Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

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Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

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A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

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Cyclosporine

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Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

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FK 506 FOR LIVER, KIDNEY, AND PANCREAS TRANSPLANTATION

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A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

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Identification of a Putative Regulator of Early T Cell Activation Genes

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Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells

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TGF-β SIGNAL TRANSDUCTION

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Protein folding in the cell

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

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The mechanism of action of cyclosporin A and FK506

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A mammalian protein targeted by G1-arresting rapamycin–receptor complex

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

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Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

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Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

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RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

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The tor pathway: a target for cancer therapy

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Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

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Molten Globule and Protein Folding

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

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mTOR as a central hub of nutrient signalling and cell growth

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Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

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Targeted protein degradation: mechanisms, strategies and application

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Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR

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Calcium Absorption Across Epithelia

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Structure of the FKBP12-Rapamycin Complex Interacting with Binding Domain of Human FRAP

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Microarrays of cells expressing defined cDNAs

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Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

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A human peptidyl–prolyl isomerase essential for regulation of mitosis

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Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design

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Controlling Signal Transduction with Synthetic Ligands

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Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

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Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein

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Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.

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Mechanisms of action of cyclosporine.

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Sequence-Specific and Phosphorylation-Dependent Proline Isomerization: A Potential Mitotic Regulatory Mechanism

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Autophagy in metazoans: cell survival in the land of plenty

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Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function

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Rapamycin blocks the phosphorylation of 4E‐BP1 and inhibits cap‐dependent initiation of translation.

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Heat shock proteins: molecular chaperones of protein biogenesis

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Features of Selective Kinase Inhibitors

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Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase

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Atomic Structure of FKBP-FK506, an Immunophilin-Immunosuppressant Complex

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Functional association of cyclophilin A with HIV-1 virions

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Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

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Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae

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The Rise of Molecular Glues

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The CH/π interaction: Significance in molecular recognition

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Molecular chaperones and protein folding in plants

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Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

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Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

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Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificity

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Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

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Proline-Dependent Structural and Biological Properties of Peptides and Proteins

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Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.

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Regulation of eIF-4E BP1 Phosphorylation by mTOR

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Mechanisms of drug release in nanotherapeutic delivery systems

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Nuclear factor of activated T cells contains Fos and Jun

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Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases.Preprint

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Inhibition of Intimal Thickening After Balloon Angioplasty in Porcine Coronary Arteries by Targeting Regulators of the Cell Cycle

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Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domainPreprint

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Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia

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Cyclophilin B Is a Functional Regulator of Hepatitis C Virus RNA Polymerase

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Bench to Bedside

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Crystal Structure of the Cytoplasmic Domain of the Type I TGF β Receptor in Complex with FKBP12

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Overview of interleukin-2 function, production and clinical applications

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Coupled Gating Between Individual Skeletal Muscle Ca 2+ Release Channels (Ryanodine Receptors)

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Chemical genetics resulting from a passion for synthetic organic chemistry

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Coupled Gating Between Cardiac Calcium Release Channels (Ryanodine Receptors)

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Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

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Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: One in the presence and one in the absence of CsA

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FK506 and cyclosporin, molecular probes for studying intracellular signal transduction

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Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae

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Mechanism of TGFβ receptor inhibition by FKBP12

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Mechanism of action of the immunosuppressant rapamycin

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Absolute Binding Free Energy Calculations Using Molecular Dynamics Simulations with Restraining Potentials

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Tacrolimus

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The calcium release channel of sarcoplasmic reticulum is modulated by FK-506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum.

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Pharmacology of the Eosinophil

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High brain densities of the immunophilin FKBP colocalized with calcineurin

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Immunophilin-sensitive protein phosphatase action in cell signaling pathways

Schreiber, S. L. (1992) · Cell · doi:10.1016/0092-8674(92)90158-9 · Cited by 342

Peptidylproline cis‐trans‐isomerases: immunophilins

Gałat, A. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18189.x · Cited by 345

AKAP Mediated Signal Transduction

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Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A

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The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteinsPreprint

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Protein Expression Profiles in Pancreatic Adenocarcinoma Compared with Normal Pancreatic Tissue and Tissue Affected by Pancreatitis as Detected by Two-Dimensional Gel Electrophoresis and Mass Spectrometry

Shen, J., Person, M. D., Zhu, J., Abbruzzese, J. L., & Li, D. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-3262 · Cited by 337

THE ROLE OF THEhsp90-BASED CHAPERONE SYSTEM IN SIGNAL TRANSDUCTION BY NUCLEAR RECEPTORS AND RECEPTORS SIGNALING VIA MAP KINASE

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Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models

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Mechanisms of Clinically Relevant Drug Interactions Associated with Tacrolimus

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The cyclophilin homolog ninaA is required in the secretory pathway

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mTOR signaling and its roles in normal and abnormal brain development

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Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells.

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Dominant Missense Mutations in a Novel Yeast Protein related to Mammalian Phosphatidylinositol 3-Kinase and VPS34 Abrogate Rapamycin Cytotoxicity

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Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720

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Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex

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Solution Structure of FKBP, a Rotamase Enzyme and Receptor for FK506 and Rapamycin

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The cyclophilin homolog NinaA functions as a chaperone, forming a stable complex in vivo with its protein target rhodopsin.

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Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases

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A three-hybrid system for detecting small ligand–protein receptor interactions

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Chemical Genetics

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