The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production
Abstract
Gamma interferon (IFN-γ) and B cell stimulatory factor-1 (BSF-1), also known as interleukin-4, are T cell-derived lymphokines that have potent effects on B cell proliferation and differentiation. They are often secreted by distinct T cell clones. It is now shown that IFN-γ stimulates the expression of immunoglobulin (Ig) of the IgG2a isotype and inhibits the production of IgG3, IgG1, IgG2b, and IgE. By contrast, BSF-1 has powerful effects in promoting switching to the expression of IgG1 and IgE but markedly inhibits IgM, IgG3, IgG2a, and IgG2b. These results indicate that BSF-1 and IFN-γ as well as the T cells that produce them may act as reciprocal regulatory agents in the determination of Ig isotype responses. The effects of IFN-γ and BSF-1 on isotype expression are independent.
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Cites
Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,506
B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.
Coffman, R. L., Ohara, J., Bond, M. W., Carty, J., Zlotnik, A., & Paul, W. E. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.12.4538 · Cited by 796
Self-citationA T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma.
Coffman, R. L., & Carty, J. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.3.949 · Cited by 734
T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.
Isakson, P. C., Puré, E., Vitetta, E. S., & Krammer, P. H. (1982) · The Journal of experimental medicine · doi:10.1084/jem.155.3.734 · Cited by 442
IgG2a restriction of murine antibodies elicited by viral infections.
Coutelier, J. P., van der Logt, J. T., Heessen, F. W., Warnier, G., & Van Snick, J. (1987) · The Journal of experimental medicine · doi:10.1084/jem.165.1.64 · Cited by 428
T-cell and mast cell lines respond to B-cell stimulatory factor 1.
Mosmann, T. R., Bond, M. W., Coffman, R. L., Ohara, J., & Paul, W. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.15.5654 · Cited by 378
Self-citationMolecular structure of human lymphocyte receptor for immunoglobulin E
Kikutani, H., Inui, S., Sato, R., Barsumian, E. L., Owaki, H., Yamasaki, K., Kaisho, T., Uchibayashi, N., Hardy, R. R., Hirano, T., et al. (1986) · Cell · doi:10.1016/0092-8674(86)90508-8 · Cited by 357
Finkelman, F. D., Katona, I. M., Urban, J. F., Snapper, C. M., Ohara, J., & Paul, W. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9675 · Cited by 349
Self-citationImmune interferon induces the receptor for monomeric IgG1 on human monocytic and myeloid cells.
Perussia, B., Dayton, E. T., Lazarus, R., Fanning, V, & Trinchieri, G. (1983) · The Journal of experimental medicine · doi:10.1084/jem.158.4.1092 · Cited by 332
Schreiber, R. D., Hicks, L. J., Celada, A., Buchmeier, N. A., & Gray, P. W. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.134.3.1609 · Cited by 284
Cited by
Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692
Interferon-γ: an overview of signals, mechanisms and functions
Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120
HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932
CELLULAR RESPONSES TO INTERFERON-γ
Boehm, U., Klamp, T., Groot, M., & Howard, J. C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.749 · Cited by 2,890
Stein, M., Keshav, S., Harris, N., & Gordon, S. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.1.287 · Cited by 1,960
Metadata
- Authors
- Snapper, C. M., & Paul, W. E.
- Venue
- Science
- Published
- 1987-05-22
- Volume
- 236
- Issue
- 4804
- Pages
- 944-947
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2041647537
- Cited by
- 1,920
- References
- 20
- FWCI
- 28.00
- Type
- journal article
- Language
- en
- Open access
- closed
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