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Cited by 161Liver physiology and pathologyOrgan Transplantation Techniques and OutcomesTissue Engineering and Regenerative Medicine

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

A Portal Blood Factor as the Humoral Agent in Liver Regeneration

Fisher, Bernard, Szuch, Patricia, Levine, Morton, Fisher, Edwin R.·1971·Science
DOI 10.1126/science.171.3971.575
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Abstract

It was demonstrated, by use of extracorporeal cross-circulation, that a humoral factor responsible for liver regeneration does not arise from the liver remnant. While intact livers of normal rats incorporated [methyl- 3 H]thymidine in proportion to the amount of liver removed in the partner, the greatest response occurred after a total hepatectomy. Evidence from portacaval-shunted, partially hepatectomized animals connected to normal members indicates that the factor is in portal blood and that the onset of regeneration is the result of a quantitative imbalance between the available portal blood factor and the number of liver cells present.

Overview

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Crossref · 10.1126/science.171.3971.575

Cites

7 of 7 references verified0 citation errors · 0 not checkable

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Citations

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Research works printed but not linked: 3

  1. CHRISTENSEN, B.G., ACTA MEDICA SCANDINAVICA 234: 103 (1949).
  2. Fisher, B., Cancer Research 31: 322 (1971).
  3. Glinos, A. D., Symposium on the Chemical Basis of Development: 813 (1958).

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Metadata

Authors
Fisher, B., Szuch, P., Levine, M., & Fisher, E. R.
Affiliations
University of Pittsburgh (US)
ORCID
Fisher, Bernard
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1971-02-12
Volume
171
Issue
3971
Pages
575-577
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.171.3971.575
OpenAlex
W2038241495
Cited by
161
References
7
Citations by year
2025: 1 · 2023: 1 · 2020: 2 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 3
FWCI
15.53
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
liver regeneration, humoral factors, portal blood, partial hepatectomy, portacaval shunt, thymidine incorporation, remnant liver
MeSH terms
Animals, Blood, DNA, Female, Hepatectomy, Liver, Liver Circulation, Liver Regeneration, Parabiosis, Portacaval Shunt, Surgical, Thymidine, Tritium, Rats

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