The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
The Role of Oxygen in Wound Healing: A Review of the Literature
Abstract
BACKGROUND: The presence of oxygen is necessary for normal wound healing. Oxygen has been given as a therapeutic modality to assist and speed wound healing. OBJECTIVE: The objective was to summarize the role of oxygen in wound healing. MATERIALS AND METHODS: A literature review of clinical and basic science studies regarding oxygen and wound healing was conducted. RESULTS: Hypoxia appears to jump start wound healing via hypoxia-inducible factor 1alpha and reepithelialization. Nonetheless, oxygen is often required to start or sustain other wound healing processes. CONCLUSION: Both the absence and the presence of oxygen have effects on wound healing; however, its role is not completely understood. Although hyperbaric oxygen and topical oxygen therapy have been described in aiding wound healing, case-controlled prospective studies are lacking and evidence for their efficacy is inconsistent. The authors have indicated no significant interest with commercial supporters.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Singer, A. J., & Clark, R. A. F. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411006 · Cited by 6,106
Requirement for Generation of H 2 O 2 for Platelet-Derived Growth Factor Signal Transduction
Sundaresan, M., Yu, Z.-X., Ferrans, V. J., Irani, K., & Finkel, T. (1995) · Science · doi:10.1126/science.270.5234.296 · Cited by 2,520
WINTER, G. D. (1962) · Nature · doi:10.1038/193293a0 · Cited by 2,253
Supplemental Perioperative Oxygen to Reduce the Incidence of Surgical-Wound Infection
Greif, R., Akça, O., Horn, E.-P., Kurz, A., & Sessler, D. I. (2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420303 · Cited by 1,159
Møller, A. M., Villebro, N., Pedersen, T., & Tønnesen, H. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07369-5 · Cited by 1,126
The Biosynthesis of Collagen and Its Disorders
Prockop, D. J., Kivirikko, K. I., Tuderman, L., & Guzman, N. A. (1979) · New England Journal of Medicine · doi:10.1056/nejm197907053010104 · Cited by 1,064
HIF-1 and human disease: one highly involved factor
Semenza, G. L. (2000) · Genes & Development · doi:10.1101/gad.14.16.1983 · Cited by 909
Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes
Gerber, H.-P., Condorelli, F., Park, J., & Ferrara, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23659 · Cited by 794
Oxygen Tension Regulates the Expression of Angiogenesis Factor by Macrophages
Knighton, D. R., Hunt, T. K., Scheuenstuhl, H., Halliday, B. J., Werb, Z., & Banda, M. J. (1983) · Science · doi:10.1126/science.6612342 · Cited by 685
Silverstein, P. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90623-j · Cited by 641
Cited by
Factors affecting wound healing
Guo, S., & DiPietro, L. A. (2010) · Journal of Dental Research · doi:10.1177/0022034509359125 · Cited by 5,792
Dunnill, C., Patton, T., Brennan, J., Barrett, J., Dryden, M., Cooke, J., Leaper, D., & Georgopoulos, N. T. (2017) · International Wound Journal · doi:10.1111/iwj.12557 · Cited by 1,380
The Role of Hypoxia-Inducible Factor in Wound Healing
Hong, W. X., Hu, M. S., Esquivel, M., Liang, G. Y., Rennert, R. C., McArdle, A., Paik, K. J., Duscher, D., Gurtner, G. C., Lorenz, H. P., et al. (2014) · Advances in Wound Care · doi:10.1089/wound.2013.0520 · Cited by 448
Shiekh, P. A., Singh, A., & Kumar, A. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120020 · Cited by 443
The Role of Antioxidants on Wound Healing: A Review of the Current Evidence
Comino-Sanz, I. M., López-Franco, M. D., Castro, B., & Pancorbo-Hidalgo, P. L. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10163558 · Cited by 412
Metadata
- Authors
- RODRIGUEZ, P. G., FELIX, F. N., WOODLEY, D. T., & SHIM, E. K.
- Venue
- Dermatologic Surgery
- Published
- 2008-09
- Volume
- 34
- Issue
- 9
- Pages
- 1159-1169
- ISSN
- 1076-0512 (ISSN-L)
- 1524-4725
- OpenAlex
- W2116435307
- Cited by
- 371
- References
- 93
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Role of Oxygen in Wound Healing: A Review of the Literature. https://app.cochat.ai/papers/10.1111/j.1524-4725.2008.34254.x
- The paper
- RODRIGUEZ, P. G., FELIX, F. N., WOODLEY, D. T., & SHIM, E. K. (2008). The Role of Oxygen in Wound Healing: A Review of the Literature. Dermatologic Surgery. https://doi.org/10.1111/j.1524-4725.2008.34254.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
