The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Molecular Cloning and Functional Expression of the Cardiac Sarcolemmal Na + -Ca 2+ Exchanger
Abstract
The Na + -Ca 2+ exchanger of the cardiac sarcolemma can rapidly transport Ca 2+ during excitation-contraction coupling. To begin molecular studies of this transporter, polyclonal antibodies were used to identify a complementary DNA (cDNA) clone encoding the Na + -Ca 2+ exchanger protein. The cDNA hybridizes with a 7-kilobase RNA on a Northern blot and has an open reading frame of 970 amino acids. Hydropathy analysis suggests that the protein has multiple transmembrane helices, and a small region of the sequence is similar to that of the Na + - and K + -dependent adenosine triphosphatase. Polyclonal antibodies to a synthetic peptide from the deduced amino acid sequence react with sarcolemmal proteins of 70, 120, and 160 kilodaltons on immunoblots. RNA, synthesized from the cDNA clone, induces expression of Na + -Ca 2+ exchange activity when injected into Xenopus oocytes.
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Cites
Do the poly(A) tail and 3’ untranslated region control mRNA translation?
Jackson, R. J., & Standart, N. (1990) · Cell · doi:10.1016/0092-8674(90)90235-7 · Cited by 590
Cited by
Cunningham, K. W., & Fink, G. R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2226 · Cited by 431
Calcium Signaling in Cardiac Myocytes
Fearnley, C. J., Roderick, H. L., & Bootman, M. D. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004242 · Cited by 339
Identification of a peptide inhibitor of the cardiac sarcolemmal Na(+)-Ca2+ exchanger.
Li, Z., Nicoll, D. A., Collins, A., Hilgemann, D. W., Filoteo, A. G., Penniston, J. T., Weiss, J. N., Tomich, J. M., & Philipson, K. D. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35276-6 · Cited by 275
Self-citationAnalysis of Ion Interactions with the K+ -dependent Na+/Ca+ Exchangers NCKX2, NCKX3, and NCKX4
Visser, F., Valsecchi, V., Annunziato, L., & Lytton, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610582200 · Cited by 46
Metadata
- Authors
- Nicoll, D. A., Longoni, S., & Philipson, K. D.
- Venue
- Science
- Published
- 1990-10-26
- Volume
- 250
- Issue
- 4980
- Pages
- 562-565
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059201211
- Cited by
- 742
- References
- 1
- FWCI
- 34.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nicoll, D. A., Longoni, S., & Philipson, K. D. (1990). Molecular Cloning and Functional Expression of the Cardiac Sarcolemmal Na + -Ca 2+ Exchanger. Science. https://doi.org/10.1126/science.1700476
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
