The DOI matches its Crossref record.
Variable Effects of Phosphorylation of Pit-1 Dictated by the DNA Response Elements
Abstract
Pit-1, a tissue-specific POU domain transcription factor, is required for the activation of the prolactin, growth hormone, and Pit-1 promoters that confer regulation by epidermal growth factor, adenosine 3′,5′-monophosphate (cAMP), and phorbol esters. Pit-1 is phosphorylated in pituitary cells at two distinct sites in response to phorbol esters and cAMP. Phosphorylation of Pit-1 modifies its conformation on DNA recognition elements and results in increased binding at certain sites and decreased binding at other sites, dependent on DNA sequences adjacent to the core Pit-1 binding motif. One residue (Thr 220 ), located in the POU homeodomain within a sequence conserved throughout the POU-domain family, confers these responses.
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Citations
Cited by
Calcium-Regulated Phosphorylation Within the Leucine Zipper of C/EBPβ
Wegner, M., Cao, Z., & Rosenfeld, M. G. (1992) · Science · doi:10.1126/science.256.5055.370 · Cited by 391
Self-citationHerr, W., & Cleary, M. A. (1995) · Genes & Development · doi:10.1101/gad.9.14.1679 · Cited by 388
Chinery, R., Brockman, J. A., Peeler, M. O., Shyr, Y., Beauchamp, R. D., & Coffey, R. J. (1997) · Nature Medicine · doi:10.1038/nm1197-1233 · Cited by 334
DNA binding specificity of homeodomains
Laughon, A. (1991) · Biochemistry · doi:10.1021/bi00112a001 · Cited by 285
Signal-specific co-activator domain requirements for Pit-1 activation
Xu, L., Lavinsky, R. M., Dasen, J. S., Flynn, S. E., McInerney, E. M., Mullen, T.-M., Heinzel, T., Szeto, D., Korzus, E., Kurokawa, R., et al. (1998) · Nature · doi:10.1038/26270 · Cited by 280
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Metadata
- Authors
- Kapiloff, M. S., Farkash, Y., Wegner, M., & Rosenfeld, M. G.
- Venue
- Science
- Published
- 1991-08-16
- Volume
- 253
- Issue
- 5021
- Pages
- 786-789
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2047466377
- Cited by
- 203
- References
- 0
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kapiloff, M. S., Farkash, Y., Wegner, M., & Rosenfeld, M. G. (1991). Variable Effects of Phosphorylation of Pit-1 Dictated by the DNA Response Elements. Science. https://doi.org/10.1126/science.1652153
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