The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Identification of a Site in Glutamate Receptor Subunits That Controls Calcium Permeability
Abstract
The neurotransmitter glutamate mediates excitatory synaptic transmission throughout the brain. A family of genes encoding subunits of the non- N -methyl-D-aspartate (non-NMDA) type of glutamate receptor has been cloned. Some combinations of these subunits assemble into receptors with a substantial permeability to calcium, whereas others do not. To investigate the structural features that control ion permeation through these ligand-gated channels, mutant receptor subunits with single-amino acid changes were constructed. Mutation of a certain amino acid that results in a net charge change (from glutamine to arginine or vice versa) alters both the current-voltage relation and the calcium permeability of non-NMDA receptors. A site has thus been identified that regulates the permeation properties of these glutamate receptors.
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Citations
Cites
A Family of AMPA-Selective Glutamate Receptors
Keinänen, K., Wisden, W., Sommer, B., Werner, P., Herb, A., Verdoorn, T. A., Sakmann, B., & Seeburg, P. H. (1990) · Science · doi:10.1126/science.2166337 · Cited by 1,479
Iino, M., Ozawa, S., & Tsuzuki, K. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018060 · Cited by 497
Cited by
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Traynelis, S. F., Wollmuth, L. P., McBain, C. J., Menniti, F. S., Vance, K. M., Ogden, K. K., Hansen, K. B., Yuan, H., Myers, S. J., & Dingledine, R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002451 · Cited by 3,568
Self-citationThe Glutamate Receptor Ion Channels
Dingledine, R., Borges, K., Bowie, D., & Traynelis, S. F. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01394-2 · Cited by 3,554
Self-citationHeteromeric NMDA receptors: molecular and functional distinction of subtypes
Monyer, H., Sprengel, R., Schoepfer, R., Herb, A., Higuchi, M., Lomeli, H., Burnashev, N., Sakmann, B., & Seeburg, P. H. (1992) · Science · doi:10.1126/science.256.5060.1217 · Cited by 2,541
Molecular diversity of glutamate receptors and implications for brain function
Nakanishi, S. (1992) · Science · doi:10.1126/science.1329206 · Cited by 2,543
Choi, D. W. (1992) · Journal of Neurobiology · doi:10.1002/neu.480230915 · Cited by 2,314
Metadata
- Authors
- Hume, R. I., Dingledine, R., & Heinemann, S. F.
- Venue
- Science
- Published
- 1991-08-30
- Volume
- 253
- Issue
- 5023
- Pages
- 1028-1031
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2090872672
- Cited by
- 765
- References
- 2
- FWCI
- 19.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hume, R. I., Dingledine, R., & Heinemann, S. F. (1991). Identification of a Site in Glutamate Receptor Subunits That Controls Calcium Permeability. Science. https://doi.org/10.1126/science.1653450
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