The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Regulation of Kainate Receptors by cAMP-Dependent Protein Kinase and Phosphatases
Abstract
In the mammalian central nervous system, receptors for excitatory amino acid neurotransmitters such as the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-kainate receptor mediate a large fraction of excitatory transmission. Currents induced by activation of the AMPA-kainate receptor were potentiated by agents that specifically stimulate adenosine 3′,5′-monophosphate (cAMP)-dependent protein kinase A (PKA) activity or were supported by intracellular application of the catalytic subunit of PKA by itself or in combination with cAMP. Furthermore, depression of these currents by a competitive inhibitor of PKA indicates that AMPA-kainate receptors are regulated by endogenous PKA. Endogenous protein phosphatases also regulate these receptors because an inhibitor of cellular phosphatases enhanced kainate currents. Modulation of PKA and phosphatases may regulate the function of these receptors and thus contribute to synaptic plasticity in hippocampal neurons.
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A Family of AMPA-Selective Glutamate Receptors
Keinänen, K., Wisden, W., Sommer, B., Werner, P., Herb, A., Verdoorn, T. A., Sakmann, B., & Seeburg, P. H. (1990) · Science · doi:10.1126/science.2166337 · Cited by 1,479
A persistent postsynaptic modification mediates long-term potentiation in the hippocampus
Kauer, J. A., Malenka, R. C., & Nicoll, R. A. (1988) · Neuron · doi:10.1016/0896-6273(88)90148-1 · Cited by 497
Iino, M., Ozawa, S., & Tsuzuki, K. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018060 · Cited by 497
Cited by
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
The Glutamate Receptor Ion Channels
Dingledine, R., Borges, K., Bowie, D., & Traynelis, S. F. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01394-2 · Cited by 3,554
Berridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529
Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons
Frey, U., Huang, Y.-Y., & Kandel, E. R. (1993) · Science · doi:10.1126/science.8389057 · Cited by 1,218
Contrasting properties of two forms of long-term potentiation in the hippocampus
Nicoll, R. A., & Malenka, R. C. (1995) · Nature · doi:10.1038/377115a0 · Cited by 854
Metadata
- Authors
- Wang, L.-Y., Salter, M. W., & MacDonald, J. F.
- Venue
- Science
- Published
- 1991-09-06
- Volume
- 253
- Issue
- 5024
- Pages
- 1132-1135
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1970706135
- Cited by
- 395
- References
- 3
- FWCI
- 14.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, L.-Y., Salter, M. W., & MacDonald, J. F. (1991). Regulation of Kainate Receptors by cAMP-Dependent Protein Kinase and Phosphatases. Science. https://doi.org/10.1126/science.1653455
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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