1013 (1962). · DOI
- Heath, R. G., Electrical Studies on the Unanesthetized Brain: 214 (1960).
- Heath, R. G., Psychosomatic Medicine: 228 (1962).
- Heath, R. G., Studies In Schizophrenia: 46 (1954).
- Heath, R. G., Studies In Schizophrenia: 348 (1954).
- HIGGINS, J.W., BEHAVIORAL CHANGES DURING INTRACEREBRAL ELECTRICAL STIMULATION, ARCHIVES OF NEUROLOGY AND PSYCHIATRY 76: 399 (1956). · DOI
- Olds, J., Electrical Stimulation of the Brain: 425 (1961).
- OLDS, J, POSITIVE REINFORCEMENT PRODUCED BY ELECTRICAL STIMULATION OF SEPTAL AREA AND OTHER REGIONS OF RAT BRAIN, JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY 47: 419 (1954). · DOI · Paper page
- OLDS, J, EFFECTS OF HUNGER AND MALE SEX HORMONE ON SELF-STIMULATION OF THE BRAIN, JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY 51: 320 (1958). · DOI
- OLDS, J, HYPOTHALAMIC SUBSTRATES OF REWARD, PHYSIOLOGICAL REVIEWS 42: 554 (1962). · DOI
- Sem-Jacobsen, C. W., Electrical Studies on the Unanesthetized Brain: 280 (1960).
- Sem-Jacobsen, C. W., Electroencephalography and Clinical Neurophysiology 11: 379 (1959).
Cited by
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Items 101–117 of 117
HIT and brain reward function: A case of mistaken identity (theory).
Wright, C., Colombo, M., & Beard, A. (2017) · Studies in history and philosophy of biological and biomedical sciences · doi:10.1016/j.shpsc.2017.04.002 · Cited by 1
“The trouble is that the statements were asserted, or even inventeddnot7 See, e.g., Sem-Jacobsen (1959); Delgado & Hamlin (1960); Bishop et al. (1963); Heath (1963); Heath & Gallant (1964). by Kanwisher and her colleaguesdbut by advocates of HIT themselves.8 For their part, the scientists neither…”
BackgroundTreatment-Resistant Depression: Deep Brain Stimulation
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Ressourcenaktivierung und Beziehungsgestaltung: Bedürfnisbefriedigung in der Psychotherapie
Flückiger, C., & Holtforth, M. G. (2017) · Springer eBooks · doi:10.1007/978-3-662-53471-7_3 · Cited by 1
Functional Surgery: From Lesioning to Deep Brain Stimulation and Beyond
Sankar, T., & Lozano, A. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-397025-1.00118-4 · Cited by 1
Dopamine signaling in the medial accumbens shell constrains the duration of reinforced actions.
Valyear, M. D., Eustachon, N. M.-L., Morris, M. M., Alymova, I., Tremblay, B. N., Mitrikeski, N. M., & Britt, J. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.118140
A disengaging property of dopamine signalingPreprint
Valyear, M. D., Eustachon, N. M.-L., Morris, M. M., Alymova, I., Tremblay, B. N., Mitrikeski, N. M., & Britt, J. (2026) · bioRxiv · doi:10.1101/2023.11.29.569116
Optogenetics and Controlling the Human Mind
Guynn, M. (2021) · Curiosity: Interdisciplinary Journal of Research and Innovation · doi:10.36898/001c.28096
“Although the experiment was highly invasive there is no mention in the paper of informed consent (Bishop et al., 1963).”
BackgroundGardner, E. L. (2020) · Springer eBooks · doi:10.1007/978-3-030-36391-8_4 · Cited by 7
Affective percept and voluntary action: a hypothesis.
Żernicki, B. (2002) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2002-1426
Rylov, A., & Kalyuzhnyi, L. (1981) · Bulletin of experimental biology and medicine · doi:10.1007/bf00827462
Flückiger, C., & Holtforth, M. G. (2022) · Therapieziel Wohlbefinden · doi:10.1007/978-3-662-63821-7_9
Bogerts, B. (2021) · Woher kommt Gewalt? · doi:10.1007/978-3-662-63338-0_6
Reward deficits in compulsive eating
Kenny, P. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816207-1.00005-6
The Roots and Individual Diversity of Addiction
Leis, A. B. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-420190-3.00031-4
Compulsive Drug Use and Brain Reward Systems
Hollander, J. A., & Kenny, P. J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3375-0_5
Metadata
- Authors
- Bishop, M. P., Elder, S. T., & Heath, R. G.
- Affiliations
- Tulane University (US)
- Venue
- Science
- Published
- 1963-04-26
- Volume
- 140
- Issue
- 3565
- Pages
- 394-396
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012590570
- Cited by
- 142
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 7 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 8 · 2014: 8 · 2013: 6 · 2012: 5
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- intracranial self-stimulation, electrical brain stimulation, reinforcement, positive reinforcement, negative reinforcement, subcortical structures, neuropsychiatric patients, human brain
- MeSH terms
- Brain, Electric Stimulation, Electrophysiology, Reinforcement, Psychology, Self Stimulation
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