The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Excess Lactate: An Index of Reversibility of Shock in Human Patients
Abstract
"Excess lactate," an indicator of oxygen debt, has been studied as a metabolic index of severity of the shock state in human patients. The levels of excess lactate correspond to severity of circulatory failure, and an excess of more than 4 millimoles per liter prognosticates a fatal outcome. The validity of this index was confirmed by studies on experimental hemorrhagic shock in dogs. It provides a parameter for measurement of "reversibility" and serves as an objective clinical guide.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
THE COLORIMETRIC DETERMINATION OF LACTIC ACID IN BIOLOGICAL MATERIAL
Barker, S. B., & Summerson, W. H. (1941) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51379-x · Cited by 3,431
Friedemann, T. E., & Haugen, G. E. (1943) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)72397-1 · Cited by 1,916
Huckabee, W. E. (1958) · Journal of Clinical Investigation · doi:10.1172/jci103603 · Cited by 669
Huckabee, W. E. (1958) · Journal of Clinical Investigation · doi:10.1172/jci103604 · Cited by 242
Abnormal resting blood lactate
Huckabee, W. E. (1961) · The American Journal of Medicine · doi:10.1016/0002-9343(61)90172-3 · Cited by 216
Oxygen debt, lactate, pyruvate, and excess lactate after muscular work
Knuttgen, H. G. (1962) · Journal of Applied Physiology · doi:10.1152/jappl.1962.17.4.639 · Cited by 73
TRAUMATIC SHOCK. XV. CARBOHYDRATE METABOLISM IN HEMORRHAGIC SHOCK IN THE DOG 1
Seligman, A. M., Frank, H. A., Alexander, B., & Fine, J. (1947) · Journal of Clinical Investigation · doi:10.1172/jci101838 · Cited by 35
Cited by
Management of bleeding following major trauma: an updated European guideline
Rossaint, R., Bouillon, B., Cerny, V., Coats, T. J., Duranteau, J., Fernández-Mondéjar, E., Hunt, B. J., Komadina, R., Nardi, G., Neugebauer, E., et al. (2010) · Critical Care · doi:10.1186/cc8943 · Cited by 818
Etiology and Therapeutic Approach to Elevated Lactate Levels
Andersen, L. W., Mackenhauer, J., Roberts, J. C., Berg, K. M., Cocchi, M. N., & Donnino, M. W. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.06.012 · Cited by 731
WEIL, M. H., & AFIFI, A. A. (1970) · Circulation · doi:10.1161/01.cir.41.6.989 · Cited by 709
Self-citationCasserly, B., Phillips, G. S., Schorr, C., Dellinger, R. P., Townsend, S. R., Osborn, T. M., Reinhart, K., Selvakumar, N., & Levy, M. M. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000000742 · Cited by 465
Management of bleeding following major trauma: a European guideline
Spahn, D. R., Cerny, V., Coats, T. J., Duranteau, J., Fernández-Mondéjar, E., Gordini, G., Stahel, P. F., Hunt, B. J., Komadina, R., Neugebauer, E., et al. (2007) · Critical Care · doi:10.1186/cc5686 · Cited by 437
Metadata
- Authors
- Broder, G., & Weil, M. H.
- Venue
- Science
- Published
- 1964-03-27
- Volume
- 143
- Issue
- 3613
- Pages
- 1457-1459
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2024702334
- Cited by
- 521
- References
- 7
- FWCI
- 17.27
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Excess Lactate: An Index of Reversibility of Shock in Human Patients. https://app.cochat.ai/papers/10.1126/science.143.3613.1457
- The paper
- Broder, G., & Weil, M. H. (1964). Excess Lactate: An Index of Reversibility of Shock in Human Patients. Science. https://doi.org/10.1126/science.143.3613.1457
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.