The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
A Portal Blood Factor as the Humoral Agent in Liver Regeneration
Abstract
It was demonstrated, by use of extracorporeal cross-circulation, that a humoral factor responsible for liver regeneration does not arise from the liver remnant. While intact livers of normal rats incorporated [methyl- 3 H]thymidine in proportion to the amount of liver removed in the partner, the greatest response occurred after a total hepatectomy. Evidence from portacaval-shunted, partially hepatectomized animals connected to normal members indicates that the factor is in portal blood and that the onset of regeneration is the result of a quantitative imbalance between the available portal blood factor and the number of liver cells present.
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“Moreover, in experiments where the portal circulations of two animals are connected via a shunt, hepatectomy in one animal induces liver growth in the other, despite the absence of direct liver tissue damage[40,41].”
From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [40]
In the citing paper
“Convincing evidence has been found that mitogenic signals for hepatocytes are transported in the blood 2,3 and that they induce a number of immediate early genes within 30 minutes after PH. 4”
From Interleukin 6 Is Important for Survival After Partial Hepatectomy in Mice (2003) · cites this paper as [2]
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- Fisher, B., Cancer Research 31: 322 (1971).
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Metadata
- Authors
- Fisher, B., Szuch, P., Levine, M., & Fisher, E. R.
- Affiliations
- University of Pittsburgh (US)
- ORCID
- Fisher, Bernard
- Venue
- Science
- Published
- 1971-02-12
- Volume
- 171
- Issue
- 3971
- Pages
- 575-577
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2038241495
- Cited by
- 161
- References
- 7
- Citations by year
- 2025: 1 · 2023: 1 · 2020: 2 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 3
- FWCI
- 15.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- liver regeneration, humoral factors, portal blood, partial hepatectomy, portacaval shunt, thymidine incorporation, remnant liver
- MeSH terms
- Animals, Blood, DNA, Female, Hepatectomy, Liver, Liver Circulation, Liver Regeneration, Parabiosis, Portacaval Shunt, Surgical, Thymidine, Tritium, Rats
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