The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan Levels
Abstract
Brain serotonin concentrations at 1 p.m. were significantly elevated 1 hour after rats received a dose of L-tryptophan (12.5 milligrams per kilogram. intraperitoneally) smaller than one-twentieth of the normal daily dietary intake. Plasma and brain tryptophan levels were elevated 10 to 60 minutes after the injection, but they never exceeded the concentrations that occur nocturnally in untreated animals as a result of their normal 24-hour rhythms. These data suggest that physiological changes in plasma tryptophan concentration influence brain serotonin levels.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The determination of tryptophan in plasma, liver, and urine.
Denckla, W. D., & Dewey, H. K. (1967) · PubMed · Cited by 823
Pozefsky, T., Felig, P., Tobin, J. D., Soeldner, J. S., & Cahill, G. F. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106193 · Cited by 439
THE EFFECTS OF PRECURSOR LOADING IN THE CEREBRAL METABOLISM OF 5‐HYDROXYINDOLES
Moir, A. T. B., & Eccleston, D. (1968) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1968.tb06827.x · Cited by 396
Tryptophan Hydroxylation in Mammalian Systems
LOVENBERG, W., JEQUIER, E., & SJOERDSMA, A. (1968) · Advances in Pharmacology · doi:10.1016/s1054-3589(08)61153-9 · Cited by 193
Daily Rhythms in the Concentrations of Various Amino Acids in Human Plasma
Wurtman, R. J., Rose, C. M., Chou, C., & Larin, F. F. (1968) · New England Journal of Medicine · doi:10.1056/nejm196807252790401 · Cited by 192
Self-citationSensory Feedback in Regulation of Body Weight: is there a Ponderostat?
CABANAC, M., DUCLAUX, R., & SPECTOR, N. H. (1971) · Nature · doi:10.1038/229125a0 · Cited by 188
ASHCROFT, G. W., ECCLESTON, D., & CRAWFORD, T. B. B. (1965) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1965.tb06775.x · Cited by 177
McKean, C. M., Boggs, D. E., & Peterson, N. A. (1968) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1968.tb06202.x · Cited by 166
Circadian rhythms in rat mid‐brain and caudate nucleus biogenic amine levels
Friedman, A. H., & Walker, C. A. (1968) · The Journal of Physiology · doi:10.1113/jphysiol.1968.sp008547 · Cited by 158
Differences in circadian rhythms in 5-hydroxytryptamine according to brain region
Quay, W. B. (1968) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1968.215.6.1448 · Cited by 150
Cited by
Brain Serotonin Content: Physiological Regulation by Plasma Neutral Amino Acids
Fernstrom, J. D., & Wurtman, R. J. (1972) · Science · doi:10.1126/science.178.4059.414 · Cited by 1,160
Self-citationRole of Serotonin in the Paradoxical Calming Effect of Psychostimulants on Hyperactivity
Gainetdinov, R. R., Wetsel, W. C., Jones, S. R., Levin, E. D., Jaber, M., & Caron, M. G. (1999) · Science · doi:10.1126/science.283.5400.397 · Cited by 885
Tryptophan metabolism in the central nervous system: medical implications
Ruddick, J. P., Evans, A. K., Nutt, D. J., Lightman, S. L., Rook, G. A. W., & Lowry, C. A. (2006) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399406000068 · Cited by 519
Sleep in elite athletes and nutritional interventions to enhance sleep
Halson, S. L. (2014) · Sports Medicine · doi:10.1007/s40279-014-0147-0 · Cited by 502
The source of cerebral insulin
Banks, W. A. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.040 · Cited by 489
Metadata
- Authors
- Fernstrom, J. D., & Wurtman, R. J.
- Venue
- Science
- Published
- 1971-07-09
- Volume
- 173
- Issue
- 3992
- Pages
- 149-152
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2068535052
- Cited by
- 1,016
- References
- 20
- FWCI
- 16.52
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan Levels. https://app.cochat.ai/papers/10.1126/science.173.3992.149
- The paper
- Fernstrom, J. D., & Wurtman, R. J. (1971). Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan Levels. Science. https://doi.org/10.1126/science.173.3992.149
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
