CREB AND MEMORY

Silva, Alcino J.; Kogan, Jeffrey H.; Frankland, Paul W.; Kida, Satoshi

doi:10.1146/annurev.neuro.21.1.127

Cited by 1,462Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurobiology and Insect Physiology Research

CREB AND MEMORY

Silva, Alcino J., Kogan, Jeffrey H., Frankland, Paul W., Kida, Satoshi·1998·Annual Review of Neuroscience

DOI 10.1146/annurev.neuro.21.1.127

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Abstract

▪ Abstract The cAMP responsive element binding protein (CREB) is a nuclear protein that modulates the transcription of genes with cAMP responsive elements in their promoters. Increases in the concentration of either calcium or cAMP can trigger the phosphorylation and activation of CREB. This transcription factor is a component of intracellular signaling events that regulate a wide range of biological functions, from spermatogenesis to circadian rhythms and memory. Here we review the key features of CREB-dependent transcription, as well as the involvement of CREB in memory formation. Evidence from Aplysia, Drosophila, mice, and rats shows that CREB-dependent transcription is required for the cellular events underlying long-term but not short-term memory. While the work in Aplysia and Drosophila only involved CREB function in very simple forms of conditioning, genetic and pharmacological studies in mice and rats demonstrate that CREB is required for a variety of complex forms of memory, including spatial and social learning, thus indicating that CREB may be a universal modulator of processes required for memory formation.

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Spaced training may be more effective, in part, because it may allow sufficient time for transcription factors such as CREB to be activated, bind to promoters and induce a round of transcription for consolidation of LTP or long-term facilitation.
“Spaced training may be more effective, in part, because it may allow sufficient time for transcription factors such as CREB to be activated, bind to promoters and induce a round of transcription for the consolidation of LTP53 or for long-term facilitation (LTF) of synapses54.”
From The right time to learn: Mechanisms and optimization of spaced learning (2016) · cites this paper as [53]
LTF and LTP both rely on cooperative gene induction by pCREB and CBP.
“and both rely on cooperative gene induction by pCREB and CBP53,96,99,100.”
From The right time to learn: Mechanisms and optimization of spaced learning (2016) · cites this paper as [53]

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Authors: Silva, A. J., Kogan, J. H., Frankland, P. W., & Kida, S.
Affiliations: Cold Spring Harbor Laboratory (US)
ORCID: Silva, Alcino J.
Frankland, Paul W.
Kida, Satoshi
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 1998-03
Volume: 21
Issue: 1
Pages: 127-148
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev.neuro.21.1.127
OpenAlex: W2133850147
Cited by: 1,462
References: 97
Citations by year: 2026: 18 · 2025: 36 · 2024: 36 · 2023: 30 · 2022: 40 · 2021: 34 · 2020: 43 · 2019: 50 · 2018: 42 · 2017: 53 · 2016: 65 · 2015: 54 · 2014: 64 · 2013: 56 · 2012: 73
FWCI: 6.57
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: CREB, cAMP-responsive element-binding protein, memory formation, long-term memory, CREB-dependent transcription, cAMP signaling, calcium signaling, transcription factor phosphorylation, spatial learning, social learning, Aplysia, Drosophila, mice, rats
MeSH terms: Animals, Memory, Cyclic AMP Response Element-Binding Protein

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