The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Participation of Postsynaptic PKC in Cerebellar Long-Term Depression in Culture
Abstract
Long-term depression (LTD) in the intact cerebellum is a decrease in the efficacy of the parallel fiber-Purkinje neuron synapse induced by coactivation of climbing fiber and parallel fiber inputs. In cultured Purkinje neurons, a similar depression can be induced by iontophoretic glutamate pulses and Purkinje neuron depolarization. This form of LTD is expressed as a depression of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA)-mediated current, and its induction is dependent on activation of metabotropic quisqualate receptors. The effect of inhibitors of protein kinase C (PKC) on LTD induction was studied. Inhibitors of PKC blocked LTD induction, while phorbol-12,13-diacetate (PDA), a PKC activator, mimicked LTD. These results suggest that PKC activation is necessary for the induction of cerebellar LTD.
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Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Hebb, D. O. (2005) · doi:10.4324/9781410612403 · Cited by 9,825
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Cited by
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms
Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323
AMPA receptor trafficking at excitatory synapses
Bredt, D. S., & Nicoll, R. A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00640-8 · Cited by 1,150
AMPARs and Synaptic Plasticity: The Last 25 Years
Huganir, R. L., & Nicoll, R. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.025 · Cited by 968
The cell biology of synaptic plasticity: AMPA receptor trafficking
Shepherd, J. D., & Huganir, R. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123516 · Cited by 978
Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice
Alba, A., Kano, M., Chen, C., Stanton, M. E., Fox, G. D., Herrup, K., Zwingman, T. A., & Tonegawa, S. (1994) · Cell · doi:10.1016/0092-8674(94)90205-4 · Cited by 934
Metadata
- Authors
- Linden, D. J., & Connor, J. A.
- Venue
- Science
- Published
- 1991-12-13
- Volume
- 254
- Issue
- 5038
- Pages
- 1656-1659
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2000853989
- Cited by
- 353
- References
- 3
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- closed
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