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Hydroxylation of Proline and the Intracellular Accumulation of a Polypeptide Precursor of Collagen
Abstract
Autoradiographs of embryonic cartilage indicated that labeled protein accumulated intracellularly when the tissue was incubated with tritiated proline, and when the hydroxylation of proline was inhibited by anaerobic conditions or by a chelator for ferrous iron. The labeled protein apparently corresponds to protocollagen, the polypeptide precursor of collagen which serves as a substrate for the enzymatic synthesis of hydroxyproline.
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Citations
Cited by
Metabolism of Proline and the Hydroxyprolines
Adams, E., & Frank, L. (1980) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.49.070180.005041 · Cited by 522
The Role of Oxygen in Wound Healing: A Review of the Literature
RODRIGUEZ, P. G., FELIX, F. N., WOODLEY, D. T., & SHIM, E. K. (2008) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2008.34254.x · Cited by 371
Synthesis and extrusion of collagen by freshly isolated cells from chick embryo tendon
Dehm, P., & Prockop, D. J. (1971) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(71)90529-6 · Cited by 279
Self-citationLaVan, F. B., & Hunt, T. K. (1990) · Clinics in Plastic Surgery · doi:10.1016/s0094-1298(20)30621-0 · Cited by 273
Oxygen-Collagen Priority and the Early Metazoan Fossil Record
Towe, K. M. (1970) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.65.4.781 · Cited by 180
Metadata
- Authors
- Juva, K., Prockop, D. J., Cooper, G. W., & Lash, J. W.
- Venue
- Science
- Published
- 1966-04
- Volume
- 152
- Issue
- 3718
- Pages
- 92-94
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2048321503
- Cited by
- 178
- References
- 0
- FWCI
- 16.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Juva, K., Prockop, D. J., Cooper, G. W., & Lash, J. W. (1966). Hydroxylation of Proline and the Intracellular Accumulation of a Polypeptide Precursor of Collagen. Science. https://doi.org/10.1126/science.152.3718.92
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.