The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Identification of a Competitive HGF Antagonist Encoded by an Alternative Transcript
Abstract
We identified a naturally occurring hepatocyte growth factor (HGF) variant, whose predicted sequence extends only through the second kringle domain of this plasminogen-related molecule. This smaller molecule, derived from an alternative HGF transcript, lacked mitogenic activity but specifically inhibited HGF-induced mitogenesis. Cross-linking studies demonstrated that the truncated molecule competes with HGF for binding to the HGF receptor, which has been identified as the c- met protooncogene product. Thus, the same gene encodes both a growth factor and its direct antagonist.
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Saiki, R. K., Scharf, S., Faloona, F., Mullis, K. B., Horn, G. T., Erlich, H. A., & Arnheim, N. (1985) · Science · doi:10.1126/science.2999980 · Cited by 8,956
Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor
Hannum, C. H., Wilcox, C. J., Arend, W. P., Joslin, F. G., Dripps, D. J., Heimdal, P. L., Armes, L. G., Sommer, A., Eisenberg, S. P., & Thompson, R. C. (1990) · Nature · doi:10.1038/343336a0 · Cited by 1,122
Carter, D. B., Deibel, M. R., Dunn, C. J., Tomich, C.-S. C., Laborde, A. L., Slightom, J. L., Berger, A. E., Bienkowski, M. J., Sun, F. F., McEwan, R. N., et al. (1990) · Nature · doi:10.1038/344633a0 · Cited by 601
Cited by
Houck, K. A., Leung, D. W., Rowland, A. M., Winer, J., & Ferrara, N. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35712-0 · Cited by 1,127
Drug development of MET inhibitors: targeting oncogene addiction and expedience
Comoglio, P. M., Giordano, S., & Trusolino, L. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2530 · Cited by 818
Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
Bafico, A., Liu, G., Yaniv, A., Gazit, A., & Aaronson, S. A. (2001) · Nature Cell Biology · doi:10.1038/35083081 · Cited by 772
Self-citationScatter-factor and semaphorin receptors: cell signalling for invasive growth
Trusolino, L., & Comoglio, P. M. (2002) · Nature Reviews Cancer · doi:10.1038/nrc779 · Cited by 745
Weidner, K. M., Sachs, M., & Birchmeier, W. (1993) · The Journal of cell biology · doi:10.1083/jcb.121.1.145 · Cited by 408
Metadata
- Authors
- Chan, A. M.-L., Rubin, J. S., Bottaro, D. P., Hirschfield, D. W., Chedid, M., & Aaronson, S. A.
- Venue
- Science
- Published
- 1991-11-29
- Volume
- 254
- Issue
- 5036
- Pages
- 1382-1385
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2041705218
- Cited by
- 218
- References
- 3
- FWCI
- 11.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chan, A. M.-L., Rubin, J. S., Bottaro, D. P., Hirschfield, D. W., Chedid, M., & Aaronson, S. A. (1991). Identification of a Competitive HGF Antagonist Encoded by an Alternative Transcript. Science. https://doi.org/10.1126/science.1720571
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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