Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

Handschumacher, R. E., Harding, M. W., Rice, J. S., Drugge, R. J., & Speicher, D. W. (1984) · Science · doi:10.1126/science.6238408 · Cited by 1,675

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

Fischer, G., Wittmann‐Liebold, B., Lang, K., Kiefhaber, T., & Schmid, F. X. (1989) · Nature · doi:10.1038/337476a0 · Cited by 1,408

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

Harding, M. W., Gałat, A., Uehling, D., & Schreiber, S. L. (1989) · Nature · doi:10.1038/341758a0 · Cited by 1,396

Cyclosporine

Oates, J. A., Wood, A. J. J., & Kahan, B. D. (1989) · New England Journal of Medicine · doi:10.1056/nejm198912213212507 · Cited by 1,351

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

Takahashi, N., Hayano, T., & Suzuki, M. (1989) · Nature · doi:10.1038/337473a0 · Cited by 1,075

Contingent Genetic Regulatory Events in T Lymphocyte Activation

Crabtree, G. R. (1989) · Science · doi:10.1126/science.2783497 · Cited by 1,071

FK 506 FOR LIVER, KIDNEY, AND PANCREAS TRANSPLANTATION

Starzl, T., Fung, J. J., Venkataraman, R., Todo, S., Demetris, A. J., & Jain, A. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91014-3 · Cited by 1,036

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

Siekierka, J. J., Hung, S. H. Y., Poe, M., Lin, C. S., & SIGAL, N. H. (1989) · Nature · doi:10.1038/341755a0 · Cited by 1,016

Identification of a Putative Regulator of Early T Cell Activation Genes

Shaw, J., Utz, P. J., Durand, D. B., Toole, J. J., Emmel, E. A., & Crabtree, G. R. (1988) · Science · doi:10.1126/science.3260404 · Cited by 946

Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells

Rothman, J. E. (1989) · Cell · doi:10.1016/0092-8674(89)90005-6 · Cited by 887

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

Bierer, B. E., Mattila, P. S., Standaert, R. F., Herzenberg, L. A., Burakoff, S. J., Crabtree, G. R., & Schreiber, S. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.23.9231 · Cited by 706

Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation

Emmel, E. A., Verweij, C. L., Durand, D. B., Higgins, K. M., Lacy, E., & Crabtree, G. R. (1989) · Science · doi:10.1126/science.2595372 · Cited by 664

The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes.

Tocci, M. J., Matkovich, D. A., Collier, K., Kwok, P., Dumont, F. J., Lin, S., DeGudicibus, S. J., Siekierka, J. J., Chin, J., & Hutchinson, N. I. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.2.718 · Cited by 661

Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin.

Dumont, F. J., Staruch, M. J., Koprak, S., Melino, M. R., & SIGAL, N. H. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.1.251 · Cited by 602

Activators and targets

Ptashne, M., & Gann, A. A. F. (1990) · Nature · doi:10.1038/346329a0 · Cited by 455

Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta

Gunasekera, S. P., Gunasekera, M., Longley, R. E., & Schulte, G. K. (1990) · The Journal of Organic Chemistry · doi:10.1021/jo00303a029 · Cited by 377

The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells.

Dumont, F. J., Melino, M. R., Staruch, M. J., Koprak, S., Fischer, P. A., & SIGAL, N. H. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.4.1418 · Cited by 355

Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand

Bierer, B. E., Somers, P. K., Wandless, T. J., Burakoff, S. J., & Schreiber, S. L. (1990) · Science · doi:10.1126/science.1700475 · Cited by 351

South Africa

Kandela, P. (1985) · The Lancet · doi:10.1016/s0140-6736(85)90538-0 · Cited by 333

Molecular cloning and overexpression of the human FK506-binding protein FKBP

Standaert, R. F., Gałat, A., Verdine, G. L., & Schreiber, S. L. (1990) · Nature · doi:10.1038/346671a0 · Cited by 312

Substrate specificities of the peptidyl prolyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein: evidence for the existence of a family of distinct enzymes

Harrison, R. K., & Stein, R. L. (1990) · Biochemistry · doi:10.1021/bi00468a001 · Cited by 301

Liver Transplantation

Starzl, T. E., Demetris, A. J., & Thiel, D. H. V. (1989) · New England Journal of Medicine · doi:10.1056/nejm198910193211606 · Cited by 292

The ninaA gene required for visual transduction in Drosophila encodes a homologue of cyclosporin A-binding protein

Shieh, B., Stamnes, M. A., Seavello, S., Harris, G. L., & Zuker, C. S. (1989) · Nature · doi:10.1038/338067a0 · Cited by 278

Total synthesis of FK506 and an FKBP probe reagent, [C(8),C(9)-13C2]-FK506

Nakatsuka, M., Ragan, J. A., Sammakia, T., Smith, D. B., Uehling, D., & Schreiber, S. L. (1990) · Journal of the American Chemical Society · doi:10.1021/ja00170a024 · Cited by 257

Cloning, expression, and purification of human cyclophilin in Escherichia coli and assessment of the catalytic role of cysteines by site-directed mutagenesis.

