The DOI matches its Crossref record.
Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40
Abstract
CD40 is a 45- to 50-kilodalton transmembrane glycoprotein expressed on B lymphocytes, epithelial cells, and some carcinoma cell lines. Human resting B lymphocytes entered a state of sustained proliferation when incubated with both the mouse fibroblastic Ltk - cell line that had been transfected with the human Fc receptor (FcγRII/CDw32) and monoclonal antibodies to CD40. In combination with interleukin-4, factor-dependent long-term normal human B cell lines were generated that were consistently negative for Epstein-Barr viral infection. Thus, cross-linking of CD40 is likely to represent an important phenomenon in the clonal expansion of B cells.
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Citations
Cited by
Follicular Helper CD4 T Cells (T FH )
Crotty, S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101400 · Cited by 2,738
CD40 AND CD154 IN CELL-MEDIATED IMMUNITY
Grewal, I. S., & Flavell, R. A. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.111 · Cited by 1,539
Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes
Rousset, F., Garcia, E., Defrance, T., Péronne, C., Vezzio, N., Hsu, D. H., Kastelein, R., Moore, K. W., & Banchereau, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1890 · Cited by 1,238
Self-citationSenescence-associated reprogramming promotes cancer stemness
Milanovic, M., Fan, D. N. Y., Belenki, D., Däbritz, J. H. M., Zhao, Z., Yu, Y., Dörr, J. R., Dimitrova, L., Lenze, D., Monteiro Barbosa, I. A., et al. (2018) · Nature · doi:10.1038/nature25167 · Cited by 1,131
Kawabe, T., Naka, T., Yoshida, K., Tanaka, T., Fujiwara, H., Suematsu, S., Yoshida, N., Kishimoto, T., & Kikutani, H. (1994) · Immunity · doi:10.1016/1074-7613(94)90095-7 · Cited by 1,108
Metadata
- Authors
- Banchereau, J., de Paoli, P., Vallé, A., Garcia, E., & Rousset, F.
- Venue
- Science
- Published
- 1991-01-04
- Volume
- 251
- Issue
- 4989
- Pages
- 70-72
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2058050336
- Cited by
- 533
- References
- 0
- FWCI
- 23.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40. https://app.cochat.ai/papers/10.1126/science.1702555
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- Banchereau, J., de Paoli, P., Vallé, A., Garcia, E., & Rousset, F. (1991). Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40. Science. https://doi.org/10.1126/science.1702555
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
