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Cloning of the γ Chain of the Human IL-2 Receptor
Abstract
A third subunit, the γ chain, of the human interleukin-2 receptor (IL-2R) was identified, and a complementary DNA clone encoding this member of the cytokine receptor family was isolated. The γ chain is necessary for the formation of the high- and intermediate-affinity receptors, which consist of αβγ heterotrimers and βγ heterodimers, respectively. The IL-2R on murine fibroblastoid cells can be internalized after binding IL-2 only if the γ chain is present; α and β are insufficient for internalization. Thus, the γ chain is an indispensable component of the functional IL-2R.
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Cited by
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Miossec, P., Korn, T., & Kuchroo, V. K. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0707449 · Cited by 1,409
Howe, S. J., Mansour, M. R., Schwarzwaelder, K., Bartholomae, C., Hubank, M., Kempski, H., Brugman, M. H., Pike-Overzet, K., Chatters, S. J., de Ridder, D., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35798 · Cited by 1,286
Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β
Suzuki, H., Kündig, T. M., Furlonger, C., Wakeham, A., Timms, E., Matsuyama, T., Schmits, R., Simard, J. J. L., Ohashi, P. S., Griesser, H., et al. (1995) · Science · doi:10.1126/science.7770771 · Cited by 871
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Metadata
- Authors
- Takeshita, T., Asao, H., Ohtani, K., Ishii, N., Kumaki, S., Tanaka, N., Munakata, H., Nakamura, M., & Sugamura, K.
- Venue
- Science
- Published
- 1992-07-17
- Volume
- 257
- Issue
- 5068
- Pages
- 379-382
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2072252693
- Cited by
- 840
- References
- 0
- FWCI
- 43.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Takeshita, T., Asao, H., Ohtani, K., Ishii, N., Kumaki, S., Tanaka, N., Munakata, H., Nakamura, M., & Sugamura, K. (1992). Cloning of the γ Chain of the Human IL-2 Receptor. Science. https://doi.org/10.1126/science.1631559
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