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Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes
Abstract
Interleukin-2 (IL-2), which is a growth factor for T lymphocytes, can also sometimes be inhibitory. Thus, the proliferation of CD8 + T cells in vivo is increased after the injection of a monoclonal antibody that is specific for IL-2 (IL-2 mAb), perhaps reflecting the removal of IL-2–dependent CD4 + T regulatory cells (T regs). Instead, we show here that IL-2 mAb augments the proliferation of CD8 + cells in mice simply by increasing the biological activity of preexisting IL-2 through the formation of immune complexes. When coupled with recombinant IL-2, some IL-2/IL-2 mAb complexes cause massive (>100-fold) expansion of CD8 + cells in vivo, whereas others selectively stimulate CD4 + T regs. Thus, different cytokine-antibody complexes can be used to selectively boost or inhibit the immune response.
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Cited by
Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145
A Special Population of Regulatory T Cells Potentiates Muscle Repair
Burzyn, D., Kuswanto, W., Kolodin, D., Shadrach, J. L., Cerletti, M., Jang, Y., Sefik, E., Tan, T. G., Wagers, A. J., Benoist, C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.054 · Cited by 1,234
“For the gain-of-function experiments, we made use of the published observation that complexes of recombinant IL-2 and a particular anti-IL-2 mAb (clone JES6-1A12) can preferentially expand Treg populations after injection into mice (Boyman et al., 2006).”
Koch, M. A., Tucker-Heard, G., Perdue, N. R., Killebrew, J. R., Urdahl, K. B., & Campbell, D. J. (2009) · Nature Immunology · doi:10.1038/ni.1731 · Cited by 1,258
Homeostasis of Naive and Memory T Cells
Surh, C. D., & Sprent, J. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.002 · Cited by 1,193
Self-citationMalek, T. R. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090357 · Cited by 1,079
Metadata
- Authors
- Boyman, O., Kovar, M., Rubinstein, M. P., Surh, C. D., & Sprent, J.
- Venue
- Science
- Published
- 2006-03-31
- Volume
- 311
- Issue
- 5769
- Pages
- 1924-1927
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1996642272
- Cited by
- 870
- References
- 0
- FWCI
- 12.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Boyman, O., Kovar, M., Rubinstein, M. P., Surh, C. D., & Sprent, J. (2006). Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes. Science. https://doi.org/10.1126/science.1122927
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
