The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β
Abstract
In mice lacking the interleukin-2 receptor β chain (IL-2Rβ), T cells were shown to be spontaneously activated, resulting in exhaustive differentiation of B cells into plasma cells and the appearance of high serum concentrations of immunoglobulins G1 and E as well as autoantibodies that cause hemolytic anemia. Marked infiltrative granulocytopoiesis was also apparent, and the animals died after about 12 weeks. Depletion of CD4 + T cells in mutant mice rescued B cells without reversion of granulocyte abnormalities. T cells did not proliferate in response to polyclonal activators, nor could antigen-specific immune responses be elicited. Thus, IL-2Rβ is required to keep the activation programs of T cells under control, to maintain homeostasis, and to prevent autoimmunity.
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Cites
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Cited by
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Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice
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Metadata
- Authors
- Suzuki, H., Kündig, T. M., Furlonger, C., Wakeham, A., Timms, E., Matsuyama, T., Schmits, R., Simard, J. J. L., Ohashi, P. S., Griesser, H., Taniguchi, T., Paige, C. J., & Mak, T. W.
- Venue
- Science
- Published
- 1995-06-09
- Volume
- 268
- Issue
- 5216
- Pages
- 1472-1476
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2079721061
- Cited by
- 871
- References
- 25
- FWCI
- 14.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Suzuki, H., Kündig, T. M., Furlonger, C., Wakeham, A., Timms, E., Matsuyama, T., Schmits, R., Simard, J. J. L., Ohashi, P. S., Griesser, H., Taniguchi, T., Paige, C. J., & Mak, T. W. (1995). Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β. Science. https://doi.org/10.1126/science.7770771
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