The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Regulation of Rransendothelial Neutrophil Migration by Endogenous Interleukin-8
Abstract
Movement of neutrophils from the bloodstream to inflamed tissue depends on the activation of both the neutrophil and the endothelial cell. Endothelial cells lining the postcapillary venule respond to proinflammatory mediators by expressing adhesion molecules and synthesizing a variety of neutrophil-activating factors. Endothelial cell production of a 77-amino acid variant of interleukin-8 (IL-8) was found to be a requirement for the invasion of neutrophils through a vessel wall model. IL-8 secreted by cytokine- or lipopolysaccharide-stimulated endothelial cells induced the rapid shedding of neutrophil lectin adhesion molecule-1, the up-regulation of leukocyte β 2 integrins, and the attachment and transmigration of the neutrophils. Thus, endogenous endothelial IL-8 regulates transvenular traffic during acute inflammatory responses.
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Citations
Cites
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
Yayon, A., Klagsbrun, M., Esko, J. D., Leder, P., & Ornitz, D. M. (1991) · Cell · doi:10.1016/0092-8674(91)90512-w · Cited by 2,440
Cited by
Interleukin-8 as a macrophage-derived mediator of angiogenesis
Koch, A. E., Polverini, P. J., Kunkel, S. L., Harlow, L. A., DiPietro, L. A., Elner, V. M., Elner, S. G., & Strieter, R. M. (1992) · Science · doi:10.1126/science.1281554 · Cited by 2,135
Self-citationNeutrophil granules and secretory vesicles in inflammation
Faurschou, M., & Borregaard, N. (2003) · Microbes and Infection · doi:10.1016/j.micinf.2003.09.008 · Cited by 1,162
Essential involvement of interleukin-8 (IL-8) in acute inflammation
Harada, A., Sekido, N., Akahoshi, T., Wada, T., Mukaida, N., & Matsushima, K. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.56.5.559 · Cited by 1,041
T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-lβ
Tanaka, Y., Adams, D. H., Hubscher, S., Hirano, H., Siebenlist, U., & Shaw, S. (1993) · Nature · doi:10.1038/361079a0 · Cited by 873
Cytokine regulation of endothelial cell function
Mantovani, A., Bussolino, F., & Dejana, E. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.8.1592209 · Cited by 678
Metadata
- Authors
- Huber, A. R., Kunkel, S. L., Todd, R. F., & Weiss, S. J.
- Venue
- Science
- Published
- 1991-10-04
- Volume
- 254
- Issue
- 5028
- Pages
- 99-102
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059289753
- Cited by
- 814
- References
- 2
- FWCI
- 13.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Huber, A. R., Kunkel, S. L., Todd, R. F., & Weiss, S. J. (1991). Regulation of Rransendothelial Neutrophil Migration by Endogenous Interleukin-8. Science. https://doi.org/10.1126/science.1718038
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