Liu, J., Albers, M. W., Chen, C., Schreiber, S. L., & Walsh, C. T. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.6.2304 · Cited by 246

Peptidyl-prolyl cis-trans-isomerase from Escherichia coli: a periplasmic homolog of cyclophilin that is not inhibited by cyclosporin A.

Liu, J., & Walsh, C. T. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.11.4028 · Cited by 235

Kidney Transplantation Under FK 506

Starzl, T. E. (1990) · JAMA · doi:10.1001/jama.1990.03450010067032 · Cited by 234

Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisiae

Tropschug, M., Bartheimess, I. B., & Neupert, W. (1989) · Nature · doi:10.1038/342953a0 · Cited by 216

Inhibition of FKBP Rotamase Activity by Immunosuppressant FK506: Twisted Amide Surrogate

Rosen, M. K., Standaert, R. F., Gałat, A., Nakatsuka, M., & Schreiber, S. L. (1990) · Science · doi:10.1126/science.1693013 · Cited by 201

Drosophila ninaA gene encodes an eye-specific cyclophilin (cyclosporine A binding protein).

Schneuwly, S., Shortridge, R. D., Larrivee, D. C., Ono, T., Ozaki, M., & Pak, W. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.14.5390 · Cited by 195

Towards a better definition of human leucocyte surface molecules

Knapp, W., RIEBER, P., Dörken, B., Schmidt, R. E., Stein, H., & Borne, A. E. G. K. V. D. (1989) · Immunology Today · doi:10.1016/0167-5699(89)90135-7 · Cited by 194

FK-506 — How much potential?

Thomson, A. W. (1989) · Immunology Today · doi:10.1016/0167-5699(89)90057-1 · Cited by 181

Mechanistic studies of peptidyl prolyl cis-trans isomerase: evidence for catalysis by distortion

Harrison, R. K., & Stein, R. L. (1990) · Biochemistry · doi:10.1021/bi00459a003 · Cited by 166

Isolation and sequence of an FK506-binding protein from N. crassa which catalyses protein folding

Tropschug, M., Wächter, E., Mayer, S., Schönbrunner, E. R., & Schmid, F. X. (1990) · Nature · doi:10.1038/346674a0 · Cited by 153

Cyclophilin binds to the region of cyclosporine involved in its immunosuppressive activity

Quesniaux, V. F. J., Schreier, M., Wenger, R. M., HIESTAND, P. C., Harding, M. W., & Regenmortel, M. H. V. V. (1987) · European Journal of Immunology · doi:10.1002/eji.1830170921 · Cited by 147

FK-506, a potent novel immunosuppressive agent, binds to a cytosolic protein which is distinct from the cyclosporin A-binding protein, cyclophilin.

Siekierka, J. J., Staruch, M. J., Hung, S. H. Y., & SIGAL, N. H. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.5.1580 · Cited by 140

Rapamycin and FK506 binding proteins (immunophilins)

Fretz, H., Albers, M. W., Gałat, A., Standaert, R. F., Lane, W. S., Burakoff, S. J., Bierer, B. E., & Schreiber, S. L. (1991) · Journal of the American Chemical Society · doi:10.1021/ja00004a051 · Cited by 134

Substrate specificity for the human rotamase FKBP: a view of FK506 and rapamycin as leucine-(twisted amide)-proline mimics

Albers, M. W., Walsh, C. T., & Schreiber, S. L. (1990) · The Journal of Organic Chemistry · doi:10.1021/jo00304a003 · Cited by 122

Complementary DNA encoding the human T-cell FK506-binding protein, a peptidylprolyl cis-trans isomerase distinct from cyclophilin.

Maki, N., Sekiguchi, F., Nishimaki, J., Miwa, K., Hayano, T., Takahashi, N., & Suzuki, M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5440 · Cited by 119

Cytoplasmic anchoring proteins and the control of nuclear localization

Hunt, T. (1989) · Cell · doi:10.1016/0092-8674(89)90747-2 · Cited by 106

The affairs of daughterless and the promiscuity of developmental regulators

Cline, T. W. (1989) · Cell · doi:10.1016/0092-8674(89)90280-8 · Cited by 97

CYCLOSPORINE, FK506, AND RAPAMYCIN

Metcalfe, S. M., & Richards, F. M. (1990) · Transplantation · doi:10.1097/00007890-199004000-00028 · Cited by 96

CYCLOPHILIN, A PRIMARY MOLECULAR TARGET FOR CYCLOSPORINE

Harding, M. W., & Handschumacher, R. E. (1988) · Transplantation · doi:10.1097/00007890-198808001-00006 · Cited by 95

HEPATOTROPHIC EFFECTS OF FK506 IN DOGS

Starzl, T. E., Porter, K. A., Mazzaferro, V., Todo, S., Fung, J. J., & Francavilla, A. (1991) · Transplantation · doi:10.1097/00007890-199101000-00010 · Cited by 75

A second cyclophilin-related gene inSaccharomyces cerevisiae

Koser, P. L., Sylvester, D., Livi, G. P., & Bergsma, D. J. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.6.1643 · Cited by 64

Cyclosporin A inhibits degranulation of rat basophilic leukemia cells and human basophils. Inhibition of mediator release without affecting PI hydrolysis or Ca2+ fluxes.

