The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
CREB: a Ca 2+ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases
Abstract
The mechanism by which Ca 2+ mediates gene induction in response to membrane depolarization was investigated. The adenosine 3′,5′-monophosphate (cAMP) response element-binding protein (CREB) was shown to function as a Ca 2+ -regulated transcription factor and as a substrate for depolarization-activated Ca 2+ -calmodulin-dependent protein kinases (CaM kinases) I and II. CREB residue Ser 133 was the major site of phosphorylation by the CaM kinases in vitro and of phosphorylation after membrane depolarization in vivo. Mutation of Ser 133 impaired the ability of CREB to respond to Ca 2+ . These results suggest that CaM kinases may transduce electrical signals to the nucleus and that CREB functions to integrate Ca 2+ and cAMP signals.
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Citations
Cites
The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins
Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1988) · Science · doi:10.1126/science.3289117 · Cited by 3,443
Cited by
Function and regulation of CREB family transcription factors in the nervous system
Lonze, B. E., & Ginty, D. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00828-0 · Cited by 2,127
Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., & Greenberg, M. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81010-7 · Cited by 1,561
Self-citationSilva, A. J., Kogan, J. H., Frankland, P. W., & Kida, S. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.127 · Cited by 1,462
Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways
Bading, H., Ginty, D. D., & Greenberg, M. E. (1993) · Science · doi:10.1126/science.8097060 · Cited by 1,157
Self-citationBito, H., Deisseroth, K., & Tsien, R. W. (1996) · Cell · doi:10.1016/s0092-8674(00)81816-4 · Cited by 1,122
Metadata
- Authors
- Sheng, M., Thompson, M. A., & Greenberg, M. E.
- Venue
- Science
- Published
- 1991-06-07
- Volume
- 252
- Issue
- 5011
- Pages
- 1427-1430
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2081704409
- Cited by
- 1,488
- References
- 1
- FWCI
- 27.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sheng, M., Thompson, M. A., & Greenberg, M. E. (1991). CREB: a Ca 2+ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases. Science. https://doi.org/10.1126/science.1646483
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
