A persistent postsynaptic modification mediates long-term potentiation in the hippocampus
Abstract
Long-term potentiation (LTP) is a long-lasting enhancement of synaptic transmission that can be induced by brief repetitive stimulation of excitatory pathways in the hippocampus. One of the most controversial points is whether the process underlying the enhanced synaptic transmission occurs pre- or postsynaptically. To examine this question, we have taken advantage of the novel physiological properties of excitatory synaptic transmission in the CA1 region of the hippocampus. Synaptically released glutamate activates both NMDA and non-NMDA receptors on pyramidal cells, resulting in an excitatory postsynaptic potential (EPSP) with two distinct components. A selective increase in the non-NMDA component of the EPSP was observed with LTP. This result suggests that the enhancement of synaptic transmission during LTP is caused by an increased sensitivity of the postsynaptic neuron to synaptically released glutamate.
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The AMPA, but not NMDA, component of EPSPs is affected by LTP.
“Consistently, the AMPA, but not NMDA, component of EPSPs is affected by LTP404142.”
From State-dependent diffusion of actin-depolymerizing factor/cofilin underlies the enlargement and shrinkage of dendritic spines (2016) · cites this paper as [40]
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- Authors
- Kauer, J. A., Malenka, R. C., & Nicoll, R. A.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1988-12
- Volume
- 1
- Issue
- 10
- Pages
- 911-917
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2157365188
- Cited by
- 497
- References
- 1
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 8 · 2023: 8 · 2022: 7 · 2021: 12 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 6 · 2015: 4 · 2014: 8 · 2013: 13 · 2012: 7
- FWCI
- 13.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health (MH00437, MH38256, NS24205)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- long-term potentiation, hippocampus, CA1 region, non-NMDA receptors, NMDA receptor, excitatory postsynaptic potentials, glutamate sensitivity, synaptic transmission, pyramidal neurons
- MeSH terms
- Animals, Aspartic Acid, Glutamates, Hippocampus, Membrane Potentials, Synaptic Transmission, Quinoxalines, Synapses, Receptors, N-Methyl-D-Aspartate, N-Methylaspartate, Receptors, Neurotransmitter, 6-Cyano-7-nitroquinoxaline-2,3-dione, Rats
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