The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Establishment of Stable, Cell-Mediated Immunity that Makes "Susceptible" Mice Resistant to Leishmania major
Abstract
Cell-mediated, but not antibody-mediated, immune responses protect humans against certain pathogens that produce chronic diseases such as leishmaniasis. Effective vaccination against such pathogens must therefore produce an immunological "imprint" so that stable, cell-mediated immunity is induced in all individuals after natural infection. BALB/c mice "innately susceptible" to Leishmania major produce antibodies after substantial infection. In the present study, "susceptible" mice injected with a small number of parasites mounted a cell-mediated response and acquired resistance to a larger, normally pathogenic, challenge. This vaccination strategy may be applicable in diseases in which protection is dependent on cell-mediated immunity.
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Cites
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Cited by
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Metadata
- Authors
- Bretscher, P. A., Wei, G., Menon, J. N., & Bielefeldt-Ohmann, H.
- Venue
- Science
- Published
- 1992-07-24
- Volume
- 257
- Issue
- 5069
- Pages
- 539-542
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2168416755
- Cited by
- 499
- References
- 14
- FWCI
- 40.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bretscher, P. A., Wei, G., Menon, J. N., & Bielefeldt-Ohmann, H. (1992). Establishment of Stable, Cell-Mediated Immunity that Makes "Susceptible" Mice Resistant to Leishmania major. Science. https://doi.org/10.1126/science.1636090
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
