The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Possible Etiology of Schizophrenia: Progressive Damage to the Noradrenergic Reward System by 6-Hydroxydopamine
Abstract
Single or repeated intraventricular injections of 6-hydroxydopamine caused marked and long-lasting deficits in brain self-stimulation and other rewarded behaviors in the rat. The behavioral deficits, as well as the depletion of brain norepinephrine induced by 6-hydroxydopamine, were prevented by prior treatment with chlorpromazine. Episodic or continuous formation of endogenous 6-hydroxydopamine in man as a result of a genetically determined enzymatic error could selectively damage the binding capacity and, eventually, the structural integrity of the noradrenergic reward mechanism. Such damage might cause the fundamental symptoms and long-term downhill course of schizophrenia.
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Cites
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Schizotaxia, schizotypy, schizophrenia.
Meehl, P. E. (1962) · American Psychologist · doi:10.1037/h0041029 · Cited by 2,019
Teitelbaum, P., & Epstein, A. N. (1962) · Psychological Review · doi:10.1037/h0039285 · Cited by 883
EFFECTS OF 6‐HYDROXYDOPAMINE ON CATECHOLAMINE CONTAINING NEURONES IN THE RAT BRAIN
Uretsky, N. J., & Iversen, L. L. (1970) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1970.tb02210.x · Cited by 653
Udenfriend, S. (1966) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)07173-x · Cited by 501
Breese, G. R., & Traylor, D. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/xd59-xs65 · Cited by 487
Osmond, H., & Smythies, J. (1952) · Journal of Mental Science · doi:10.1192/bjp.98.411.309 · Cited by 472
Hypothalamic Substrates of Reward
Olds, J. (1962) · Physiological Reviews · doi:10.1152/physrev.1962.42.4.554 · Cited by 469
Lesions of Central Norepinephrine Terminals with 6-OH-Dopamine: Biochemistry and Fine Structure
Bloom, F. E., Algeri, S., Groppetti, A., Revuelta, A., & Costa, E. (1969) · Science · doi:10.1126/science.166.3910.1284 · Cited by 420
Morphological and Functional Aspects of Central Monoamine Neurons
(1970) · International Review of Neurobiology · doi:10.1016/s0074-7742(08)60167-1 · Cited by 352
Cited by
The neuropsychology of schizophrenia
Gray, J. A., Feldon, J., Rawlins, J. N. P., Hemsley, D. R., & Smith, A. D. (1991) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00065055 · Cited by 1,350
The Dopamine Hypothesis of Schizophrenia: A Review*
Meltzer, H. Y., & Stahl, S. M. (1976) · Schizophrenia Bulletin · doi:10.1093/schbul/2.1.19 · Cited by 883
Swerdlow, N. R., & Koob, G. F. (1987) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00047488 · Cited by 674
The neuropsychology of 3-D space.
Previc, F. H. (1998) · Psychological Bulletin · doi:10.1037/0033-2909.124.2.123 · Cited by 604
Akiskal, H. S., & McKinney, W. T. (1973) · Science · doi:10.1126/science.182.4107.20 · Cited by 389
Metadata
- Authors
- Stein, L., & Wise, C. D.
- Venue
- Science
- Published
- 1971-03-12
- Volume
- 171
- Issue
- 3975
- Pages
- 1032-1036
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993738089
- Cited by
- 477
- References
- 32
- FWCI
- 14.80
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