Hultsch, T., Rodriguez, J. L., Kaliner, M., & Hohman, R. J. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.7.2659 · Cited by 62

The design and synthesis of immune regulatory agents: Targets and approaches

Devlin, J. P., & Hargrave, K. D. (1989) · Tetrahedron · doi:10.1016/s0040-4020(01)89072-4 · Cited by 57

The Effect of Cyclosporine on the Use of Hospital Resources for Kidney Transplantation

Showstack, J. A., Katz, P., AMEND, W. J. C., Bernstein, L., Lipton, H., O'Leary, M., Bindman, A. B., & Salvatierra, O. (1989) · New England Journal of Medicine · doi:10.1056/nejm198910193211605 · Cited by 56

Nuclear factors interacting with the mitogen-responsive regulatory region of the interleukin-2 gene.

Brunvand, M. W., Schmidt, A., & Siebenlist, U. K. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37368-x · Cited by 52

Kinetic β‐deuterium isotope effects suggest a covalent mechanism for the protein folding enzyme peptidylprolyl cis/trans‐isomerase

Fischer, G. S., Berger, E., & Bang, H. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)80735-5 · Cited by 48

s‐Cisand s‐transisomerism in acylproline analogs

Galardy, R. E., Alger, J., & Liakopoulou-Kyriakides, M. T. (1982) · International journal of peptide & protein research · doi:10.1111/j.1399-3011.1982.tb02599.x · Cited by 35

A study of the correlation between cyclophilin binding and in vitro immunosuppressive activity of cyclosporine A and analogues.

Durette, P. L., Boger, J., Dumont, F. J., Firestone, R. A., Frankshun, R. A., Koprak, S., Cs, L., Mr, M., Aa, P., & Pisano, J. M. (1988) · PubMed · Cited by 27

A COMPARISON OF CYCLOSPORINE BINDING BY CYCLOPHILIN AND CALMODULIN AND THE IDENTIFICATION OF A NOVEL 45 KD CYCLOSPORINE-BINDING PHOSPHOPROTEIN IN JURKAT CELLS

Foxwell, B. M. J., HIESTAND, P. C., Wenger, R. M., & Ryffel, B. (1988) · Transplantation · doi:10.1097/00007890-198808001-00007 · Cited by 22

Effects of spergualin and 15-deoxyspergualin on the development of graft-versus-host disease in mice.

Nemoto, K., Ito, J., Hayashi, M., Abe, F., Ohtaka, Y., Nakamura, T., Takeuchi, T., & Umezawa, H. (1987) · PubMed · Cited by 10

Is there a scaffolding domain within the structure of the immunosuppressive agent cyclosporin a (CsA)? Studies of the cyclophilin binding domain of CsA

Schreiber, S. L., Anthony, N. J., Dorsey, B. D., & Hawley, R. C. (1988) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)82401-6 · Cited by 6

TGF-β SIGNAL TRANSDUCTION

Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571

Protein folding in the cell

Gething, M.-J. H., & Sambrook, J. (1992) · Nature · doi:10.1038/355033a0 · Cited by 4,158

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116

The mechanism of action of cyclosporin A and FK506

Schreiber, S. L., & Crabtree, G. R. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90111-j · Cited by 2,127

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

Brown, E. J., Albers, M. W., Bum Shin, T., ichikawa, K., Keith, C. T., Lane, W. S., & Schreiber, S. L. (1994) · Nature · doi:10.1038/369756a0 · Cited by 2,053

Immunophilins in protein folding and immunosuppression 1

Fruman, D. A., Burakoff, S. J., & Bierer, B. E. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.6.7513288 · Cited by 249

REVIEWS Immunophilins in protein folding and immunosuppression1

Vruman, D. A., Burakoff, S. J., & Bierer*tll, B. E. (2013)

Immunophilin Receptors for Immunosuppressive Drugs

Soldin, S. J., Murthy, J. N., Donnelly, J. G., Chen, Y., & Goodyear, N. (1993) · Therapeutic Drug Monitoring · doi:10.1097/00007691-199312000-00002 · Cited by 10

Chapter 22. Immunophilins and Immunosuppressive Drug Action

Armistead, D. M., & Harding, M. W. (1993) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(08)60892-1 · Cited by 10

The molecular mechanism of immunophilin binding immunosuppressant

Zhang, W. (2002) · Zhongguo yaolixue yu dulixue zazhi