The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Identification of ras Oncogene Mutations in the Stool of Patients with Curable Colorectal Tumors
Abstract
Colorectal (CR) tumors are usually curable if detected before metastasis. Because genetic alterations are associated with the development of these tumors, mutant genes may be found in the stool of individuals with CR neoplasms. The stools of nine patients whose tumors contained mutations of K- ras were analyzed. In eight of the nine cases, the ras mutations were detectable in DNA purified from the stool. These patients included those with benign and malignant neoplasms from proximal and distal colonic epithelium. Thus, colorectal tumors can be detected by a noninvasive method based on the molecular pathogenesis of the disease.
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Citations
Cites
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Self-citationGenetic Alterations during Colorectal-Tumor Development
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Self-citationMutations in the p53 gene occur in diverse human tumour types
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Self-citationThe evolution of cancer of the colon and rectum
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Prevalence of ras gene mutations in human colorectal cancers
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Self-citationRapid transfer of DNA from agarose gels to nylon membranes
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Molecular themes in oncogenesis
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Self-citationScreening for Colorectal Cancer
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Cited by
Liquid biopsies come of age: Towards implementation of circulating tumour DNA
Wan, J. C. M., Massie, C., Garcia-Corbacho, J., Mouliere, F., Brenton, J. D., Caldas, C., Pacey, S., Baird, R., & Rosenfeld, N. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.7 · Cited by 2,809
APC mutations occur early during colorectal tumorigenesis
Powell, S. M., Zilz, N., Beazer-Barclay, Y., Bryan, T. M., Hamilton, S. R., Thibodeau, S. N., Vogelstein, B., & Kinzler, K. W. (1992) · Nature · doi:10.1038/359235a0 · Cited by 1,924
Self-citationMolecular Genetics of Colorectal Cancer
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Self-citationDetection and quantification of mutations in the plasma of patients with colorectal tumors
Diehl, F., Li, M., Dressman, D., He, Y., Shen, D., Szabo, S., Diaz, L. A., Goodman, S. N., David, K. A., Juhl, H., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507904102 · Cited by 1,188
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Metadata
- Authors
- Sidransky, D., Tokino, T., Hamilton, S. R., Kinzler, K. W., Levin, B., Frost, P., & Vogelstein, B.
- Venue
- Science
- Published
- 1992-04-03
- Volume
- 256
- Issue
- 5053
- Pages
- 102-105
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1995134833
- Cited by
- 698
- References
- 33
- FWCI
- 21.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sidransky, D., Tokino, T., Hamilton, S. R., Kinzler, K. W., Levin, B., Frost, P., & Vogelstein, B. (1992). Identification of ras Oncogene Mutations in the Stool of Patients with Curable Colorectal Tumors. Science. https://doi.org/10.1126/science.1566048
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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